Gl motility tend to move the drug through the alimentary canal, so the drug may stay at the absorption site

Grapefruit juice often decreases bioavailabilitiy of many drugs that are substrate for cytochrome P-450*

Metoclopramide, all are correct except:

Drugs that are more lipid soluble have a larger
value of partition coefficient K.

stability-pH profile is a plot of the reaction rate constant for drug degradation versus pH.

Achlorhydria

Any decrease in mesenteric blood flow, as in the case of congestive heart failure, will ---- --- the rate of drug removal from the intestinal tract, thereby ----the rate of drug bioavailability. *

At steady state, the rate of change in the plasma drug concentration dCp/dt = 1

The VD relates the concentration of drug in plasma (Cp) and the amount of drug in the body (DB)

Dissolution : is the process by which a solid drug substance becomes dissolved in a .solvent over time

Low concentrations of surfactant tend to form micelles with the drug and thus *.decrease the dissolution rate

Suspending agents that increase the
viscosity of the drug vehicle and thereby
diminish the rate of drug dissolution from suspension

For drugs that have very poor aqueous solubility, the rate at which the dosage form disintegrate is often the slowest step and therefore exerts a rate-limiting effect on
*.drug bioavailabilit

Phagocytosis refer to the engulfment of small solutes or fluid and it is a form of *.facilitated diffusion

The elimination rate constant of oral absorption data can be determined by .residual method

Most two-compartment models assume that elimination occurs from the peripheral compartment because it contains the major sites of drug elimination...

At the postabsorption phase the rate of drug absorption is faster than the rate of elimination

Coadministering orange juice, colas, or other acidic beverages can facilitate the
absorption of some medication requiring .acidic enviroment

In edematous conditions, the total extracellular water decreases: this is reflected in a larger apparent VD value for adrug that is highly water soluble