Lec2 T or F
1-in codrug the two drug prefer to have same pharmacokinetics. ❎
2- EMP can be given orally due to its high lipophilicity. ❎
3- Generally ester consider stable and lipophilic. ❎
4- Ester is the best bond in prodrug design. ✅
5- We can use ester to design any prodrug. ❎
6- Ester hydrolysis can be manipulated by steric and electronic factors. ✅
7- In design of epinephrine prodrug we bind the drug to a non-polar alcohol. ❎
8- One advantage of Prodrug intended to decrease solubility is to increase duration. ✅
9- Epinephrine is less stable than Dipivefrin. ✅
10- Erythromycin is a prodrug used to overcome an unpleasant taste of original drug.❎
1-in codrug the two drug prefer to have same pharmacokinetics. ❎
2- EMP can be given orally due to its high lipophilicity. ❎
3- Generally ester consider stable and lipophilic. ❎
4- Ester is the best bond in prodrug design. ✅
5- We can use ester to design any prodrug. ❎
6- Ester hydrolysis can be manipulated by steric and electronic factors. ✅
7- In design of epinephrine prodrug we bind the drug to a non-polar alcohol. ❎
8- One advantage of Prodrug intended to decrease solubility is to increase duration. ✅
9- Epinephrine is less stable than Dipivefrin. ✅
10- Erythromycin is a prodrug used to overcome an unpleasant taste of original drug.❎
❤🔥1
Lec2. T or F
1-in codrug the two drug prefer to have synergism.✅
2- EMP can be given orally due to phosphate promoiety.✅
3- Generally ester consider stable and lipophilic.❎
4- Ester is the best bond in prodrug design.✅
5- We can use ester to design any prodrug.❎
6- Ester lipophilicity can be manipulated by steric and electronic factors.❎
7- In design of epinephrine prodrug we bind the drug to a non-polar carboxylic acid.✅
8-One advantage of Prodrug intended to decrease
solubility is to increase absorption.✅
9- Epinephrine is more lipophilic than Dipivefrin.❎
10- Clindamycin phosphate is a prodrug used to overcome an unpleasant taste of original drug.❎
1-in codrug the two drug prefer to have synergism.✅
2- EMP can be given orally due to phosphate promoiety.✅
3- Generally ester consider stable and lipophilic.❎
4- Ester is the best bond in prodrug design.✅
5- We can use ester to design any prodrug.❎
6- Ester lipophilicity can be manipulated by steric and electronic factors.❎
7- In design of epinephrine prodrug we bind the drug to a non-polar carboxylic acid.✅
8-One advantage of Prodrug intended to decrease
solubility is to increase absorption.✅
9- Epinephrine is more lipophilic than Dipivefrin.❎
10- Clindamycin phosphate is a prodrug used to overcome an unpleasant taste of original drug.❎
❤1❤🔥1
Lec3.
1-Steric inhibition around the ester in some cases improve the prodrug from being hydrolyzed.❎
2-Double ester prodrug of ampicillin cannot administer orally, e.g. Bacampicillin.❎
3-succinate, phosphates, sulfonates:decrease the water solubility of the agents.❎
4- phosphate ester is better than succinate because the former is more stable.✅
5-azo linkage can be broken by esterase.❎
6- clindamycin phosphate injection is better than clindamycin injection because phosphate ester are more soluble.✅
7-amide are chemically stable and there is no amidase enzyme so it is less prefer in prodrug approach.✅
8- Mannich bases result from the reaction of two amines with an aldehyde or ketone.✅
9- succinate ester are self-hydrolyze and not need esterase.✅
10- Methenamine consider as azo prodrug.❎
1-Steric inhibition around the ester in some cases improve the prodrug from being hydrolyzed.❎
2-Double ester prodrug of ampicillin cannot administer orally, e.g. Bacampicillin.❎
3-succinate, phosphates, sulfonates:decrease the water solubility of the agents.❎
4- phosphate ester is better than succinate because the former is more stable.✅
5-azo linkage can be broken by esterase.❎
6- clindamycin phosphate injection is better than clindamycin injection because phosphate ester are more soluble.✅
7-amide are chemically stable and there is no amidase enzyme so it is less prefer in prodrug approach.✅
8- Mannich bases result from the reaction of two amines with an aldehyde or ketone.✅
9- succinate ester are self-hydrolyze and not need esterase.✅
10- Methenamine consider as azo prodrug.❎
❤1
Lec3. T or F:
1-clindamycin phosphate injection is better than clindamycin injection because phosphate ester are more soluble.✅
