Premature #Mortality Among Patients Recently Discharged From Their First Inpatient #Psychiatric Treatment
http://jamanetwork.com/journals/jamapsychiatry/article-abstract/2608758
Because the risk of premature death from a range of natural and unnatural causes is markedly elevated for this patient population, clinicians, academics, and public health specialists need to carefully consider the multiple mechanisms for premature death that are likely implicated. Clinicians may help protect patients after discharge by serving as a liaison between primary and secondary health services to ensure they are receiving holistic care. Early intervention programs for drug and alcohol misuse could substantially decrease the greatly elevated mortality risk among these patients.
http://jamanetwork.com/journals/jamapsychiatry/article-abstract/2608758
Because the risk of premature death from a range of natural and unnatural causes is markedly elevated for this patient population, clinicians, academics, and public health specialists need to carefully consider the multiple mechanisms for premature death that are likely implicated. Clinicians may help protect patients after discharge by serving as a liaison between primary and secondary health services to ensure they are receiving holistic care. Early intervention programs for drug and alcohol misuse could substantially decrease the greatly elevated mortality risk among these patients.
Jamanetwork
Premature Mortality After Recent Discharge From Inpatient Psychiatric Treatment
This study investigates the risks and causes of death for premature mortality among Danish patients within the first year of discharge from their first treatment at an inpatient psychiatric facility.
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Early life #experiences and social cognition in major #psychiatric disorders: A systematic review
https://www.sciencedirect.com/science/article/pii/S0924933818301305?via%3Dihub
A total of 25 studies were included in the systematic review with the quality assessment scores ranging from 3 to 6 (out of 6). The vast majority of the studies reviewed showed a significant association between early childhood social experience, including both insecure attachment and adversity relating to neglect or abuse, and poorer social cognitive performance.
Conclusion
We discuss these findings in the context of an attachment model, suggesting that childhood social adversity may result in poor internal working models, selective attention toward emotional stimuli and greater difficulties with emotional self-regulation. We outline some of the steps required to translate this understanding of social cognitive dysfunction in major psychiatric disorders into a target for interventions that mitigate the adverse effects of childhood maltreatment and poor parental attachment on social cognition
Early life #experiences and social cognition in major #psychiatric disorders: A systematic review
https://www.sciencedirect.com/science/article/pii/S0924933818301305?via%3Dihub
A total of 25 studies were included in the systematic review with the quality assessment scores ranging from 3 to 6 (out of 6). The vast majority of the studies reviewed showed a significant association between early childhood social experience, including both insecure attachment and adversity relating to neglect or abuse, and poorer social cognitive performance.
Conclusion
We discuss these findings in the context of an attachment model, suggesting that childhood social adversity may result in poor internal working models, selective attention toward emotional stimuli and greater difficulties with emotional self-regulation. We outline some of the steps required to translate this understanding of social cognitive dysfunction in major psychiatric disorders into a target for interventions that mitigate the adverse effects of childhood maltreatment and poor parental attachment on social cognition
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Childhood #seizures and risk of #psychiatric disorders in adolescence and early adulthood: a Danish nationwide cohort study
https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(18)30351-1/fulltext
The risk of any psychiatric disorder was raised in individuals with a history of febrile seizures (hazard ratio HR 1·12, 95% CI 1·08–1·17), epilepsy (1·34, 1·25–1·44), or both disorders (1·50, 1·28–1·75). Excess risk of psychiatric illness associated with childhood seizures was present across a range of different disorders, most notably schizophrenia but also anxiety and mood disorders. Associations did not differ between males and females (p=0·30) but increased with a growing number of admissions for febrile seizures (p<0·0001) and with later onset of childhood epilepsy (p<0·0001).
Interpretation
Children with epilepsy and febrile seizures—with and without concomitant epilepsy—are at increased risk of developing a broad range of psychiatric disorders in later life. Clarification of the underlying mechanisms attributable to these associations is needed to identify potential options for prevention
Childhood #seizures and risk of #psychiatric disorders in adolescence and early adulthood: a Danish nationwide cohort study
https://www.thelancet.com/journals/lanchi/article/PIIS2352-4642(18)30351-1/fulltext
The risk of any psychiatric disorder was raised in individuals with a history of febrile seizures (hazard ratio HR 1·12, 95% CI 1·08–1·17), epilepsy (1·34, 1·25–1·44), or both disorders (1·50, 1·28–1·75). Excess risk of psychiatric illness associated with childhood seizures was present across a range of different disorders, most notably schizophrenia but also anxiety and mood disorders. Associations did not differ between males and females (p=0·30) but increased with a growing number of admissions for febrile seizures (p<0·0001) and with later onset of childhood epilepsy (p<0·0001).
