28. What is the mainstay of treatment in patients with rheumatoid or psoriatic arthritis?
Anonymous Quiz
4%
a. Celecoxib
8%
b. NSAIDs
71%
c. Methotrexate
12%
d. Hydroxychloroquine
5%
e. Sulfasalazine
❤1
29. How does leucovorin supplementation impact the adverse effects of methotrexate?
Anonymous Quiz
11%
a. Increases severity
6%
b. Has no effect
61%
c. Reduces severity
15%
d. Enhances gastrointestinal effects
7%
e. Improves liver function
30. What is a contraindication for the use of methotrexate?
Anonymous Quiz
7%
a. Renal impairment
81%
b. Pregnancy
7%
c. Cardiovascular diseases
4%
d. Respiratory disorders
1%
e. Diabetes
31. What is the primary use of hydroxychloroquine in rheumatoid arthritis (RA)?
Anonymous Quiz
3%
a. Late-stage RA
20%
b. Moderate to severe RA
68%
c. Early, mild RA
6%
d. Psoriatic arthritis
2%
e. Osteoarthritis
32. What is the potential risk associated with hydroxychloroquine use?
Anonymous Quiz
7%
a. Renal damage
80%
b. Ocular toxicity
5%
c. Cardiovascular events
4%
d. Respiratory disturbances
5%
e. Gastrointestinal bleeding
33. How does leflunomide exert its action in rheumatoid arthritis?
Anonymous Quiz
4%
a. Inhibition of COX-2
17%
b. Suppression of cytokine production
18%
c. Activation of dihydroorotate dehydrogenase
3%
d. Enhancement of pyrimidine synthesis
58%
e. Inhibition of DHODH
34. In which patients is leflunomide contraindicated?
Anonymous Quiz
3%
a. Those with gastrointestinal disorders
11%
b. Individuals with cardiovascular diseases
76%
c. Pregnant women
3%
d. Patients with respiratory disorders
7%
e. Those with renal impairment
35. How does sulfasalazine compare to leflunomide in terms of onset of activity?
Anonymous Quiz
13%
a. Faster onset
50%
b. Slower onset
29%
c. Similar onset
4%
d. Immediate onset
3%
e. Delayed onset
🤔5
36. What are common adverse effects associated with sulfasalazine use?
Anonymous Quiz
8%
a. Ocular toxicity
10%
b. CNS disturbances
10%
c. Weight loss
63%
d. Nausea, vomiting, anorexia
9%
e. Hypokalemia
37. Why are glucocorticoids commonly used in patients with rheumatoid arthritis?
Anonymous Quiz
5%
a. Disease modification
64%
b. Provide symptomatic relief
19%
c. Induce remission
9%
d. Slow structural damage
2%
e. Enhance joint mobility
38. What is the primary consideration when using glucocorticoids in RA?
Anonymous Quiz
11%
a. Long-term use
5%
b. High dosage
58%
c. Shortest duration possible
20%
d. Combination with other DMARDs
5%
e. Use in pregnancy
39. What is the unknown mechanism of action for hydroxychloroquine in autoimmune disorders?
Anonymous Quiz
4%
a. COX-2 inhibition
21%
b. Cytokine suppression
60%
c. Unclear
8%
d. DHODH activation
7%
e. Pyrimidine synthesis enhancement
40. Why should glucocorticoids be used cautiously in RA?
Anonymous Quiz
9%
a. Rapid onset of action
74%
b. Long-term use can cause adverse effects
11%
c. Low efficacy in relieving symptoms
3%
d. Preferred as monotherapy
2%
e. Minimal impact on structural damage
41. What is the primary function of inflammation in the body?
Anonymous Quiz
10%
a) Destroying red blood cells
61%
b) Promoting tissue repair
9%
c) Inactivating digestive enzymes
18%
d) Initiating fever response
2%
e) Enhancing nutrient absorption
42. In rheumatoid arthritis (RA), which cells initiate an inflammatory attack?
Anonymous Quiz
5%
a) Neutrophils
84%
b) T lymphocytes
7%
c) Macrophages
5%
d) B lymphocytes
0%
e) Eosinophils
43. Which enzyme is responsible for the physiologic production of prostanoids?
Anonymous Quiz
68%
a) Cyclooxygenase-1 (COX-1)
10%
b) Cyclooxygenase-2 (COX-2)
7%
c) Lipoxygenase
4%
d) Rheumatoid factor synthase
12%
e) Prostacyclinase
44. What is the main goal of pharmacotherapy for rheumatoid arthritis (RA)?
Anonymous Quiz
3%
a) Inducing inflammation
90%
b) Slowing disease progression and reducing inflammation
3%
c) Promoting joint destruction
4%
d) Enhancing immune system activation
0%
e) Stimulating cytokine release
45. What are the actions of NSAIDs?
Anonymous Quiz
3%
a) Anti-inflammatory, antipyretic, and antiviral
5%
b) Antibiotic, analgesic, and antifungal
89%
c) Anti-inflammatory, analgesic, and antipyretic
2%
d) Anticoagulant, antihypertensive, and antispasmodic
1%
e) Antioxidant, antiseptic, and anticonvulsant
❤1
46. Which NSAID is often used at lower doses to prevent cardiovascular events?
Anonymous Quiz
1%
a) Ibuprofen
11%
b) Naproxen
80%
c) Aspirin
5%
d) Ketorolac
2%
e) Diclofenac
47. What is the mechanism of action of aspirin?
Anonymous Quiz
6%
a) Reversible inhibition of cyclooxygenase
87%
b) Irreversible inhibition of cyclooxygenase
4%
c) Activation of cyclooxygenase-1
2%
d) Stimulation of leukotriene synthesis
1%
e) Suppression of prostacyclin production
👍1
48. How do NSAIDs affect renal blood flow?
Anonymous Quiz
13%
a) Increase by promoting vasodilation
62%
b) Decrease by inhibiting prostaglandin synthesis
6%
c) Remain unchanged
11%
d) Induce acute kidney injury
9%
e) Enhance glomerular filtration