⭕️40. Which one of the following hypnotic benzodiazepines is more likely to cause rebound insomnia?
Anonymous Quiz
44%
a) Triazolam
7%
b) Flurazepam
7%
c) Temazepam
42%
d) All of the above
⭕️41. Which of the following hypnotic benzodiazepines is more likely to cause “hangover” effects such as drowsiness,
dysphoria, and mental or motor depression the following day?
dysphoria, and mental or motor depression the following day?
Anonymous Quiz
13%
a) Temazepam
17%
b) Triazolam
66%
c) Flurazepam
3%
d) None of the above
⭕️42. Indicate the hypnotic drug, which binds selectively to the BZ1 receptor subtype, facilitating GABAergic inhibition:
Anonymous Quiz
4%
a) Thiopental
82%
b) Zolpidem
11%
c) Flurazepam
2%
d) Phenobarbital
⭕️43. Which of the following statements is correct for zolpidem?
Anonymous Quiz
2%
a) Causes minor effects on sleep patterns
2%
b) The risk of development of tolerance and dependence is less than with the use of hypnotic BZ.
5%
c) Has minimal muscle relaxing and anticonvulsant effects
91%
d) All of the above
⭕️44. Which agent exerts hypnotic activity with minimal muscle relaxing and anticonvulsant effects?
Anonymous Quiz
11%
a) Flurazepam
9%
b) Triazolam
78%
c) Zaleplon
2%
d) None of the above
⭕️46. Which of the following hypnotic drugs is used intravenously as anesthesia?
Anonymous Quiz
68%
a) Thiopental
16%
b) Phenobarbital
9%
c) Flurazepam
7%
d) Zolpidem
👏1
⭕️47. Indicate the usual cause of death due to overdose of hypnotics:
Anonymous Quiz
95%
a) Depression of the medullar respiratory center
2%
b) Hypothermia
2%
c) Cerebral edema
1%
d) Status epilepticus
👏1
⭕️48. Toxic doses of hypnotics may cause a circulatory collapse as a result of:
Anonymous Quiz
2%
a) Blocking alfa adrenergic receptors
2%
b) Increasing vagal tone
45%
c) Action on the medullar vasomotor center
50%
d) All of the above
⭕️51. Select a hypnotic drug, which is an imidazopyridine derivative:
Anonymous Quiz
5%
a) Pentobarbital
7%
b) Temazepam
79%
c) Zolpidem
9%
d) Chloral hydrate
👏1
⭕️52. Indicate the barbituric acid derivative, which has 4-5 days elimination half-life:
Anonymous Quiz
3%
a) Secobarbital
8%
b) Thiopental
88%
c) Phenobarbital
1%
d) Amobarbital
⭕️53. Indicate the hypnotic benzodiazepine, which has the shortest elimination half- life:
Anonymous Quiz
24%
a) Temazepam
51%
b) Triazolam
21%
c) Flurazepam
5%
d) Diazepam
⭕️54. Which of the following hypnotic drugs increases the activity of hepatic drug- metabolizing enzyme systems?
Anonymous Quiz
73%
a) Phenobarbital
9%
b) Zolpidem
13%
c) Flurazepam
5%
d) Zaleplon
❤1
⭕️55. Hepatic microsomal drug-metabolizing enzyme induction leads to:
Anonymous Quiz
95%
a) Barbiturate tolerance
2%
b) Cumulative effects
2%
c) Development of physical dependence
1%
d) “hangover” effects
👏1
⭕️57. Barbiturates increase the rate of metabolism of:
Anonymous Quiz
2%
a) Anticoagulants
0%
b) Digitalis compounds
0%
c) Glucocorticoids
98%
d) All of the above
👏1
⭕️59. Which of the following factors can influence the biodisposition of hypnotic agents?
Anonymous Quiz
1%
a) Alterations in the hepatic function resulting from a disease
1%
b) Old age
1%
c) Drug-induced increases or decreases in microsomal enzyme activities
97%
d) All of the above
👏1
⭕️60. Which of the following hypnotics is preferred for elderly patients?
Anonymous Quiz
3%
a) Phenobarbital
8%
b) Flurozepam
88%
c) Temazepam
0%
d) Secobarbital
⭕️61. Which of the following hypnotics is preferred in patients with limited hepatic function?
Anonymous Quiz
70%
a) Zolpidem
4%
b) Amobarbital
20%
c) Flurozepam
7%
d) Pentobarbital
⭕️62. Indicate the mechanism of barbiturate action (at hypnotic doses):
Anonymous Quiz
81%
a) Increasing the duration of the GABA-gated Cl- channel openings
1%
b) Directly activating the chloride channels
3%
c) Increasing the frequency of Cl- channel opening events
15%
d) All of the above
👏1
⭕️63. Which of the following hypnotic agents is a positive allosteric modulator of GABAA receptor function?
Anonymous Quiz
3%
a) Zaleplon
1%
b) Flurazepam
5%
c) Zolpidem
90%
d) All of the above
⭕️65. Which of the following hypnotic agents is able to interact with both BZ1 and BZ2 receptor subtypes?
Anonymous Quiz
4%
a) Zaleplon
3%
b) Phenobarbital
86%
c) Flurazepam
7%
d) Zolpidem