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18. What is administered prior to rituximab infusion to reduce reactions?
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19. What is the primary target of tocilizumab and sarilumab?
Anonymous Quiz
6%
a. TNF-α
8%
b. IL-1
78%
c. IL-6 receptors
6%
d. CD20 antigen
3%
e. CD28 protein
21. What is the primary target of tofacitinib in the treatment of RA?
Anonymous Quiz
1%
a. Interferon-alpha
12%
b. Tumor necrosis factor (TNF)
17%
c. Interleukin-6 (IL-6)
68%
d. Janus kinases
1%
e. CD20 antigen
22. When is tofacitinib typically reserved for RA treatment?
Anonymous Quiz
7%
a. First-line therapy
63%
b. Intolerance to other agents
16%
c. Only in severe RA cases
7%
d. Long-term prevention
7%
e. As monotherapy
23. What is the primary goal of therapeutic strategies for gout?
Anonymous Quiz
2%
a. Increase uric acid synthesis
18%
b. Reduce uric acid excretion
25%
c. Maintain uric acid levels above 6 mg/dL
54%
d. Lower uric acid levels below 6 mg/dL
0%
e. Enhance urate crystal formation
25. What are first-line urate-lowering agents used in chronic gout?
Anonymous Quiz
2%
a. NSAIDs
4%
b. Corticosteroids
8%
c. Uricosuric agents
80%
d. Xanthine oxidase inhibitors
6%
e. Colchicine
26. What might occur when initiating urate-lowering therapy in gout?
Anonymous Quiz
25%
a. Decreased uric acid synthesis
17%
b. Resolution of acute gout attacks
43%
c. Increased serum urate concentrations
11%
d. Rapid improvements in chronic gout symptoms
5%
e. Reduction in inflammation
27. Why should hemoglobin concentrations be monitored during tofacitinib therapy?
Anonymous Quiz
2%
a. To assess renal function
13%
b. Risk of opportunistic infections
77%
c. Potential for anemia
8%
d. Evaluation of liver enzymes
0%
e. Detection of allergic reactions
28. In addition to monitoring hemoglobin levels, what else should be checked before initiating tofacitinib therapy?
Anonymous Quiz
3%
a. Blood pressure
7%
b. Serum electrolytes
78%
c. Lymphocyte and neutrophil counts
11%
d. Liver function tests
1%
e. ECG findings
30. How do IL-1 and TNF-α contribute to the pathogenesis of rheumatoid arthritis (RA)?
Anonymous Quiz
23%
a. Suppressing synovial cell proliferation
16%
b. Inhibiting collagenase synthesis
13%
c. Enhancing proteoglycan synthesis
45%
d. Stimulating bone resorption
3%
e. Reducing inflammatory response
31. What is the primary goal of TNF-α inhibitors in RA treatment?
Anonymous Quiz
46%
a. Inducing remission
6%
b. Increasing lymphocyte counts
11%
c. Enhancing proteoglycan synthesis
11%
d. Promoting bone formation
26%
e. Reducing signs and symptoms