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✨طريقك نحو الرسوب✨ pinned «✨Mcq lec 5 / pharma.2 , 4th stage✨ *antidepressant drugs*»
⭕️1. The principal mechanism of action of antidepressant agents is:
Anonymous Quiz
3%
a) Stabilization of dopamine and beta-adrenergic receptors
15%
b) Inhibition of storage serotonin and epinephrine in the vesicles of presynaptic nerve endings
81%
c) Blocking epinephrine or serotonin reuptake pumps
1%
d) Stimulation of alfa2-norepinephrine receptors
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⭕️2. Which of the following agents is related to tricyclic antidepressants?
Anonymous Quiz
1%
a) Nefazodon
87%
b) Amitriptyline
11%
c) Fluoxetine
1%
d) Isocarboxazid
⭕️3. Indicate the second-generation heterocyclic drug:
Anonymous Quiz
75%
a) Maprotiline
9%
b) Imipramine
5%
c) Phenelzine
11%
d) Fluoxetine
⭕️4. Which of the following agents is related to the third-generation heterocyclic antidepressants?
Anonymous Quiz
8%
a) Amitriptyline
4%
b) Maprotiline
79%
c) Nefazodone
10%
d) Tranylcypromine
⭕️5. Which of the following antidepressants is a selective serotonin reuptake inhibitor?
Anonymous Quiz
5%
a) Phenelzine
5%
b) Desipramine
20%
c) Maprotiline
70%
d) Fluoxetine
⭕️6. Which of the following antidepressant agents is a selective inhibitor of norepinephrine reuptake?
Anonymous Quiz
3%
a) Fluvoxamine
56%
b) Maprotiline
21%
c) Amitriptyline
19%
d) Tranylcypromine
⭕️7. Indicate the antidepressant, which blocks the reuptake pumps for serotonin and norepinephrine:
Anonymous Quiz
76%
a) Amitriptyline
11%
b) Fluoxetine
7%
c) Maprotiline
6%
d) Phenelzine
⭕️8. Which of the following antidepressants is an unselective MAO blocker and produces extremely long-lasting inhibition of
the enzyme?
the enzyme?
Anonymous Quiz
15%
a) Moclobemide
78%
b) Tranylcypramine
3%
c) Selegiline
3%
d) Fluoxetine
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⭕️9. Indicate the irreversible MAO inhibitor, which is a hydrazide derivative:
Anonymous Quiz
16%
a) Moclobemide
5%
b) Selegiline
8%
c) Tranylcypramine
71%
d) Phenelzine
⭕️10. Which of the following MAO inhibitors has amphetamine-like activity and is related to nonhydrazide derivatives:
Anonymous Quiz
1%
a) Phenelzine
8%
b) Moclobemide
65%
c) Tranylcypramine
26%
d) All of the above
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⭕️11. Which of the following antidepressants is a selective short-acting MAO-A inhibitor?
Anonymous Quiz
15%
a) Maprotiline
18%
b) Amitriptyline
63%
c) Moclobemide
4%
d) Selegiline
⭕️13. Which synapses are involved in depression?
Anonymous Quiz
1%
a) Dopaminergic synapses
64%
b) Serotoninergic synapses
3%
c) Cholinergic synapses
32%
d) All of the above
⭕️14. Block of which type of Monoamine Oxydase might be more selective for depression?
Anonymous Quiz
88%
a) MAO-A
6%
b) MAO-B
6%
c) Both MAO-A and MAO-B
0%
d) MAO-C
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⭕️15. The principal mechanism of MAO inhibitor action is:
Anonymous Quiz
12%
a) Blocking the amine reuptake pumps, which permits to ⬆️ concentration of the NE at receptor site
72%
b) Blocking a major degradative pathway for the amine NE, more amines to accumulate in presynaptic
9%
c) Inhibition the storage of amine neurotransmitters in the vesicles of presynaptic nerve endings
7%
d) Antagonism of alfa2-norepinephrine receptors
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⭕️16. The irreversible MAO inhibitors have a very high risk of developing:
Anonymous Quiz
6%
a) Respiratory depression
7%
b) Cardiovascular collapse and CNS depression
85%
c) Hypertensive reactions to tyramine ingested in food
2%
d) Potentially fatal agranulocytosis
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⭕️17. The most dangerous pharmacodynamic interaction is between MAO inhibitors and:
Anonymous Quiz
8%
a) Selective serotonin reuptake inhibitors
2%
b) Tricyclics
1%
c) Sympathomimetics
89%
d) All of the above
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