⭕️11. Which of the following antidepressants is a selective short-acting MAO-A inhibitor?
Anonymous Quiz
15%
a) Maprotiline
18%
b) Amitriptyline
63%
c) Moclobemide
4%
d) Selegiline
⭕️13. Which synapses are involved in depression?
Anonymous Quiz
1%
a) Dopaminergic synapses
64%
b) Serotoninergic synapses
3%
c) Cholinergic synapses
32%
d) All of the above
⭕️14. Block of which type of Monoamine Oxydase might be more selective for depression?
Anonymous Quiz
88%
a) MAO-A
6%
b) MAO-B
6%
c) Both MAO-A and MAO-B
0%
d) MAO-C
👏1
⭕️15. The principal mechanism of MAO inhibitor action is:
Anonymous Quiz
12%
a) Blocking the amine reuptake pumps, which permits to ⬆️ concentration of the NE at receptor site
72%
b) Blocking a major degradative pathway for the amine NE, more amines to accumulate in presynaptic
9%
c) Inhibition the storage of amine neurotransmitters in the vesicles of presynaptic nerve endings
7%
d) Antagonism of alfa2-norepinephrine receptors
👏1
⭕️16. The irreversible MAO inhibitors have a very high risk of developing:
Anonymous Quiz
6%
a) Respiratory depression
7%
b) Cardiovascular collapse and CNS depression
85%
c) Hypertensive reactions to tyramine ingested in food
2%
d) Potentially fatal agranulocytosis
👏1
⭕️17. The most dangerous pharmacodynamic interaction is between MAO inhibitors and:
Anonymous Quiz
8%
a) Selective serotonin reuptake inhibitors
2%
b) Tricyclics
1%
c) Sympathomimetics
89%
d) All of the above
❤1
⭕️18. Serotonin syndrome is a result of:
Anonymous Quiz
1%
a) Increased stores of monoamine
5%
b) Significant accumulation of amine neurotransmitters in the synapses
93%
c) Both a and b
0%
d) Depleted stores of biogenic amines
👏1
⭕️19. The therapeutic response to antidepressant drugs is usually over a period of:
Anonymous Quiz
6%
a) 2-3 days
92%
b) 2-3 weeks
1%
c) 24 hours
1%
d) 2-3 month
👏1
⭕️20. Which of the following antidepressants may have latency period as short as 48 hours?
Anonymous Quiz
71%
a) Tranylcypromine
6%
b) Imipramine
12%
c) Fluoxetine
11%
d) Amitrityline
👏1
⭕️21. Which of the following features do MAO inhibitors and tricyclic antidepressants have in common?
Anonymous Quiz
6%
a) Act postsynaptically to produce their effect
18%
b) Can precipitate hypotensive crises if certain foods are ingested
75%
c) Increase levels of biogenic amines
1%
d) Are useful for the manic phase of bipolar disorder
👏1
⭕️22. Tricyclic antidepressants are:
Anonymous Quiz
4%
a) Highly selective serotonin reuptake inhibitors
4%
b) Monoamine oxidase inhibitors
6%
c) Selective norepinephrine reuptake inhibitors
87%
d) Mixed norepinephrine and serotonin reuptake inhibitors
⭕️23. Which of the following autonomic nervous system effects is common for tricyclic antidepressants?
Anonymous Quiz
3%
a) Antimuscarinic action
1%
b) Antihistaminic action
2%
c) Alfa adrenoreceptor-blocking action
94%
d) All of the above
👏1
⭕️24. Indicate an effective antidepressant with minimal autonomic toxicity:
Anonymous Quiz
12%
a) Amitrityline
81%
b) Fluoxetine
4%
c) Imipramine
3%
d) Doxepin
⭕️25. Fluoxetine has fewer adverse effects because of:
Anonymous Quiz
1%
a) Mixed norepinephrine and serotonin reuptake inhibition
3%
b) Depleted stores of amine neurotransmitters
45%
c) Minimal binding to cholinergic, histaminic, and alfa-adrenergic receptors
51%
d) All of the above
⭕️26. Which of the following tricyclic and heterocyclic antidepressants has the greatest sedation?
Anonymous Quiz
2%
a) Doxepin
23%
b) Amitriptyline
2%
c) Trazodone
72%
d) All of the above
👏1
⭕️27. Which of the following tricyclic and heterocyclic agents has the least sedation?
Anonymous Quiz
54%
a) Protriptyline
4%
b) Trazodone
34%
c) Amitriptyline
9%
d) Mitrazapine
👏1
⭕️28. Indicate a tricyclic or a heterocyclic antidepressant having greatest antimuscarinic effects:
Anonymous Quiz
3%
a) Desipramine
82%
b) Amitriptyline
4%
c) Trazodone
10%
d) Mirtazapine
⭕️29. Indicate a tricyclic or a heterocyclic antidepressant having least antimuscarinic effects:
Anonymous Quiz
4%
a) Trazodone
3%
b) Buprorion
9%
c) Mirtazapine
85%
d) All of the above
⭕️30. Which of the following antidepressants has significant alfa2-adrenoreceptor antagonism?
Anonymous Quiz
15%
a) Amitriptyline
20%
b) Nefazodone
64%
c) Mirtazapine
1%
d) Doxepin
⭕️31. Indicate the main claim for an ideal antidepressant agent:
Anonymous Quiz
1%
a) A faster onset of action
0%
b) Fewer adverse sedative and autonomic effects
2%
c) Fewer toxicity when overdoses are taken
98%
d) All of the above