Interpretation
Children with epilepsy and febrile seizures—with and without concomitant epilepsy—are at increased risk of developing a broad range of psychiatric disorders in later life. Clarification of the underlying mechanisms attributable to these associations is needed to identify potential options for prevention
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Association of Hydroxylmethyl Glutaryl Coenzyme A Reductase Inhibitors, L-Type #Calcium Channel Antagonists, and Biguanides With Rates of #Psychiatric Hospitalization and Self-Harm in Individuals With Serious Mental Illness
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2719703
Drug repurposing is potentially cost-effective, low risk, and necessary in psychiatric drug development. The availability of large, routine data sets provides the opportunity to evaluate the potential for currently used medication to benefit people with serious mental illness (SMI).
To determine whether hydroxylmethyl glutaryl coenzyme A reductase inhibitors (HMG-CoA RIs), L-type calcium channel (LTCC) antagonists, and biguanides are associated with reduced psychiatric hospitalization and self-harm in individuals with SMI.
Conclusions and Relevance This study provides additional evidence that exposure to HMG-CoA RIs, LTCC antagonists, and biguanides might lead to improved outcomes for individuals with SMI. Given the well-known adverse event profiles of these agents, they should be further investigated as repurposed agents for psychiatric symptoms.
Association of Hydroxylmethyl Glutaryl Coenzyme A Reductase Inhibitors, L-Type #Calcium Channel Antagonists, and Biguanides With Rates of #Psychiatric Hospitalization and Self-Harm in Individuals With Serious Mental Illness
https://jamanetwork.com/journals/jamapsychiatry/fullarticle/2719703
Drug repurposing is potentially cost-effective, low risk, and necessary in psychiatric drug development. The availability of large, routine data sets provides the opportunity to evaluate the potential for currently used medication to benefit people with serious mental illness (SMI).
To determine whether hydroxylmethyl glutaryl coenzyme A reductase inhibitors (HMG-CoA RIs), L-type calcium channel (LTCC) antagonists, and biguanides are associated with reduced psychiatric hospitalization and self-harm in individuals with SMI.
Conclusions and Relevance This study provides additional evidence that exposure to HMG-CoA RIs, LTCC antagonists, and biguanides might lead to improved outcomes for individuals with SMI. Given the well-known adverse event profiles of these agents, they should be further investigated as repurposed agents for psychiatric symptoms.
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Multicomponent #Frailty Assessment Tools for Older People with #Psychiatric Disorders: A Systematic Review
https://onlinelibrary.wiley.com/doi/abs/10.1111/jgs.15710
Of the 48 multicomponent frailty assessment tools identified, no tool had been developed for, or validated in, older adult populations with a psychiatric disorder. Overall, 20 of 48 frailty assessment tools contained a psychological assessment domain, with 17 of 48 tools citing the presence of depressed mood and/or anxiety as a frailty indicator. Common areas of construct overlap in frailty assessment tools and DSM‐5 diagnostic criteria included weight loss (29 of 48) and fatigue (21 of 48).
Conclusions
Significant construct overlap exists between the indicators of frailty as conceptualized in existing frailty assessment tools and DSM‐5 diagnostic criteria for common psychiatric disorders including major depressive episode and generalized anxiety disorder that has the potential to confound frailty assessment results. Further research is necessary to establish a reliable and valid tool to assess frailty in this population.
Multicomponent #Frailty Assessment Tools for Older People with #Psychiatric Disorders: A Systematic Review
https://onlinelibrary.wiley.com/doi/abs/10.1111/jgs.15710
Of the 48 multicomponent frailty assessment tools identified, no tool had been developed for, or validated in, older adult populations with a psychiatric disorder. Overall, 20 of 48 frailty assessment tools contained a psychological assessment domain, with 17 of 48 tools citing the presence of depressed mood and/or anxiety as a frailty indicator. Common areas of construct overlap in frailty assessment tools and DSM‐5 diagnostic criteria included weight loss (29 of 48) and fatigue (21 of 48).
