الية العمل

The nitrosoureas exert cytotoxic effects by an alkylation that inhibits replication
and, eventually, RNA and protein synthesis

Nitrosoureas also inhibit several key enzymatic processes by carbamoylation of amino acids in proteins in the targeted cells.

Carmustine is administered IV and as chemotherapy wafer implants, whereas
lomustine is given orally.

Mechlorethamine (nitrogen mustard)
Its ability to cause lymphocytopenia led to its use in lymphatic cancers

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مراجعة لاحد ادوية ال DMARDs

ملخص سريع DMARDs

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تجميع كل ال Contraindications



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1 MCQ lec7

2 MCQ lec 8

5 MCQ lec 10
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@DrCube_Pharmacy_Registration

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@Pharmacologyquestion_bot

Melphalan, a phenylalanine derivative of nitrogen mustard, is used in the
treatment of multiple myeloma.

The dose of melphalan is carefully adjusted by monitoring the platelet and white blood cell counts.

Other alkylating agents

Mechlorethamine (nitrogen mustard)=
Its ability to cause lymphocytopenia led to its use in lymphatic cancers


Melphalan =
a phenylalanine derivative of nitrogen mustard, is used in the
treatment of multiple myeloma.
The dose of melphalan is carefully adjusted by monitoring the platelet and white blood cell counts.


Chlorambucil =
is used in the treatment of chronic lymphocytic leukemia.


Busulfan =
is an alkylating agent that is effective against chronic myelogenous
leukemia This agent can cause pulmonary fibrosis (“busulfan lung”)

مهم

Microtubule Inhibitors

Vincristine (VX) and vinblastine (VBL) are structurally related compounds derived
from the periwinkle plant, Vinca rosea. They are, therefore, referred to as the Vinca
alkaloids.

vinorelbine (VRB) is a less neurotoxic agent

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