Erythromycin has a pH- dependent stability
profile; it decomposes rapidly in alkaline medium.
profile; it decomposes rapidly in alkaline medium.
Anonymous Quiz
23%
T
77%
F
Some effects of food on the bioavailability of a drug from adrug product include:
Anonymous Quiz
4%
A change in the pH of the Gl tract.
4%
Stimulation of bile flow.
91%
Stimulation of bile flow, a change in the pH of the GI tract & increase in splanchnic blood flow.
1%
An increase in splanchnic blood flow
Enteric-coated tablets:
Anonymous Quiz
23%
reach the duodenum rapidly in the presence of food & the drug release and absorption of coated tab..
6%
the drug release and absorption of coated tablets increased by fatty meal.
69%
stay in the stomach for a longer period of time in the presence of food.
2%
reach the duodenum rapidly in the presence of food.
Factors associated with
the formulation of
aqueous suspension dosage forms that can influence the bioavailabilities of drugs: (all are True except)
the formulation of
aqueous suspension dosage forms that can influence the bioavailabilities of drugs: (all are True except)
Anonymous Quiz
6%
the particle size and effective surface area of the dispersed drug
11%
the crystal form of the drug
79%
the nature and quantity of the diluent, binder, disintegrant, lubricant and any wetting agent.
4%
the viscosity of the suspension.
❤2
According to the mechanism of drug absorption, if mannitol is dosed orally, it would be absorbed minimally and only throughh
Anonymous Quiz
9%
facilitated diffusion
82%
Paracellular absorption
4%
active transport
5%
Ion pair formation
The percent dissolved of erythromycin dihydrate is larger compared to the unhydrous form in phosphate buffer pH 7.4
Anonymous Quiz
24%
T
76%
F
Reduction of the particle size by milling to
micronized form improve the oral absorption of many steroids and drugs with low aqueous solubility
micronized form improve the oral absorption of many steroids and drugs with low aqueous solubility
Anonymous Quiz
84%
T
16%
F
❤1
or drugs that act as weak electrolytes, such as weak acids and bases, the extent of-------
influences the drug's diffusional permeability.
influences the drug's diffusional permeability.
Anonymous Quiz
7%
water solubility
5%
BBB
83%
Ionization
4%
Lipid sol.
Addition of disintegrant to the formulation ensure
rapid disintegration of the tablet and release of the drug.
rapid disintegration of the tablet and release of the drug.
Anonymous Quiz
87%
T
13%
F
The permeability of a drug at the absorption site into the systemic circulation is intimately
related to:
related to:
Anonymous Quiz
7%
the physical and biochemical properties of the cell membranes.
91%
molecular structure & properties of drug& the physical & biochemical properties of cell membranes.
0%
the molecular structure and properties of the O drug
1%
Non of the above
Gl motility tend to move the drug through the alimentary canal, so the drug may stay at the absorption site
Anonymous Quiz
18%
T
82%
F
Grapefruit juice often decreases bioavailabilitiy of many drugs that are substrate for cytochrome P-450*
Anonymous Quiz
29%
T
71%
F
❤1
Metoclopramide, all are correct except:
Anonymous Quiz
5%
reduces the effective time for the absorption of some drugs.
10%
digoxin absorption from a tablet is reduced by metoclopramide
67%
Allowing more time in the stomach for the tablet to dissolve
18%
is a drug that stimulates stomach contraction and increases intestinal peristalsis
Drugs that are more lipid soluble have a larger
value of partition coefficient K.
value of partition coefficient K.
Anonymous Quiz
89%
T
11%
F
stability-pH profile is a plot of the reaction rate constant for drug degradation versus pH.
Anonymous Quiz
83%
T
17%
F
Any decrease in mesenteric blood flow, as in the case of congestive heart failure, will ---- --- the rate of drug removal from the intestinal tract, thereby ----the rate of drug bioavailability. *
Anonymous Quiz
6%
increase, decrease
10%
decrease, increase.
5%
increase, increase
79%
decrease, decrease.
At steady state, the rate of change in the plasma drug concentration dCp/dt = 1
Anonymous Quiz
24%
T
76%
F
❤1
The VD relates the concentration of drug in plasma (Cp) and the amount of drug in the body (DB)
Anonymous Quiz
91%
T
9%
F
Dissolution : is the process by which a solid drug substance becomes dissolved in a .solvent over time
Anonymous Quiz
90%
T
10%
F
Low concentrations of surfactant tend to form micelles with the drug and thus *.decrease the dissolution rate
Anonymous Quiz
20%
T
80%
F