If we do a comparison of the effects of different types of food intake on the serum griseofulvin levels following 1 gm oral dose, greatest level seen with:
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10%
fasting.
83%
High fat
4%
high protein, no fat.
2%
oleomargarine 30 mg
1%
Non of the above
❤1
The Noyes-Whitney equation shows that dissolution in a flask may be influenced by the physicochemical characteristics of the drug, the formulation,
and the nature of the absorption membrane
and the nature of the absorption membrane
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42%
T
58%
F
When a drug is formulated as a powder filled capsules there is an enormous reduction in the effective surface
area of the drug.
area of the drug.
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32%
T
68%
F
Chloramphenicol concentration in the body
was found to be dependent on the percent of b-polymorph
inthe suspension.*
was found to be dependent on the percent of b-polymorph
inthe suspension.*
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95%
T
5%
F
Erythromycin has a pH- dependent stability
profile; it decomposes rapidly in alkaline medium.
profile; it decomposes rapidly in alkaline medium.
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23%
T
77%
F
Some effects of food on the bioavailability of a drug from adrug product include:
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4%
A change in the pH of the Gl tract.
4%
Stimulation of bile flow.
91%
Stimulation of bile flow, a change in the pH of the GI tract & increase in splanchnic blood flow.
1%
An increase in splanchnic blood flow
Enteric-coated tablets:
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23%
reach the duodenum rapidly in the presence of food & the drug release and absorption of coated tab..
6%
the drug release and absorption of coated tablets increased by fatty meal.
69%
stay in the stomach for a longer period of time in the presence of food.
2%
reach the duodenum rapidly in the presence of food.
Factors associated with
the formulation of
aqueous suspension dosage forms that can influence the bioavailabilities of drugs: (all are True except)
the formulation of
aqueous suspension dosage forms that can influence the bioavailabilities of drugs: (all are True except)
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6%
the particle size and effective surface area of the dispersed drug
11%
the crystal form of the drug
79%
the nature and quantity of the diluent, binder, disintegrant, lubricant and any wetting agent.
4%
the viscosity of the suspension.
❤2
According to the mechanism of drug absorption, if mannitol is dosed orally, it would be absorbed minimally and only throughh
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9%
facilitated diffusion
82%
Paracellular absorption
4%
active transport
5%
Ion pair formation
The percent dissolved of erythromycin dihydrate is larger compared to the unhydrous form in phosphate buffer pH 7.4
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24%
T
76%
F
Reduction of the particle size by milling to
micronized form improve the oral absorption of many steroids and drugs with low aqueous solubility
micronized form improve the oral absorption of many steroids and drugs with low aqueous solubility
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84%
T
16%
F
❤1
or drugs that act as weak electrolytes, such as weak acids and bases, the extent of-------
influences the drug's diffusional permeability.
influences the drug's diffusional permeability.
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7%
water solubility
5%
BBB
83%
Ionization
4%
Lipid sol.
Addition of disintegrant to the formulation ensure
rapid disintegration of the tablet and release of the drug.
rapid disintegration of the tablet and release of the drug.
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87%
T
13%
F
The permeability of a drug at the absorption site into the systemic circulation is intimately
related to:
related to:
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7%
the physical and biochemical properties of the cell membranes.
91%
molecular structure & properties of drug& the physical & biochemical properties of cell membranes.
0%
the molecular structure and properties of the O drug
1%
Non of the above
Gl motility tend to move the drug through the alimentary canal, so the drug may stay at the absorption site
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18%
T
82%
F
Grapefruit juice often decreases bioavailabilitiy of many drugs that are substrate for cytochrome P-450*
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29%
T
71%
F
❤1
Metoclopramide, all are correct except:
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5%
reduces the effective time for the absorption of some drugs.
10%
digoxin absorption from a tablet is reduced by metoclopramide
67%
Allowing more time in the stomach for the tablet to dissolve
18%
is a drug that stimulates stomach contraction and increases intestinal peristalsis
Drugs that are more lipid soluble have a larger
value of partition coefficient K.
value of partition coefficient K.
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89%
T
11%
F
stability-pH profile is a plot of the reaction rate constant for drug degradation versus pH.
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83%
T
17%
F
Any decrease in mesenteric blood flow, as in the case of congestive heart failure, will ---- --- the rate of drug removal from the intestinal tract, thereby ----the rate of drug bioavailability. *
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6%
increase, decrease
10%
decrease, increase.
5%
increase, increase
79%
decrease, decrease.