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valverde_et_al_2015_punctuated_equilibrium_in_the_large_scale_evolution.pdf
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4D Gaussian Splatting for Real-Time Dynamic Scene Rendering
Huazhong University of Science and Technology разом з Huawei Inc. опублікували код та статтю до свого методу 4D-GS (Gaussian Splatting), який перетворює звичайне відео у 3D відео (~30 FPS).
☑️ Google Colab.
☑️ Більше про Gaussian Splatting тут.
@eiaioi
Huazhong University of Science and Technology разом з Huawei Inc. опублікували код та статтю до свого методу 4D-GS (Gaussian Splatting), який перетворює звичайне відео у 3D відео (~30 FPS).
☑️ Google Colab.
☑️ Більше про Gaussian Splatting тут.
@eiaioi
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Forwarded from Link Crypt
Bupropion basically botched its landing, while the SSRIs really stuck theirs. Bupropion got FDA approval in 1985, while fluoxetine wasn't until 1987, so it had a head start. At this point, though, antidepressants weren't considered a big market (more of a specialty drug for an uncommon diagnosis, in an era when primary care had a healthy fear of tricyclics and MAOIs.) More importantly, bupropion got pulled in 1986 over seizure concerns. In these days, there was only instant-release bupropion, it was being dosed up to 600/day, and the elevated risk in eating disorders wasn't established, so the risk was pretty meaningful.
Bupropion got re-introduced in 1989 with a lower dose ceiling, but by this point fluoxetine was making a name for itself, and presumably bupropion was still tainted by seizure fears. The SR version didn't come along until 1996 and XL until 2003, so while the other SSRIs were coming to market and being marketed aggressively to various niches, bupropion was a TID-dosed drug specifically for MDD competing against once-a-day medications that also covered anxiety disorders. I don't think it was marketed nearly as effectively as the SSRIs. Remember also that sexual side effects took some years to really come to light, so bupropion's big selling point wasn't obvious at the time, and in the 80s/early 90s weight gain wasn't nearly as strong of a cultural concern in the U.S. (particularly as compared to getting depressed patients to eat something.)
In the modern world, bupropion/SSRIs/SNRIs/mirtazapine are all reasonable first-line options for MDD in the guidelines, depending on desired/undesired side effects and comorbidities. The old idea that bupropion will make anxious people too anxious is substantially overblown, and some smaller studies have actually found it helpful for anxiety disorders.
Bupropion got re-introduced in 1989 with a lower dose ceiling, but by this point fluoxetine was making a name for itself, and presumably bupropion was still tainted by seizure fears. The SR version didn't come along until 1996 and XL until 2003, so while the other SSRIs were coming to market and being marketed aggressively to various niches, bupropion was a TID-dosed drug specifically for MDD competing against once-a-day medications that also covered anxiety disorders. I don't think it was marketed nearly as effectively as the SSRIs. Remember also that sexual side effects took some years to really come to light, so bupropion's big selling point wasn't obvious at the time, and in the 80s/early 90s weight gain wasn't nearly as strong of a cultural concern in the U.S. (particularly as compared to getting depressed patients to eat something.)
In the modern world, bupropion/SSRIs/SNRIs/mirtazapine are all reasonable first-line options for MDD in the guidelines, depending on desired/undesired side effects and comorbidities. The old idea that bupropion will make anxious people too anxious is substantially overblown, and some smaller studies have actually found it helpful for anxiety disorders.
Forwarded from Цуберок 🇺🇦 #УкрТґ
Cells Inside Living Embryos Use Tiny Tubes to Mail Packages to One Another : ScienceAlert
https://www.sciencealert.com/cells-inside-living-embryos-use-tiny-tubes-to-mail-packages-to-one-another
https://www.sciencealert.com/cells-inside-living-embryos-use-tiny-tubes-to-mail-packages-to-one-another
ScienceAlert
Cells Inside Living Embryos Use Tiny Tubes to Mail Packages to One Another
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