Conclusions
Significant construct overlap exists between the indicators of frailty as conceptualized in existing frailty assessment tools and DSM‐5 diagnostic criteria for common psychiatric disorders including major depressive episode and generalized anxiety disorder that has the potential to confound frailty assessment results. Further research is necessary to establish a reliable and valid tool to assess frailty in this population.
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Environmental #pollution is associated with increased risk of #psychiatric disorders in the US and Denmark
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000353
The search for the genetic factors underlying complex neuropsychiatric disorders has proceeded apace in the past decade. Despite some advances in identifying genetic variants associated with psychiatric disorders, most variants have small individual contributions to risk. By contrast, disease risk increase appears to be less subtle for disease-predisposing environmental insults
..Environmental Protection Agency (EPA) county-level environmental quality indices (EQIs) in the US and individual-level exposure to air pollution in Denmark were used to assess the association between pollution exposure and the risk of neuropsychiatric disorders. These results show that air pollution is significantly associated with increased risk of psychiatric disorders. We hypothesize that pollutants affect the human brain via neuroinflammatory pathways that have also been shown to cause depression-like phenotypes in animal studies.
Environmental #pollution is associated with increased risk of #psychiatric disorders in the US and Denmark
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3000353
The search for the genetic factors underlying complex neuropsychiatric disorders has proceeded apace in the past decade. Despite some advances in identifying genetic variants associated with psychiatric disorders, most variants have small individual contributions to risk. By contrast, disease risk increase appears to be less subtle for disease-predisposing environmental insults
..Environmental Protection Agency (EPA) county-level environmental quality indices (EQIs) in the US and individual-level exposure to air pollution in Denmark were used to assess the association between pollution exposure and the risk of neuropsychiatric disorders. These results show that air pollution is significantly associated with increased risk of psychiatric disorders. We hypothesize that pollutants affect the human brain via neuroinflammatory pathways that have also been shown to cause depression-like phenotypes in animal studies.
journals.plos.org
Environmental pollution is associated with increased risk of psychiatric disorders in the US and Denmark
Exploratory analyses of two independent datasets comprising 151 million Americans and 1.4 million Danes revealed that polluted air was associated with a significantly increased risk of psychiatric disorders, including bipolar disorder and schizophrenia.
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#Psychiatric Illness and Mortality in Hospitalized #ESKD Dialysis Patients
https://cjasn.asnjournals.org/content/early/2019/08/22/CJN.14191218
In the first ESKD year, 72% of elderly adults, 66% of adults and 64% of children had at least one hospitalization. Approximately 2% of adults and 1% of children were hospitalized with a primary psychiatric diagnosis. The most common primary psychiatric diagnoses were depression/affective disorder in adults and children, and organic disorders/dementias in elderly adults.
Prevalence of hospitalizations with psychiatric diagnoses increased over time across groups, primarily from secondary diagnoses. 19% of elderly adults, 25% of adults and 15% of children were hospitalized with a secondary psychiatric diagnosis. Hazards ratios of all-cause death were higher in all dialysis adults hospitalized with either primary (1.29; 1.26 to 1.32) or secondary (1.11; 1.10 to 1.12) psychiatric diagnoses than in those hospitalized without psychiatric diagnoses.
Conclusions Hospitalizations with psychiatric diagnoses are common in pediatric and adult ESKD patients, and are associated with subsequent higher mortality, compared with hospitalizations without psychiatric diagnoses. The prevalence of hospitalizations with psychiatric diagnoses likely underestimates the burden of mental illness in the population.
#Psychiatric Illness and Mortality in Hospitalized #ESKD Dialysis Patients
https://cjasn.asnjournals.org/content/early/2019/08/22/CJN.14191218
In the first ESKD year, 72% of elderly adults, 66% of adults and 64% of children had at least one hospitalization. Approximately 2% of adults and 1% of children were hospitalized with a primary psychiatric diagnosis. The most common primary psychiatric diagnoses were depression/affective disorder in adults and children, and organic disorders/dementias in elderly adults.
Prevalence of hospitalizations with psychiatric diagnoses increased over time across groups, primarily from secondary diagnoses. 19% of elderly adults, 25% of adults and 15% of children were hospitalized with a secondary psychiatric diagnosis. Hazards ratios of all-cause death were higher in all dialysis adults hospitalized with either primary (1.29; 1.26 to 1.32) or secondary (1.11; 1.10 to 1.12) psychiatric diagnoses than in those hospitalized without psychiatric diagnoses.
