#COPD exacerbations lead to lung #function decline, particularly among those with mild COPD
https://www.sciencedaily.com/releases/2016/09/160908120352.htm
Acute exacerbations of chronic obstructive pulmonary disease, or COPD, are associated with significant long-term lung function loss, according to research published online, ahead of print in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
https://www.sciencedaily.com/releases/2016/09/160908120352.htm
Acute exacerbations of chronic obstructive pulmonary disease, or COPD, are associated with significant long-term lung function loss, according to research published online, ahead of print in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.
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The importance of measuring hand and foot #function over the disease course in #rheumatoid arthritis: An eight‐year follow‐up study
https://onlinelibrary.wiley.com/doi/10.1002/acr.23764
To assess function using the Signals of Functional Impairment (SOFI) instrument over eight years and to study clinical variables associated with the change. Also to study change over time of the SOFI items.
During the first year, there was a mean improvement in SOFI of 2.7 (SD 5.7) (p<0.001). Worse scores in DAS28 and HAQ at baseline were associated with this improvement (r2≤ 0.11). During the next seven years, there was a mean deterioration in SOFI of 1.5 (SD 4.9) (p<0.001). Based on change scores, finger flexion, pincer grip, and toe‐standing were the most important items to measure, explaining 58–61% of the total SOFI score and were also associated with radiographic changes at the eight‐year follow‐up.
Conclusion
Function as assessed with SOFI improved during the first year in patients with early RA, but it deteriorated slowly thereafter. Impaired hand and foot tasks were associated with joint destruction at the eight‐year follow‐up. Measures of hand and foot function will complement self‐reported and medical data both in clinical work and in long‐term research studies.
The importance of measuring hand and foot #function over the disease course in #rheumatoid arthritis: An eight‐year follow‐up study
https://onlinelibrary.wiley.com/doi/10.1002/acr.23764
To assess function using the Signals of Functional Impairment (SOFI) instrument over eight years and to study clinical variables associated with the change. Also to study change over time of the SOFI items.
During the first year, there was a mean improvement in SOFI of 2.7 (SD 5.7) (p<0.001). Worse scores in DAS28 and HAQ at baseline were associated with this improvement (r2≤ 0.11). During the next seven years, there was a mean deterioration in SOFI of 1.5 (SD 4.9) (p<0.001). Based on change scores, finger flexion, pincer grip, and toe‐standing were the most important items to measure, explaining 58–61% of the total SOFI score and were also associated with radiographic changes at the eight‐year follow‐up.
Conclusion
Function as assessed with SOFI improved during the first year in patients with early RA, but it deteriorated slowly thereafter. Impaired hand and foot tasks were associated with joint destruction at the eight‐year follow‐up. Measures of hand and foot function will complement self‐reported and medical data both in clinical work and in long‐term research studies.