25. What are first-line urate-lowering agents used in chronic gout?
Anonymous Quiz
2%
a. NSAIDs
4%
b. Corticosteroids
8%
c. Uricosuric agents
80%
d. Xanthine oxidase inhibitors
6%
e. Colchicine
26. What might occur when initiating urate-lowering therapy in gout?
Anonymous Quiz
25%
a. Decreased uric acid synthesis
17%
b. Resolution of acute gout attacks
43%
c. Increased serum urate concentrations
11%
d. Rapid improvements in chronic gout symptoms
5%
e. Reduction in inflammation
27. Why should hemoglobin concentrations be monitored during tofacitinib therapy?
Anonymous Quiz
2%
a. To assess renal function
13%
b. Risk of opportunistic infections
77%
c. Potential for anemia
8%
d. Evaluation of liver enzymes
0%
e. Detection of allergic reactions
28. In addition to monitoring hemoglobin levels, what else should be checked before initiating tofacitinib therapy?
Anonymous Quiz
3%
a. Blood pressure
7%
b. Serum electrolytes
78%
c. Lymphocyte and neutrophil counts
11%
d. Liver function tests
1%
e. ECG findings
30. How do IL-1 and TNF-α contribute to the pathogenesis of rheumatoid arthritis (RA)?
Anonymous Quiz
23%
a. Suppressing synovial cell proliferation
16%
b. Inhibiting collagenase synthesis
13%
c. Enhancing proteoglycan synthesis
45%
d. Stimulating bone resorption
3%
e. Reducing inflammatory response
31. What is the primary goal of TNF-α inhibitors in RA treatment?
Anonymous Quiz
46%
a. Inducing remission
6%
b. Increasing lymphocyte counts
11%
c. Enhancing proteoglycan synthesis
11%
d. Promoting bone formation
26%
e. Reducing signs and symptoms
34. Why is infliximab not indicated for monotherapy in RA?
Anonymous Quiz
6%
a. Rapid onset of action
16%
b. Infusion-related reactions
3%
c. Increased lymphocyte counts
6%
d. Enhanced proteoglycan synthesis
70%
e. Development of anti-infliximab antibodies
35. How does abatacept modulate the inflammatory response in RA?
Anonymous Quiz
21%
a. Enhancing T cell activation
9%
b. Promoting B-cell depletion
18%
c. Blocking TNF-α interaction
9%
d. Inhibiting IL-6 receptors
43%
e. Competing with CD28 for binding
36. Which antibody is directed against the CD20 antigen on B lymphocytes?
Anonymous Quiz
8%
a. Adalimumab
6%
b. Certolizumab
73%
c. Rituximab
9%
d. Tocilizumab
4%
e. Sarilumab
❤1
38. Which enzyme do Janus kinases modulate in response to inflammatory mediators?
Anonymous Quiz
35%
a. COX-2
25%
b. Xanthine oxidase
8%
c. Aldolase
13%
d. CD20
20%
e. Hemoglobin