Conclusions Hospitalizations with psychiatric diagnoses are common in pediatric and adult ESKD patients, and are associated with subsequent higher mortality, compared with hospitalizations without psychiatric diagnoses. The prevalence of hospitalizations with psychiatric diagnoses likely underestimates the burden of mental illness in the population.
American Society of Nephrology
Psychiatric Illness and Mortality in Hospitalized ESKD Dialysis Patients
Background and objectives Limited existing data on psychiatric illness in ESKD patients suggest these diseases are common and burdensome, but under-recognized in clinical practice.
Design, setting, participants, & measurements We examined hospitalizations…
Design, setting, participants, & measurements We examined hospitalizations…
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Pediatric #Psychiatric Emergency Department Utilization and Fine #Particulate Matter: A Case-Crossover Study
Acute exposure to ambient particulate matter <2.5μm in aerodynamic diameter (PM2.5) has been associated with adult psychiatric exacerbations but has not been studied in children.
Results:
A 10-μg/m3 increase in PM2.5 was associated with a significant increase in any psychiatric ED utilization 1 [OR=1.07 (95% CI: 1.02, 1.12)] and 2 [OR=1.05 (95% CI: 1.00, 1.10)] d later. When stratified by visit reason, associations were significant for ED visits related to adjustment disorder {e.g., 1-d lag [OR=1.24 (95% CI: 1.02, 1.52)] and suicidality 1-d lag [OR=1.44 (95% CI: 1.03, 2.02)]}. There were significant differences according to community deprivation, with some lags showing stronger associations among children in high versus low deprivation areas for ED visits for anxiety {1-d lag [OR=1.39 (95% CI: 0.96, 2.01) vs. 0.85 (95% CI: 0.62, 1.17)] and suicidality same day [OR=1.98 (95% CI: 1.22, 3.23) vs. 0.93 (95% CI: 0.60, 1.45)]}. In contrast, for some lags, associations with ED visits for adjustment disorder were weaker for children in high-deprivation areas {1-d lag [OR=1.00 (95% CI: 0.76, 1.33) vs. 1.50 (95% CI: 1.16, 1.93)]}.
Discussion:
These findings warrant additional research to confirm the associations in other populations.
https://ehp.niehs.nih.gov/doi/10.1289/ehp4815
Pediatric #Psychiatric Emergency Department Utilization and Fine #Particulate Matter: A Case-Crossover Study
Acute exposure to ambient particulate matter <2.5μm in aerodynamic diameter (PM2.5) has been associated with adult psychiatric exacerbations but has not been studied in children.
Results:
A 10-μg/m3 increase in PM2.5 was associated with a significant increase in any psychiatric ED utilization 1 [OR=1.07 (95% CI: 1.02, 1.12)] and 2 [OR=1.05 (95% CI: 1.00, 1.10)] d later. When stratified by visit reason, associations were significant for ED visits related to adjustment disorder {e.g., 1-d lag [OR=1.24 (95% CI: 1.02, 1.52)] and suicidality 1-d lag [OR=1.44 (95% CI: 1.03, 2.02)]}. There were significant differences according to community deprivation, with some lags showing stronger associations among children in high versus low deprivation areas for ED visits for anxiety {1-d lag [OR=1.39 (95% CI: 0.96, 2.01) vs. 0.85 (95% CI: 0.62, 1.17)] and suicidality same day [OR=1.98 (95% CI: 1.22, 3.23) vs. 0.93 (95% CI: 0.60, 1.45)]}. In contrast, for some lags, associations with ED visits for adjustment disorder were weaker for children in high-deprivation areas {1-d lag [OR=1.00 (95% CI: 0.76, 1.33) vs. 1.50 (95% CI: 1.16, 1.93)]}.
Discussion:
These findings warrant additional research to confirm the associations in other populations.
https://ehp.niehs.nih.gov/doi/10.1289/ehp4815
Environmental Health Perspectives
Pediatric Psychiatric Emergency Department Utilization and Fine Particulate Matter: A Case-Crossover Study
Environmental Health Perspectives is an Open Access journal published by the National Institute of Environmental Health Sciences.
