45. What are the actions of NSAIDs?
Anonymous Quiz
3%
a) Anti-inflammatory, antipyretic, and antiviral
5%
b) Antibiotic, analgesic, and antifungal
89%
c) Anti-inflammatory, analgesic, and antipyretic
2%
d) Anticoagulant, antihypertensive, and antispasmodic
1%
e) Antioxidant, antiseptic, and anticonvulsant
❤1
46. Which NSAID is often used at lower doses to prevent cardiovascular events?
Anonymous Quiz
1%
a) Ibuprofen
11%
b) Naproxen
80%
c) Aspirin
5%
d) Ketorolac
2%
e) Diclofenac
47. What is the mechanism of action of aspirin?
Anonymous Quiz
6%
a) Reversible inhibition of cyclooxygenase
87%
b) Irreversible inhibition of cyclooxygenase
4%
c) Activation of cyclooxygenase-1
2%
d) Stimulation of leukotriene synthesis
1%
e) Suppression of prostacyclin production
👍1
48. How do NSAIDs affect renal blood flow?
Anonymous Quiz
13%
a) Increase by promoting vasodilation
62%
b) Decrease by inhibiting prostaglandin synthesis
6%
c) Remain unchanged
11%
d) Induce acute kidney injury
9%
e) Enhance glomerular filtration
⏳MCQs Pharma Lec3 ⏳
•Biologic Disease-Modifying Antirheumatic Drugs.
⚠️اسئلة الكوز⚠️
•Biologic Disease-Modifying Antirheumatic Drugs.
⚠️اسئلة الكوز⚠️
1. What is the primary role of IL-1 and TNF-α in the pathogenesis of RA?
Anonymous Quiz
19%
a. Inhibiting proteoglycan synthesis
14%
b. Stimulating bone formation
22%
c. Suppressing synovial cell proliferation
9%
d. Reducing collagenase production
37%
e. Degrading cartilage
2. Which of the following is a non-TNF biologic agent used in RA?
Anonymous Quiz
6%
a. Adalimumab
5%
b. Certolizumab
6%
c. Golimumab
6%
d. Infliximab
77%
e. Abatacept
3. When can clinical response to TNF-α inhibitors be observed in RA patients?
Anonymous Quiz
8%
a. Within 24 hours
10%
b. Within 1 week
66%
c. Within 2 weeks
6%
d. Within 1 month
9%
e. After 3 months
4. What caution should be taken when using TNF-α inhibitors in patients with heart failure?
Anonymous Quiz
5%
a. No caution needed
28%
b. Decrease in dosage
52%
c. Avoidance due to toxicity
3%
d. Increase in dosage
12%
e. Preferential use in heart failure
💔4
5. What risk is associated with the use of TNF-α inhibitors and non-TNF biologic agents together?
Anonymous Quiz
9%
a. Joint damage improvement
20%
b. Increased risk of lymphoma
2%
c. Enhanced clinical response
67%
d. Severe infections
3%
e. Reduced side effects
💔3
6. How does adalimumab interfere with TNF-α activity?
Anonymous Quiz
3%
a. Enhances its binding to receptors
89%
b. Blocks its interaction with cell surface receptors
5%
c. Promotes its synthesis
2%
d. Increases TNF-α production
1%
e. Induces TNF-α degradation
7. What is the administration frequency of adalimumab?
Anonymous Quiz
7%
a. Daily
7%
b. Every other day
81%
c. Weekly
5%
d. Monthly
0%
e. Annually
8. What distinguishes certolizumab from other TNF-α inhibitors?
Anonymous Quiz
3%
a. Increased injection frequency
14%
b. Lower risk of infections
77%
c. Combined with pegylated substance
4%
d. Oral administration
2%
e. No adverse effects
9. How often is certolizumab administered?
Anonymous Quiz
9%
a. Weekly
8%
b. Monthly
77%
c. Every 2 weeks
5%
d. Every 3 months
1%
e. Twice daily
10. What is the mechanism of action of etanercept?
Anonymous Quiz
4%
a. Enhances TNF-α synthesis
82%
b. Blocks TNF-α receptors
6%
c. Induces TNF-α degradation
4%
d. Promotes TNF-α release
4%
e. Stimulates TNF-α production
11. How does golimumab neutralize TNF-α activity?
Anonymous Quiz
4%
a. Inducing TNF-α production
4%
b. Enhancing TNF-α receptors
81%
c. Blocking interaction with cell surface receptors
1%
d. Stimulating TNF-α release
10%
e. Binding to CD80/CD86 protein
12. What is the administration frequency of golimumab?
Anonymous Quiz
9%
a. Every 2 weeks
67%
b. Once a month
6%
c. Twice daily
8%
d. Every 8 weeks
9%
e. Every 4 weeks
13. What is the composition of infliximab, a chimeric monoclonal antibody?
Anonymous Quiz
3%
a. Fully human
11%
b. Murine
82%
c. Human and murine regions
1%
d. Rat-derived
2%
e. Synthetic
14. Why is infliximab not indicated for monotherapy in RA?
Anonymous Quiz
4%
a. Increased efficacy
2%
b. Reduced infusion reactions
81%
c. Development of anti-infliximab antibodies
8%
d. Improved B-cell depletion
4%
e. Prevention of TNF-α binding
15. How does abatacept modulate T cell activation?
Anonymous Quiz
4%
a. Enhances CD28 binding
10%
b. Stimulates CD80/CD86 production
85%
c. Competes with CD28 for binding on CD80/CD86 protein
1%
d. Induces B-cell depletion
0%
e. Increases TNF-α release