41. What is the primary classification of sulfonylureas based on their mechanism of action?
Anonymous Quiz
4%
a. Insulin sensitizers
80%
b. Insulin secretagogues
9%
c. Glucagon inhibitors
6%
d. Lipid-lowering agents
2%
e. Beta-blockers
42. Which of the following is NOT a second-generation sulfonylurea used in clinical practice?
Anonymous Quiz
3%
a. Glyburide
11%
b. Glipizide
4%
c. Glimepiride
75%
d. Metformin
8%
e. All of the above are second-generation sulfonylureas
43. What is the primary mechanism of action of sulfonylureas?
Anonymous Quiz
5%
a. Inhibition of insulin release
31%
b. Activation of ATP-sensitive K+ channels
3%
c. Blockade of Ca2+ influx
56%
d. Stimulation of insulin release from β cells
5%
e. Inhibition of hepatic glucose production
44. How do sulfonylureas affect ATP-sensitive K+ channels in pancreatic β cells?
Anonymous Quiz
9%
a. Activation
15%
b. Inhibition
70%
c. Blockade
4%
d. Sensitization
3%
e. None of the above
45. What is the result of blocking ATP-sensitive K+ channels in pancreatic β cells by sulfonylureas?
Anonymous Quiz
5%
a. Hyperglycemia
11%
b. Insulin sensitization
76%
c. Depolarization
7%
d. Increased hepatic glucose production
1%
e. Glucagon release
46. Besides promoting insulin release, what additional effects may sulfonylureas have?
Anonymous Quiz
23%
a. Increased hepatic glucose production
22%
b. Decreased peripheral insulin sensitivity
5%
c. Inhibition of insulin synthesis
9%
d. Reduction of serum protein binding
42%
e. None of the above
🆒1
47. How are sulfonylureas primarily metabolized in the body?
Anonymous Quiz
26%
a. Renal excretion
64%
b. Hepatic metabolism
6%
c. Pulmonary clearance
3%
d. Gastrointestinal absorption
1%
e. Direct excretion through the skin
48. What is the typical duration of action for sulfonylureas?
Anonymous Quiz
7%
a. 6 to 12 hours
83%
b. 12 to 24 hours
6%
c. 24 to 36 hours
1%
d. 36 to 48 hours
4%
e. Varies depending on the patient's age
49. Which adverse effect is associated with sulfonylureas and is characterized by abnormally low blood glucose levels?
Anonymous Quiz
3%
a. Hyperglycemia
18%
b. Hyperinsulinemia
73%
c. Hypoglycemia
4%
d. Hyperlipidemia
2%
e. Hyperkalemia
50. What precaution should be taken when using sulfonylureas in patients with hepatic or renal insufficiency?
Anonymous Quiz
2%
a. Use higher doses
8%
b. Use in combination with insulin
6%
c. Monitor for hyperglycemia
82%
d. Use with caution, as accumulation may cause hypoglycemia
2%
e. Administer with anticoagulants
51. Which sulfonylurea is considered safer in renal dysfunction and in elderly patients?
Anonymous Quiz
11%
a. Glyburide
55%
b. Glipizide
19%
c. Glimepiride
9%
d. Metformin
6%
e. All have similar safety profiles
✨طريقك نحو الرسوب✨
51. Which sulfonylurea is considered safer in renal dysfunction and in elderly patients?
⚠️هنا حسب الملزمة Glipizide or glimepiride
*الدكتور حالها B
*الدكتور حالها B
😁1
52. What is the duration of action range for sulfonylureas?
Anonymous Quiz
4%
a. 6 to 12 hours
90%
b. 12 to 24 hours
6%
c. 24 to 36 hours
0%
d. 36 to 48 hours
0%
e. Varies depending on the patient's age
53. Which of the following is NOT an adverse effect of sulfonylureas?
Anonymous Quiz
11%
a. Hypoglycemia
11%
b. Hyperinsulinemia
10%
c. Weight gain
42%
d. Hyperlipidemia
27%
e. Allergic reactions
54. What risk is associated specifically with glyburide in the context of renal impairment?
Anonymous Quiz
8%
a. Increased risk of hyperglycemia
67%
b. Increased risk of hypoglycemia
7%
c. Increased risk of allergic reactions
9%
d. Increased risk of hyperinsulinemia
8%
e. No specific risks related to renal impairment
55. Which of the following conditions should be used with caution when prescribing sulfonylureas?
Anonymous Quiz
36%
a. Hepatic insufficiency
55%
b. Renal insufficiency
5%
c. Cardiovascular disease
3%
d. Respiratory conditions
1%
e. Gastrointestinal disorders
56.How do sulfonylureas differ from metformin in terms of their mechanism of action?
Anonymous Quiz
15%
a. Sulfonylureas inhibit hepatic glucose production, while metformin stimulates insulin release.
59%
b. Sulfonylureas promote insulin release, while metformin inhibits hepatic glucose production.
16%
c. Both sulfonylureas and metformin inhibit hepatic glucose production.
8%
d. Both sulfonylureas and metformin promote insulin release.
3%
e. Sulfonylureas have no effect on glucose metabolism.
57. What effect do sulfonylureas have on ATP-sensitive K+ channels in pancreatic β cells?
Anonymous Quiz
3%
a. Activation
7%
b. Inhibition
86%
c. Blockade
2%
d. Sensitization
2%
e. None of the above