The VD relates the concentration of drug in plasma (Cp) and the amount of drug in the body (DB)

Dissolution : is the process by which a solid drug substance becomes dissolved in a .solvent over time

Low concentrations of surfactant tend to form micelles with the drug and thus *.decrease the dissolution rate

Suspending agents that increase the
viscosity of the drug vehicle and thereby
diminish the rate of drug dissolution from suspension

For drugs that have very poor aqueous solubility, the rate at which the dosage form disintegrate is often the slowest step and therefore exerts a rate-limiting effect on
*.drug bioavailabilit

Phagocytosis refer to the engulfment of small solutes or fluid and it is a form of *.facilitated diffusion

The elimination rate constant of oral absorption data can be determined by .residual method

Most two-compartment models assume that elimination occurs from the peripheral compartment because it contains the major sites of drug elimination...

At the postabsorption phase the rate of drug absorption is faster than the rate of elimination

Coadministering orange juice, colas, or other acidic beverages can facilitate the
absorption of some medication requiring .acidic enviroment

In edematous conditions, the total extracellular water decreases: this is reflected in a larger apparent VD value for adrug that is highly water soluble

Drug product performance : is defined as the release of the drug substance from the drug product either for local drug action or for drug absorption into the plasma for systemic therapeutic activity

A change in the crystal structure of the drug may cause cracking in a tablet or even
prevent granulation from being compressed .into a tablet

The diffusion coefficient, D, is defined as the amount of a drug that diffuses across
a membrane of a given unit area per unit time when the concentration gradient is unity

The nature and quantity of the diluent, binder disintegrant, lubricant and any wetting agent are important in the formulation of capsule dosage form

In in vitro studies of dissolution kinetics, the agitation rate is about 50 rpm (revolutions per minute).