⭕️43. Which of the following statements is correct for zolpidem?
Anonymous Quiz
2%
a) Causes minor effects on sleep patterns
2%
b) The risk of development of tolerance and dependence is less than with the use of hypnotic BZ.
5%
c) Has minimal muscle relaxing and anticonvulsant effects
91%
d) All of the above
⭕️44. Which agent exerts hypnotic activity with minimal muscle relaxing and anticonvulsant effects?
Anonymous Quiz
11%
a) Flurazepam
9%
b) Triazolam
78%
c) Zaleplon
2%
d) None of the above
⭕️46. Which of the following hypnotic drugs is used intravenously as anesthesia?
Anonymous Quiz
68%
a) Thiopental
16%
b) Phenobarbital
9%
c) Flurazepam
7%
d) Zolpidem
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⭕️47. Indicate the usual cause of death due to overdose of hypnotics:
Anonymous Quiz
95%
a) Depression of the medullar respiratory center
2%
b) Hypothermia
2%
c) Cerebral edema
1%
d) Status epilepticus
👏1
⭕️48. Toxic doses of hypnotics may cause a circulatory collapse as a result of:
Anonymous Quiz
2%
a) Blocking alfa adrenergic receptors
2%
b) Increasing vagal tone
45%
c) Action on the medullar vasomotor center
50%
d) All of the above
⭕️51. Select a hypnotic drug, which is an imidazopyridine derivative:
Anonymous Quiz
5%
a) Pentobarbital
7%
b) Temazepam
79%
c) Zolpidem
9%
d) Chloral hydrate
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⭕️52. Indicate the barbituric acid derivative, which has 4-5 days elimination half-life:
Anonymous Quiz
3%
a) Secobarbital
8%
b) Thiopental
88%
c) Phenobarbital
1%
d) Amobarbital
⭕️53. Indicate the hypnotic benzodiazepine, which has the shortest elimination half- life:
Anonymous Quiz
24%
a) Temazepam
51%
b) Triazolam
21%
c) Flurazepam
5%
d) Diazepam
⭕️54. Which of the following hypnotic drugs increases the activity of hepatic drug- metabolizing enzyme systems?
Anonymous Quiz
73%
a) Phenobarbital
9%
b) Zolpidem
13%
c) Flurazepam
5%
d) Zaleplon
❤1
⭕️55. Hepatic microsomal drug-metabolizing enzyme induction leads to:
Anonymous Quiz
95%
a) Barbiturate tolerance
2%
b) Cumulative effects
2%
c) Development of physical dependence
1%
d) “hangover” effects
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⭕️57. Barbiturates increase the rate of metabolism of:
Anonymous Quiz
2%
a) Anticoagulants
0%
b) Digitalis compounds
0%
c) Glucocorticoids
98%
d) All of the above
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⭕️59. Which of the following factors can influence the biodisposition of hypnotic agents?
Anonymous Quiz
1%
a) Alterations in the hepatic function resulting from a disease
1%
b) Old age
1%
c) Drug-induced increases or decreases in microsomal enzyme activities
97%
d) All of the above
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⭕️60. Which of the following hypnotics is preferred for elderly patients?
Anonymous Quiz
3%
a) Phenobarbital
8%
b) Flurozepam
88%
c) Temazepam
0%
d) Secobarbital
⭕️61. Which of the following hypnotics is preferred in patients with limited hepatic function?
Anonymous Quiz
70%
a) Zolpidem
4%
b) Amobarbital
20%
c) Flurozepam
7%
d) Pentobarbital
⭕️62. Indicate the mechanism of barbiturate action (at hypnotic doses):
Anonymous Quiz
81%
a) Increasing the duration of the GABA-gated Cl- channel openings
1%
b) Directly activating the chloride channels
3%
c) Increasing the frequency of Cl- channel opening events
15%
d) All of the above
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⭕️63. Which of the following hypnotic agents is a positive allosteric modulator of GABAA receptor function?
Anonymous Quiz
3%
a) Zaleplon
1%
b) Flurazepam
5%
c) Zolpidem
90%
d) All of the above
⭕️65. Which of the following hypnotic agents is able to interact with both BZ1 and BZ2 receptor subtypes?
Anonymous Quiz
4%
a) Zaleplon
3%
b) Phenobarbital
86%
c) Flurazepam
7%
d) Zolpidem
⭕️66. Flumazenil blocks the actions of:
Anonymous Quiz
7%
a) Phenobarbital
3%
b) Morphine
90%
c) Zolpidem
0%
d) Ethanol
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⭕️67. Which of the following agents blocks the chloride channel directly?
Anonymous Quiz
1%
a) Secobarbital
8%
b) Flumazenil
7%
c) Zaleplon
84%
d) Picrotoxin
⭕️69. Indicate the main claim for an ideal hypnotic agent:
Anonymous Quiz
3%
a) Rapid onset and sufficient duration of action
1%
b) Minor effects on sleep patterns
2%
c) Minimal “hangover” effects
84%
d) All of the above
10%
e) None of the above
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