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Shared Genetic Loci Between Body #Mass Index and Major #Psychiatric Disorders
A Genome-wide Association Study
People with major psychiatric disorders (MPDs) have a 10- to 20-year shorter life span than the rest of the population, and this difference is mainly due to comorbid cardiovascular diseases..
schizophrenia (SCZ), bipolar disorder (BIP), major depression (MD) body mass index (BMI)
..Of the shared loci, 34% (73 of 213) in SCZ, 52% (36 of 69) in BIP, and 57% (56 of 99) in MD had risk alleles associated with higher BMI (conjunctional false discovery rate <0.05), while the rest had opposite directions of associations. Functional analyses indicated that the overlapping loci are involved in several pathways including neurodevelopment, neurotransmitter signaling, and intracellular processes, and the loci with concordant and opposite association directions pointed mostly to different pathways.
Conclusions and Relevance In this genome-wide association study, extensive polygenic overlap between BMI and SCZ, BIP, and MD were found, and 111 shared genetic loci were identified, implicating novel functional mechanisms. There was mixture of association directions in SCZ and BMI, albeit with a preponderance of discordant ones.
https://bit.ly/2ub4qN9
Shared Genetic Loci Between Body #Mass Index and Major #Psychiatric Disorders
A Genome-wide Association Study
People with major psychiatric disorders (MPDs) have a 10- to 20-year shorter life span than the rest of the population, and this difference is mainly due to comorbid cardiovascular diseases..
schizophrenia (SCZ), bipolar disorder (BIP), major depression (MD) body mass index (BMI)
..Of the shared loci, 34% (73 of 213) in SCZ, 52% (36 of 69) in BIP, and 57% (56 of 99) in MD had risk alleles associated with higher BMI (conjunctional false discovery rate <0.05), while the rest had opposite directions of associations. Functional analyses indicated that the overlapping loci are involved in several pathways including neurodevelopment, neurotransmitter signaling, and intracellular processes, and the loci with concordant and opposite association directions pointed mostly to different pathways.
Conclusions and Relevance In this genome-wide association study, extensive polygenic overlap between BMI and SCZ, BIP, and MD were found, and 111 shared genetic loci were identified, implicating novel functional mechanisms. There was mixture of association directions in SCZ and BMI, albeit with a preponderance of discordant ones.
https://bit.ly/2ub4qN9
Jamanetwork
Shared Genetic Loci Between Body Mass Index and Major Psychiatric Disorders
This genome-wide association study examines the extent of overlap between the genetic architectures of major psychiatric disorders and body mass index and identifies common genetic loci.
#ABCA13 dysfunction associated with #psychiatric disorders causes impaired cholesterol trafficking
https://2medical.news/2020/12/31/abca13-dysfunction-associated-with-psychiatric-disorders-causes-impaired-cholesterol-trafficking/
ATP-binding cassette subfamily A member 13 (ABCA13) is predicted to be the largest ABC protein, consisting of 5,058 amino acids and a long N-terminal region. Mutations in the ABCA13 gene were reported to increase the susceptibility to schizophrenia, bipolar disorder and major depression. However, little is known about the molecular functions of ABCA13 or how they associate with psychiatric disorders. Here, we examined the biochemical …
https://2medical.news/2020/12/31/abca13-dysfunction-associated-with-psychiatric-disorders-causes-impaired-cholesterol-trafficking/
ATP-binding cassette subfamily A member 13 (ABCA13) is predicted to be the largest ABC protein, consisting of 5,058 amino acids and a long N-terminal region. Mutations in the ABCA13 gene were reported to increase the susceptibility to schizophrenia, bipolar disorder and major depression. However, little is known about the molecular functions of ABCA13 or how they associate with psychiatric disorders. Here, we examined the biochemical …
The efficacy of real-time functional magnetic resonance imaging neurofeedback for #psychiatric illness: A meta-analysis of brain and behavioral outcomes
https://2medical.news/2021/03/04/the-efficacy-of-real-time-functional-magnetic-resonance-imaging-neurofeedback-for-psychiatric-illness-a-meta-analysis-of-brain-and-behavioral-outcomes/
Real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF) has gained popularity as an experimental treatment for a variety of psychiatric illnesses. However, there has yet to be a quantitative review regarding its efficacy. Here, we present the first meta-analysis of rtfMRI-NF for psychiatric disorders, evaluating its impact on brain and behavioral outcomes. Our literature review identified 17 studies and 105 effect sizes across brain and behavioral …