2-amide are chemically stable and there is no amidase enzyme so it is prefer in prodrug approach.❎
3- Mannich bases result from the reaction of two amines with an ester.❎
4- phosphate ester are self-hydrolyze and not need esterase.❎
5- Methenamine consider as carbonyl prodrug.✅
6-Steric inhibition around the ester in some cases improve the prodrug from being hydrolyzed.❎
7- Double ester prodrug of ampicillin can be administered orally, e.g. Bacampicillin.✅
8-succinate, phosphates, sulfonates :increase the lipid solubility of the agents.❎
9- phosphate ester is better than succinate because the former is more stable.✅
10-azo linkage can be broken by esterase.❎
1-clindamycin phosphate injection is better than clindamycin injection because phosphate ester are more soluble.✅
2-amide are chemically stable and there is no amidase enzyme so it is prefer in prodrug approach.❎
3- Mannich bases result from the reaction of two amines with an ester.❎
4- phosphate ester are self-hydrolyze and not need esterase.❎
5- Methenamine consider as carbonyl prodrug.✅
6-Steric inhibition around the ester in some cases improve the prodrug from being hydrolyzed.❎
7- Double ester prodrug of ampicillin can be administered orally, e.g. Bacampicillin.✅
8-succinate, phosphates, sulfonates :increase the lipid solubility of the agents.❎
9- phosphate ester is better than succinate because the former is more stable.✅
10-azo linkage can be broken by esterase.❎
Lec4. T or F
1-Bioprecursor prodrugs contain a latent functional group undergo changes inside the body.✅
2-Oxidative activation is the preferred way of activation for bioprecursor prodrug.✅
3-Bioprecursor is better than carrier linked prodrug for many reasons.❎
4- sulandac undergo oxidation to give active drug.❎
5-Nabumetone undergo reduction to give 6-MNA.❎
1-Bioprecursor prodrugs contain a latent functional group undergo changes inside the body.✅
2-Oxidative activation is the preferred way of activation for bioprecursor prodrug.✅
3-Bioprecursor is better than carrier linked prodrug for many reasons.❎
4- sulandac undergo oxidation to give active drug.❎
5-Nabumetone undergo reduction to give 6-MNA.❎
Lec1.Q / give the definition of prodrug and classify?
Lec1. Q / Types of carrier linked prodrugs?
Lec1. Q / definition of Soft drugs?
Lec1. Q / prodrug types?
Lec5. Q / What is the advantage of phosphorulation for the cell?
Lec5. Q / what is the advantage of the prodrug idoxuridine?
Lec5. Q / What is /are the basic goal of chemical delivery system?
Lec1. Q / Types of carrier linked prodrugs?
Lec1. Q / definition of Soft drugs?
Lec1. Q / prodrug types?
Lec5. Q / What is the advantage of phosphorulation for the cell?
Lec5. Q / what is the advantage of the prodrug idoxuridine?
Lec5. Q / What is /are the basic goal of chemical delivery system?
❤1
Audio
#تسجيلات_عضوية_نظري
⭕️المحاضرة الاولى⭕️
📚الملزمة: click here
🎥تسجيل المحاضرة على اليوتيوب:
Click here
⭕️المحاضرة الاولى⭕️
PRODRUGS ، Part1
📚الملزمة: click here
🎥تسجيل المحاضرة على اليوتيوب:
Click here
Forwarded from تسجيلات نحو الرسوب
#تسجيلات_عضوية_نظري
⭕️المحاضرة الثانية⭕️
📚الملزمة : click here
🎥 شرح المحاضرة على اليوتيوب :
CLICK HERE
⭕️المحاضرة الثانية⭕️
PRODRUGS , Part2
📚الملزمة : click here
🎥 شرح المحاضرة على اليوتيوب :
CLICK HERE
❤1
Audio
#تسجيلات_عضوية_نظري
⭕️المحاضرة الثالثة ⭕️
📚الملزمة : click here
📽️ فيديو توضيحي :
Click here
⭕️المحاضرة الثالثة ⭕️
PRODRUGS ، Part 3
📚الملزمة : click here
📽️ فيديو توضيحي :
Click here
Audio
❤1
راح ادز شرح قديم للدكتور + شرح طلاب العام (من تقرون قارنوا مع الملزمة ؛ لأن الدكتور محدث الملازم )👍🏻
🔰تسجيلات عضوية سنين سابقة 🔰
* قارنوا الشرح مع الملزمة ; لأن الدكتور كال هالسنة محدث الملزمة ( خاف أكو شيء إضافي) .
👨🏻🏫شرح الدكتور (سنين سابقة):
💠Lec1 | click here
💠Lec2 | click here
💠Lec3 | click here
💠Lec4 | click here
💠Lec5 | click here
👩🏻🏫شرح طلاب العام :
💠Lec1 | click here
💠Lec2 | click here
💠Lec3 | click here
💠Lec4 | click here
💠Lec5 | click here
* قارنوا الشرح مع الملزمة ; لأن الدكتور كال هالسنة محدث الملزمة ( خاف أكو شيء إضافي) .
👨🏻🏫شرح الدكتور (سنين سابقة):
💠Lec1 | click here
💠Lec2 | click here
💠Lec3 | click here
💠Lec4 | click here
💠Lec5 | click here
👩🏻🏫شرح طلاب العام :
💠Lec1 | click here
💠Lec2 | click here
💠Lec3 | click here
💠Lec4 | click here
💠Lec5 | click here