The elimination rate constant of oral absorption data can be determined by .residual method

Most two-compartment models assume that elimination occurs from the peripheral compartment because it contains the major sites of drug elimination...

At the postabsorption phase the rate of drug absorption is faster than the rate of elimination

Coadministering orange juice, colas, or other acidic beverages can facilitate the
absorption of some medication requiring .acidic enviroment

In edematous conditions, the total extracellular water decreases: this is reflected in a larger apparent VD value for adrug that is highly water soluble

Drug product performance : is defined as the release of the drug substance from the drug product either for local drug action or for drug absorption into the plasma for systemic therapeutic activity

A change in the crystal structure of the drug may cause cracking in a tablet or even
prevent granulation from being compressed .into a tablet

The diffusion coefficient, D, is defined as the amount of a drug that diffuses across
a membrane of a given unit area per unit time when the concentration gradient is unity

The nature and quantity of the diluent, binder disintegrant, lubricant and any wetting agent are important in the formulation of capsule dosage form

In in vitro studies of dissolution kinetics, the agitation rate is about 50 rpm (revolutions per minute).

Tablet coatings may be used for several reasons; all are true except:

is an-----
example of protein peptide drug generally
not given orally due to degradation and inadequate absorption in GIT

As the plasma drug concentration decreases during elimination, the rate of
elimination dDE/dt will----accordingly, but the clearance will be-----

Physiological factors affecting drug absorption in the gastrointestinal tract
include

Solubilization of aspirin may be increased by the addition of

All are effects of food on the bioavailability *:of a drug from drug product except

Factors that affect drug dissolution of a :solid oral dosage form include