Lec3.
1-Steric inhibition around the ester in some cases improve the prodrug from being hydrolyzed.❎
2-Double ester prodrug of ampicillin cannot administer orally, e.g. Bacampicillin.❎
3-succinate, phosphates, sulfonates:decrease the water solubility of the agents.❎
4- phosphate ester is better than succinate because the former is more stable.✅
5-azo linkage can be broken by esterase.❎
6- clindamycin phosphate injection is better than clindamycin injection because phosphate ester are more soluble.✅
7-amide are chemically stable and there is no amidase enzyme so it is less prefer in prodrug approach.✅
8- Mannich bases result from the reaction of two amines with an aldehyde or ketone.✅
9- succinate ester are self-hydrolyze and not need esterase.✅
10- Methenamine consider as azo prodrug.❎
1-Steric inhibition around the ester in some cases improve the prodrug from being hydrolyzed.❎
2-Double ester prodrug of ampicillin cannot administer orally, e.g. Bacampicillin.❎
3-succinate, phosphates, sulfonates:decrease the water solubility of the agents.❎
4- phosphate ester is better than succinate because the former is more stable.✅
5-azo linkage can be broken by esterase.❎
6- clindamycin phosphate injection is better than clindamycin injection because phosphate ester are more soluble.✅
7-amide are chemically stable and there is no amidase enzyme so it is less prefer in prodrug approach.✅
8- Mannich bases result from the reaction of two amines with an aldehyde or ketone.✅
9- succinate ester are self-hydrolyze and not need esterase.✅
10- Methenamine consider as azo prodrug.❎
❤1
Lec3. T or F:
1-clindamycin phosphate injection is better than clindamycin injection because phosphate ester are more soluble.✅
2-amide are chemically stable and there is no amidase enzyme so it is prefer in prodrug approach.❎
3- Mannich bases result from the reaction of two amines with an ester.❎
4- phosphate ester are self-hydrolyze and not need esterase.❎
5- Methenamine consider as carbonyl prodrug.✅
6-Steric inhibition around the ester in some cases improve the prodrug from being hydrolyzed.❎
7- Double ester prodrug of ampicillin can be administered orally, e.g. Bacampicillin.✅
8-succinate, phosphates, sulfonates :increase the lipid solubility of the agents.❎
9- phosphate ester is better than succinate because the former is more stable.✅
10-azo linkage can be broken by esterase.❎
1-clindamycin phosphate injection is better than clindamycin injection because phosphate ester are more soluble.✅
2-amide are chemically stable and there is no amidase enzyme so it is prefer in prodrug approach.❎
3- Mannich bases result from the reaction of two amines with an ester.❎
4- phosphate ester are self-hydrolyze and not need esterase.❎
5- Methenamine consider as carbonyl prodrug.✅
6-Steric inhibition around the ester in some cases improve the prodrug from being hydrolyzed.❎
7- Double ester prodrug of ampicillin can be administered orally, e.g. Bacampicillin.✅
8-succinate, phosphates, sulfonates :increase the lipid solubility of the agents.❎
9- phosphate ester is better than succinate because the former is more stable.✅
10-azo linkage can be broken by esterase.❎
Lec4. T or F
1-Bioprecursor prodrugs contain a latent functional group undergo changes inside the body.✅
2-Oxidative activation is the preferred way of activation for bioprecursor prodrug.✅
3-Bioprecursor is better than carrier linked prodrug for many reasons.❎
4- sulandac undergo oxidation to give active drug.❎
5-Nabumetone undergo reduction to give 6-MNA.❎
1-Bioprecursor prodrugs contain a latent functional group undergo changes inside the body.✅
2-Oxidative activation is the preferred way of activation for bioprecursor prodrug.✅
3-Bioprecursor is better than carrier linked prodrug for many reasons.❎
4- sulandac undergo oxidation to give active drug.❎
5-Nabumetone undergo reduction to give 6-MNA.❎
Lec1.Q / give the definition of prodrug and classify?
Lec1. Q / Types of carrier linked prodrugs?
Lec1. Q / definition of Soft drugs?
Lec1. Q / prodrug types?
Lec5. Q / What is the advantage of phosphorulation for the cell?
Lec5. Q / what is the advantage of the prodrug idoxuridine?
Lec5. Q / What is /are the basic goal of chemical delivery system?
Lec1. Q / Types of carrier linked prodrugs?
Lec1. Q / definition of Soft drugs?
Lec1. Q / prodrug types?
Lec5. Q / What is the advantage of phosphorulation for the cell?
Lec5. Q / what is the advantage of the prodrug idoxuridine?
Lec5. Q / What is /are the basic goal of chemical delivery system?
❤1
Audio
#تسجيلات_عضوية_نظري
⭕️المحاضرة الاولى⭕️
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⭕️المحاضرة الاولى⭕️
PRODRUGS ، Part1
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Forwarded from تسجيلات نحو الرسوب
#تسجيلات_عضوية_نظري
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⭕️المحاضرة الثانية⭕️
PRODRUGS , Part2
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Audio
#تسجيلات_عضوية_نظري
⭕️المحاضرة الثالثة ⭕️
📚الملزمة : click here
📽️ فيديو توضيحي :
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⭕️المحاضرة الثالثة ⭕️
PRODRUGS ، Part 3
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📽️ فيديو توضيحي :
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❤1
راح ادز شرح قديم للدكتور + شرح طلاب العام (من تقرون قارنوا مع الملزمة ؛ لأن الدكتور محدث الملازم )👍🏻
🔰تسجيلات عضوية سنين سابقة 🔰
* قارنوا الشرح مع الملزمة ; لأن الدكتور كال هالسنة محدث الملزمة ( خاف أكو شيء إضافي) .
👨🏻🏫شرح الدكتور (سنين سابقة):
💠Lec1 | click here
💠Lec2 | click here
💠Lec3 | click here
💠Lec4 | click here
💠Lec5 | click here
👩🏻🏫شرح طلاب العام :
💠Lec1 | click here
💠Lec2 | click here
💠Lec3 | click here
💠Lec4 | click here
💠Lec5 | click here
* قارنوا الشرح مع الملزمة ; لأن الدكتور كال هالسنة محدث الملزمة ( خاف أكو شيء إضافي) .
👨🏻🏫شرح الدكتور (سنين سابقة):
💠Lec1 | click here
💠Lec2 | click here
💠Lec3 | click here
💠Lec4 | click here
💠Lec5 | click here
👩🏻🏫شرح طلاب العام :
💠Lec1 | click here
💠Lec2 | click here
💠Lec3 | click here
💠Lec4 | click here
💠Lec5 | click here