37. Why are glucocorticoids commonly used in patients with rheumatoid arthritis?
Anonymous Quiz
5%
a. Disease modification
64%
b. Provide symptomatic relief
19%
c. Induce remission
9%
d. Slow structural damage
2%
e. Enhance joint mobility
38. What is the primary consideration when using glucocorticoids in RA?
Anonymous Quiz
11%
a. Long-term use
5%
b. High dosage
58%
c. Shortest duration possible
20%
d. Combination with other DMARDs
5%
e. Use in pregnancy
39. What is the unknown mechanism of action for hydroxychloroquine in autoimmune disorders?
Anonymous Quiz
4%
a. COX-2 inhibition
21%
b. Cytokine suppression
60%
c. Unclear
8%
d. DHODH activation
7%
e. Pyrimidine synthesis enhancement
40. Why should glucocorticoids be used cautiously in RA?
Anonymous Quiz
9%
a. Rapid onset of action
74%
b. Long-term use can cause adverse effects
11%
c. Low efficacy in relieving symptoms
3%
d. Preferred as monotherapy
2%
e. Minimal impact on structural damage
41. What is the primary function of inflammation in the body?
Anonymous Quiz
10%
a) Destroying red blood cells
61%
b) Promoting tissue repair
9%
c) Inactivating digestive enzymes
18%
d) Initiating fever response
2%
e) Enhancing nutrient absorption
42. In rheumatoid arthritis (RA), which cells initiate an inflammatory attack?
Anonymous Quiz
5%
a) Neutrophils
84%
b) T lymphocytes
7%
c) Macrophages
5%
d) B lymphocytes
0%
e) Eosinophils
43. Which enzyme is responsible for the physiologic production of prostanoids?
Anonymous Quiz
68%
a) Cyclooxygenase-1 (COX-1)
10%
b) Cyclooxygenase-2 (COX-2)
7%
c) Lipoxygenase
4%
d) Rheumatoid factor synthase
12%
e) Prostacyclinase
44. What is the main goal of pharmacotherapy for rheumatoid arthritis (RA)?
Anonymous Quiz
3%
a) Inducing inflammation
90%
b) Slowing disease progression and reducing inflammation
3%
c) Promoting joint destruction
4%
d) Enhancing immune system activation
0%
e) Stimulating cytokine release
45. What are the actions of NSAIDs?
Anonymous Quiz
3%
a) Anti-inflammatory, antipyretic, and antiviral
5%
b) Antibiotic, analgesic, and antifungal
89%
c) Anti-inflammatory, analgesic, and antipyretic
2%
d) Anticoagulant, antihypertensive, and antispasmodic
1%
e) Antioxidant, antiseptic, and anticonvulsant
❤1
46. Which NSAID is often used at lower doses to prevent cardiovascular events?
Anonymous Quiz
1%
a) Ibuprofen
11%
b) Naproxen
80%
c) Aspirin
5%
d) Ketorolac
2%
e) Diclofenac
47. What is the mechanism of action of aspirin?
Anonymous Quiz
6%
a) Reversible inhibition of cyclooxygenase
87%
b) Irreversible inhibition of cyclooxygenase
4%
c) Activation of cyclooxygenase-1
2%
d) Stimulation of leukotriene synthesis
1%
e) Suppression of prostacyclin production
👍1
48. How do NSAIDs affect renal blood flow?
Anonymous Quiz
13%
a) Increase by promoting vasodilation
62%
b) Decrease by inhibiting prostaglandin synthesis
6%
c) Remain unchanged
11%
d) Induce acute kidney injury
9%
e) Enhance glomerular filtration
⏳MCQs Pharma Lec3 ⏳
•Biologic Disease-Modifying Antirheumatic Drugs.
⚠️اسئلة الكوز⚠️
•Biologic Disease-Modifying Antirheumatic Drugs.
⚠️اسئلة الكوز⚠️
1. What is the primary role of IL-1 and TNF-α in the pathogenesis of RA?
Anonymous Quiz
19%
a. Inhibiting proteoglycan synthesis
14%
b. Stimulating bone formation
22%
c. Suppressing synovial cell proliferation
9%
d. Reducing collagenase production
37%
e. Degrading cartilage
2. Which of the following is a non-TNF biologic agent used in RA?
Anonymous Quiz
6%
a. Adalimumab
5%
b. Certolizumab
6%
c. Golimumab
6%
d. Infliximab
77%
e. Abatacept
3. When can clinical response to TNF-α inhibitors be observed in RA patients?
Anonymous Quiz
8%
a. Within 24 hours
10%
b. Within 1 week
66%
c. Within 2 weeks
6%
d. Within 1 month
9%
e. After 3 months
4. What caution should be taken when using TNF-α inhibitors in patients with heart failure?
Anonymous Quiz
5%
a. No caution needed
28%
b. Decrease in dosage
52%
c. Avoidance due to toxicity
3%
d. Increase in dosage
12%
e. Preferential use in heart failure
💔4
5. What risk is associated with the use of TNF-α inhibitors and non-TNF biologic agents together?
Anonymous Quiz
9%
a. Joint damage improvement
20%
b. Increased risk of lymphoma
2%
c. Enhanced clinical response
67%
d. Severe infections
3%
e. Reduced side effects
💔3
6. How does adalimumab interfere with TNF-α activity?
Anonymous Quiz
3%
a. Enhances its binding to receptors
89%
b. Blocks its interaction with cell surface receptors
5%
c. Promotes its synthesis
2%
d. Increases TNF-α production
1%
e. Induces TNF-α degradation
7. What is the administration frequency of adalimumab?
Anonymous Quiz
7%
a. Daily
7%
b. Every other day
81%
c. Weekly
5%
d. Monthly
0%
e. Annually