⭕️32. Barbiturates are being replaced by hypnotic benzodiazepines because of:
Anonymous Quiz
1%
a) Low therapeutic index
11%
b) Suppression in REM sleep
2%
c) High potential of physical dependence and abuse
86%
d) All of the above
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⭕️33. Which of the following benzodiazepines is used mainly for hypnosis?
Anonymous Quiz
5%
a) Clonozepam
7%
b) Lorazepam
80%
c) Flurazepam
9%
d) Midazolam
⭕️34. Indicate the main claim for an ideal hypnotic agent:
Anonymous Quiz
1%
a) Rapid onset and sufficient duration of action
1%
b) Minor effects on sleep patterns
2%
c) Minimal “hangover” effects
96%
d) All of the above
⭕️35. Which stage of sleep is responsible for the incidence of dreams?
Anonymous Quiz
80%
a) REM sleep
1%
b) Slow wave sleep
1%
c) Stage 2NREM sleep
17%
d) All of the above
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⭕️36. All of the hypnotic drugs induce:
Anonymous Quiz
21%
a) Increase the duration of REM sleep
75%
b) Decrease the duration of REM sleep
1%
c) Do not alter the duration of REM sleep
3%
d) Increase the duration of slow wave sleep
⭕️38. Although the benzodiazepines continue to be the agents of choice for insomnia, they have:
Anonymous Quiz
4%
a) The possibility of psychological and physiological dependence
1%
b) Synergistic depression of CNS with other drugs (especially alcohol)
1%
c) Residual drowsiness and daytime sedation
94%
d) All of the above
⭕️40. Which one of the following hypnotic benzodiazepines is more likely to cause rebound insomnia?
Anonymous Quiz
44%
a) Triazolam
7%
b) Flurazepam
7%
c) Temazepam
42%
d) All of the above
⭕️41. Which of the following hypnotic benzodiazepines is more likely to cause “hangover” effects such as drowsiness,
dysphoria, and mental or motor depression the following day?
dysphoria, and mental or motor depression the following day?
Anonymous Quiz
13%
a) Temazepam
17%
b) Triazolam
66%
c) Flurazepam
3%
d) None of the above
⭕️42. Indicate the hypnotic drug, which binds selectively to the BZ1 receptor subtype, facilitating GABAergic inhibition:
Anonymous Quiz
4%
a) Thiopental
82%
b) Zolpidem
11%
c) Flurazepam
2%
d) Phenobarbital
⭕️43. Which of the following statements is correct for zolpidem?
Anonymous Quiz
2%
a) Causes minor effects on sleep patterns
2%
b) The risk of development of tolerance and dependence is less than with the use of hypnotic BZ.
5%
c) Has minimal muscle relaxing and anticonvulsant effects
91%
d) All of the above
⭕️44. Which agent exerts hypnotic activity with minimal muscle relaxing and anticonvulsant effects?
Anonymous Quiz
11%
a) Flurazepam
9%
b) Triazolam
78%
c) Zaleplon
2%
d) None of the above
⭕️46. Which of the following hypnotic drugs is used intravenously as anesthesia?
Anonymous Quiz
68%
a) Thiopental
16%
b) Phenobarbital
9%
c) Flurazepam
7%
d) Zolpidem
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⭕️47. Indicate the usual cause of death due to overdose of hypnotics:
Anonymous Quiz
95%
a) Depression of the medullar respiratory center
2%
b) Hypothermia
2%
c) Cerebral edema
1%
d) Status epilepticus
👏1
⭕️48. Toxic doses of hypnotics may cause a circulatory collapse as a result of:
Anonymous Quiz
2%
a) Blocking alfa adrenergic receptors
2%
b) Increasing vagal tone
45%
c) Action on the medullar vasomotor center
50%
d) All of the above
⭕️51. Select a hypnotic drug, which is an imidazopyridine derivative:
Anonymous Quiz
5%
a) Pentobarbital
7%
b) Temazepam
79%
c) Zolpidem
9%
d) Chloral hydrate
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⭕️52. Indicate the barbituric acid derivative, which has 4-5 days elimination half-life:
Anonymous Quiz
3%
a) Secobarbital
8%
b) Thiopental
88%
c) Phenobarbital
1%
d) Amobarbital
⭕️53. Indicate the hypnotic benzodiazepine, which has the shortest elimination half- life:
Anonymous Quiz
24%
a) Temazepam
51%
b) Triazolam
21%
c) Flurazepam
5%
d) Diazepam
⭕️54. Which of the following hypnotic drugs increases the activity of hepatic drug- metabolizing enzyme systems?
Anonymous Quiz
73%
a) Phenobarbital
9%
b) Zolpidem
13%
c) Flurazepam
5%
d) Zaleplon
❤1
⭕️55. Hepatic microsomal drug-metabolizing enzyme induction leads to:
Anonymous Quiz
95%
a) Barbiturate tolerance
2%
b) Cumulative effects
2%
c) Development of physical dependence
1%
d) “hangover” effects
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