https://2medical.news/2021/03/04/the-efficacy-of-real-time-functional-magnetic-resonance-imaging-neurofeedback-for-psychiatric-illness-a-meta-analysis-of-brain-and-behavioral-outcomes/
Real-time functional magnetic resonance imaging neurofeedback (rtfMRI-NF) has gained popularity as an experimental treatment for a variety of psychiatric illnesses. However, there has yet to be a quantitative review regarding its efficacy. Here, we present the first meta-analysis of rtfMRI-NF for psychiatric disorders, evaluating its impact on brain and behavioral outcomes. Our literature review identified 17 studies and 105 effect sizes across brain and behavioral …
6-month neurological and #psychiatric outcomes in 236 379 survivors of #COVID-19: a retrospective cohort study using electronic health records
https://2medical.news/2021/04/10/6-month-neurological-and-psychiatric-outcomes-in-236%E2%80%89379-survivors-of-covid-19-a-retrospective-cohort-study-using-electronic-health-records/
Summary Background Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric diagnoses in patients in the 6 months following a COVID-19 diagnosis. Methods For this retrospective cohort study and time-to-event analysis, we used data …
https://2medical.news/2021/04/10/6-month-neurological-and-psychiatric-outcomes-in-236%E2%80%89379-survivors-of-covid-19-a-retrospective-cohort-study-using-electronic-health-records/
Summary Background Neurological and psychiatric sequelae of COVID-19 have been reported, but more data are needed to adequately assess the effects of COVID-19 on brain health. We aimed to provide robust estimates of incidence rates and relative risks of neurological and psychiatric diagnoses in patients in the 6 months following a COVID-19 diagnosis. Methods For this retrospective cohort study and time-to-event analysis, we used data …
#Aggressive incidents in #psychiatric hospitals on #heat days
https://2medical.news/2021/06/17/aggressive-incidents-in-psychiatric-hospitals-on-heat-days/
https://2medical.news/2021/06/17/aggressive-incidents-in-psychiatric-hospitals-on-heat-days/
2Medical.News
#Aggressive incidents in #psychiatric hospitals on #heat days
This study explores the relationship between temperature and the number of aggressive incidents and coercive interventions in the years 2007–2019 in six psychiatric hospitals in the south of the Ge…
Association of accelerometer-derived #sleep measures with lifetime #psychiatric diagnoses: A cross-sectional study of 89,205 participants from the UK Biobank
https://2medical.news/2021/10/20/association-of-accelerometer-derived-sleep-measures-with-lifetime-psychiatric-diagnoses-a-cross-sectional-study-of-89205-participants-from-the-uk-biobank/
https://2medical.news/2021/10/20/association-of-accelerometer-derived-sleep-measures-with-lifetime-psychiatric-diagnoses-a-cross-sectional-study-of-89205-participants-from-the-uk-biobank/
2Medical.News
Association of accelerometer-derived #sleep measures with lifetime #psychiatric diagnoses: A cross-sectional study of 89,205 participants…
Sleep problems are both symptoms of and modifiable risk factors for many psychiatric disorders. Wrist-worn accelerometers enable objective measurement of sleep at scale. Here, we aimed to examine t…
Association Between Genetic Risk for #Psychiatric Disorders and the Probability of Living in #Urban Settings
https://2medical.news/2021/11/02/association-between-genetic-risk-for-psychiatric-disorders-and-the-probability-of-living-in-urban-settings/
https://2medical.news/2021/11/02/association-between-genetic-risk-for-psychiatric-disorders-and-the-probability-of-living-in-urban-settings/
2Medical.News
Association Between Genetic Risk for #Psychiatric Disorders and the Probability of Living in #Urban Settings
Urban residence has been highlighted as an environmental risk factor for schizophrenia and, to a lesser extent, several other psychiatric disorders. However, few studies have explored genetic effec…
Regional, circuit and network heterogeneity of #brain abnormalities in #psychiatric disorders
https://2medical.news/2023/08/25/regional-circuit-and-network-heterogeneity-of-brain-abnormalities-in-psychiatric-disorders/
https://2medical.news/2023/08/25/regional-circuit-and-network-heterogeneity-of-brain-abnormalities-in-psychiatric-disorders/
2Medical.News
Regional, circuit and network heterogeneity of #brain abnormalities in #psychiatric disorders
The substantial individual heterogeneity that characterizes people with mental illness is often ignored by classical case–control research, which relies on group mean comparisons. Here we present a…