33. How is NPH insulin usually given?
Anonymous Quiz
8%
a. Orally
4%
b. Intramuscularly
15%
c. Intravenously (IV)
72%
d. Subcutaneously
2%
e. Inhaled
34. What is the isoelectric point of insulin glargine responsible for?
Anonymous Quiz
4%
a. Rapid absorption
55%
b. Formation of a precipitate at the injection site
20%
c. Prolonged hypoglycemic effect with no peak
17%
d. Slow release over an extended period
4%
e. Enhanced association to albumin
35. Which long-acting insulin has the longest half-life?
Anonymous Quiz
10%
a. Insulin glargine
5%
b. Insulin detemir
68%
c. Insulin degludec
13%
d. Neutral protamine Hagedorn (NPH) insulin
5%
e. Insulin lispro
36. Why should long-acting insulins not be mixed in the same syringe with other insulins
Anonymous Quiz
61%
a. It alters the pharmacodynamic profile
6%
b. It enhances insulin sensitivity
18%
c. It reduces the risk of hypoglycemia
12%
d. It increases the overall effectiveness
3%
e. It improves patient compliance
37. What is the goal of insulin therapy in type 1 diabetes?
Anonymous Quiz
13%
a.Inducing ketosis
75%
b. Avoiding wide fluctuations in glucose
5%
c. Promoting hyperglycemia
5%
d. Increasing insulin resistance
2%
e. Enhancing lipolysis
38. What insulin analogs are classified as rapid-acting insulins?
Anonymous Quiz
5%
a. Insulin glargine and insulin detemir
8%
b. Regular insulin and insulin isophane
81%
c. Insulin lispro, insulin aspart, and insulin glulisine
2%
d. Neutral protamine Hagedorn (NPH) insulin
4%
e. Insulin degludec
41. What is the primary classification of sulfonylureas based on their mechanism of action?
Anonymous Quiz
4%
a. Insulin sensitizers
80%
b. Insulin secretagogues
9%
c. Glucagon inhibitors
6%
d. Lipid-lowering agents
2%
e. Beta-blockers
42. Which of the following is NOT a second-generation sulfonylurea used in clinical practice?
Anonymous Quiz
3%
a. Glyburide
11%
b. Glipizide
4%
c. Glimepiride
75%
d. Metformin
8%
e. All of the above are second-generation sulfonylureas
43. What is the primary mechanism of action of sulfonylureas?
Anonymous Quiz
5%
a. Inhibition of insulin release
31%
b. Activation of ATP-sensitive K+ channels
3%
c. Blockade of Ca2+ influx
56%
d. Stimulation of insulin release from β cells
5%
e. Inhibition of hepatic glucose production
44. How do sulfonylureas affect ATP-sensitive K+ channels in pancreatic β cells?
Anonymous Quiz
9%
a. Activation
15%
b. Inhibition
70%
c. Blockade
4%
d. Sensitization
3%
e. None of the above
45. What is the result of blocking ATP-sensitive K+ channels in pancreatic β cells by sulfonylureas?
Anonymous Quiz
5%
a. Hyperglycemia
11%
b. Insulin sensitization
76%
c. Depolarization
7%
d. Increased hepatic glucose production
1%
e. Glucagon release
46. Besides promoting insulin release, what additional effects may sulfonylureas have?
Anonymous Quiz
23%
a. Increased hepatic glucose production
22%
b. Decreased peripheral insulin sensitivity
5%
c. Inhibition of insulin synthesis
9%
d. Reduction of serum protein binding
42%
e. None of the above
🆒1
47. How are sulfonylureas primarily metabolized in the body?
Anonymous Quiz
26%
a. Renal excretion
64%
b. Hepatic metabolism
6%
c. Pulmonary clearance
3%
d. Gastrointestinal absorption
1%
e. Direct excretion through the skin
48. What is the typical duration of action for sulfonylureas?
Anonymous Quiz
7%
a. 6 to 12 hours
83%
b. 12 to 24 hours
6%
c. 24 to 36 hours
1%
d. 36 to 48 hours
4%
e. Varies depending on the patient's age
49. Which adverse effect is associated with sulfonylureas and is characterized by abnormally low blood glucose levels?
Anonymous Quiz
3%
a. Hyperglycemia
18%
b. Hyperinsulinemia
73%
c. Hypoglycemia
4%
d. Hyperlipidemia
2%
e. Hyperkalemia
50. What precaution should be taken when using sulfonylureas in patients with hepatic or renal insufficiency?
Anonymous Quiz
2%
a. Use higher doses
8%
b. Use in combination with insulin
6%
c. Monitor for hyperglycemia
82%
d. Use with caution, as accumulation may cause hypoglycemia
2%
e. Administer with anticoagulants
51. Which sulfonylurea is considered safer in renal dysfunction and in elderly patients?
Anonymous Quiz
11%
a. Glyburide
55%
b. Glipizide
19%
c. Glimepiride
9%
d. Metformin
6%
e. All have similar safety profiles