....... is sometimes included as an alkylating agent but is included here because it
is a naturally occurring material.
is a naturally occurring material.
Anonymous Quiz
50%
Mitomycin
32%
Bleomycin
10%
Tamoxifen
8%
Flutamide
Microtubules are part of cytoskeleton involved in
Anonymous Quiz
5%
cell movement
2%
cell to cell signalling
19%
movement of chromosomes during mitosis
75%
All of the above
Vincristine and vinblastine differ only in the group attached to the dihydroindole nitrogen
Anonymous Quiz
72%
T
28%
F
✨طريقك نحو الرسوب✨
Vincristine and vinblastine differ only in the group attached to the dihydroindole nitrogen
⚠️Vincristine and vinblastine differ only in the group attached to the
dihydroindole nitrogen, which is a methyl group in vinblastine and a formyl group in vincristine.
dihydroindole nitrogen, which is a methyl group in vinblastine and a formyl group in vincristine.
Flutamide Is an antagonist of the estrogen receptor in breast tissue via its active metabolite
Anonymous Quiz
46%
T
54%
F
Flutamide is an Iv, non-steroidal
antiandrogen drug primarily used to treat prostate cancer
antiandrogen drug primarily used to treat prostate cancer
Anonymous Quiz
58%
T
42%
F
What are the major side effects associated with Methotrexate use? B) Liver toxicity and kidney failure
Anonymous Quiz
2%
Neurological disorders
11%
Hair loss and skin rash
82%
Bone marrow suppression and pulmonary
5%
Hypertension and diabetes
What is the purpose of dosing uracil along with 5-FU or 5-FU prodrugs?
Anonymous Quiz
8%
Less activity than cisplatin
80%
Saturate dihydropyrimidine dehydrogenase (DPD)
11%
Inhibit thymidylate synthase
1%
Saturate dihydrofolate reductase
Select the incorrect statement regarding the carboplatin
Anonymous Quiz
9%
It is an organometallic antineoplastic compound
24%
Less activity than cisplatin
14%
Can given IV
15%
The leaving group was incorporated into a chelate.
37%
Non of the above
Many of the antineoplastic antibiotics are produced by the soil fungus Streptomyces
Anonymous Quiz
81%
true
19%
false
Both the antibiotic and natural product classes have multiple _____ effects on cell growth.
Anonymous Quiz
89%
inhibitory
11%
stimulitory
There are several mechanisms by which
these agents target DNA, including
these agents target DNA, including
Anonymous Quiz
6%
alkylation,l
5%
intercalation
2%
strand breakage
87%
all of the above
The actinomycins are a group of compounds contain the same phenoxazone chromophore
Anonymous Quiz
72%
true
28%
false
The carbamate derivative of 5-FU is called
Anonymous Quiz
59%
Capecitabine
7%
Gemcitabine
5%
Decitabine
30%
Tegafur
The type of cancer that originate and start in the connective tissue is called sarcoma
Anonymous Quiz
83%
T
17%
F
Which of the following is a potential side effect of alkylating agents?
Anonymous Quiz
7%
Enhanced repair enzyme activity
29%
Inhibition of DNA synthesis
18%
Exclusively mutagenic effects
45%
Reactivity with other biomolecules
The anthracycline antibiotics are characterized by ______ anthracene nucleus
Anonymous Quiz
14%
planar nonoxidized
8%
spherical oxidized
72%
planar oxidized
6%
spherical nonoxidized
what is the mechanism of
anthracycline?
..by exhibit their cytotoxic effects initially focused on the ability of the compounds to associate with DNA resulting from intercalation of their planar ring system reinforced by auxiliary binding of the amino sugar.
anthracycline?
..by exhibit their cytotoxic effects initially focused on the ability of the compounds to associate with DNA resulting from intercalation of their planar ring system reinforced by auxiliary binding of the amino sugar.
Several anthracyclines are used clinically such as
Anonymous Quiz
25%
inhibitor of microtubule function
62%
doxorubicin ,daunorubicin
13%
oxidized anthracene nucleus
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