الإجابة:

Hemophilia A
سيولة الدم النوع الوراثي لنقص عامل التجلط الثامن 🩺📚🔻


تفاصيل 📑✅🩵

The patient’s major symptoms are tied to a deficiency
in the clotting process. Clot formation is a complex
process, involving numerous plasma protein clotting
factors, platelets, and red blood cells.

The clotting cascade
🚑🚑🚑

results in the formation of a
fibrin mesh that can trap platelets and red blood cells
to form a blood clot.

The 16 different blood clotting
factors participate in either an extrinsic pathway
and/or an intrinsic pathway.

The extrinsic pathway 💊👇
requires an external stimulus, such as contact of the
blood with the damaged portion of the vascular endothelial or blood contact with thromboplastin in the
tissue spaces.

The intrinsic pathway 🏭🧠

can be activated
by vascular stasis, trauma to the blood, or contact with
collagen.

The ability to clot normally causes the loss
of red blood cells from the circulation into both tissue
spaces, joints, and the gastrointestinal tract.

Hemophilia A 🩸

results from a hereditary deficiency
in clotting factor VIII.
The inheritance pattern is
characterized as X-linked recessive, which means the

disease is clinically significant in males but females can
be carriers.
Females, however, can exhibit the disease
if they are the offspring of a hemophiliac father and a
carrier mother.

Factor VIII is a key component in the intrinsic

clotting pathway. In its absence, the clotting cascade is
impaired. The coagulation panel confirms this, as the
factor VIII
:C level is abnormally low.
The normal circulating levels of von Willebrand factor antigen rule
out another common congenital bleeding disorder,

von Willebrand’s disease
The remaining measures of coagulation prothrombin time, bleeding time, and fibrinogen
level—are normal.

This indicates that the clotting
factor deficiency is limited only to factor VIII. The

low hematocrit results from an increased loss of red
blood cells through hemorrhage. The normal platelet
levels indicate that platelet plug formation is likely
normal.

Multiple 🩵🩺📚

A 25-year-old man comes to his primary care physician
complaining of oral
bleeding 🩸 🩸 🩸

The patient has been on low molecular weight heparin for the past 2 years after 💊💊💊

the diagnosis of a pulmonary embolism 🚑🚑🚑

يقول أحد العارفين من باب النصيحة
التي يصدقها العقل 🧠

أعمل لدنياك بقدر بقائك فيها ، وأعمل لآخرتك قد بقائك فيها 👌

وينصح أحدهم بما يحمله القلب من هموم 🫀
ولحياتنا الدنيا في هذا العصر من أشغال ، يقول

على الأقل أن لم تسعى لآخرتك أكثر من دنياك ، فلا تؤثر دنياك على آخرتك ، فعليك بالعدل وهذا أقل القليل

نسأل الله التوفيق ، جاهد نفسك ، تكن موفقاً إن شاء الله عند الجهاد الحقيقي ✅ 🔥
تذكير صيام الخميس ، شارك تؤجر
وذكر غيرك 🩵 🚑
🌹🌹🌹🩺🥼

الإجابة 🔥🩺 نقص الصفائح الدموية
HIT (Heparin-induced thrombocytopenia): Positive
antibody assay

DIAGNOSIS 🚑

The primary symptoms of this patient are all related
to impaired platelet function. Platelets are usually

capable of sealing small breaks in blood vessels without
causing activation of the clotting cascade. When platelets encounter a damaged vascular endothelial cell, the

platelets aggregate and form a platelet plug, sealing
the damaged vessel. Impaired platelet function can
cause prolonged bleeding, and the bleeding results in
the appearance of small red dots on the skin and in the

mouth (petechiae). It can also cause the appearance of
somewhat larger or red purple dots (purpura) or even

larger hemorrhagic bullae.
Platelets are fragments of megakaryocytes that play
two roles in hemostasis. They form a platelet plug to
seal small openings in blood vessels (temporary hemo-
stasis) and contribute platelet factor III to the coagulation cascade.
The formation of the fibrin clot helps to
reinforce the platelet plug and to occlude larger areas
of damage.
Damage to the endothelium of the blood vessel
allows blood to come in contact with collagen.

A 50-year-old man comes to his family physician complaining of fatigue.🫥

The patient indicates that climbing the stairs leaves him short of breath and that this has been getting progressively worse over the past month. 🏞

He does not participate in any regular exercise.⛓
The patient works in a stressful job and to relieve stress the patient smokes, drinks 6 cups of coffee a day, and has two or three alcoholic drinks ☕️

after work. He has been taking aspirin for the last 6 months for frequent stomach pain. 🍔

The patient has decreased caloric intake for the past 3 months in an effort to lose weight, with moderate success
🩺🥼📑 🩸

‏غداً صيام الإثنين 🩵 🇵🇸 🔻
‏ صوم يوم في سبيل الله يُبعدك عن النار
‏ سبعين خريفاً ، عمل يسير ، وأجر عظيم .

السلام عليكم ورحمة الله وبركاته 🩵🥼🩺📚

أريد التحدث عن موضوع ولعل البعض سيختلف معي ، والسبب هو تلبيس الشيطان علينا جميعاً في كثير من الأبواب
ومنها هذا الباب
في هذه الجزئية الخاصة
بنا كـ طلبة ،

لكن لابد من التحدث وتوضيح الأمور ، وهذا لا يدل على الكمال، بل بالعكس يدل على أننا جميعاً مقصرون ، ولولا ستر الله علينا 📑
وهذا أيضاً لا يدل على أننا قد طبقنا كل شي ،
ولكن نجاهد أنفسنا على الصح وما أمر الله
حتى ولو لديك تقصير في جانب ثاني
جاهد نفسك خطوة بخطوة ، والله سيكون
عوناً لنا جميعاً ،

﴿ وَالَّذِينَ جَاهَدُوا فِينَا لَنَهْدِيَنَّهُمْ سُبُلَنَا ۚ وَإِنَّ اللَّهَ لَمَعَ الْمُحْسِنِينَ﴾
[ العنكبوت: 69]

لابد من النصيحة 🚑🩵