Gut #microbiota depletion by chronic #antibiotic treatment alters the sleep/wake architecture and #sleep EEG power spectra in mice
https://2medical.news/2020/12/26/gut-microbiota-depletion-by-chronic-antibiotic-treatment-alters-the-sleep-wake-architecture-and-sleep-eeg-power-spectra-in-mice-2/

Dysbiosis of the gut microbiota affects physiological processes, including brain functions, by altering the intestinal metabolism. Here we examined the effects of the gut microbiota on sleep/wake regulation. C57BL/6 male mice were treated with broad-spectrum antibiotics for 4 weeks to deplete their gut microbiota. Metabolome profiling of cecal contents in antibiotic-induced microbiota-depleted (AIMD) and control mice showed significant variations in the metabolism of amino acids …

Impact of Inappropriate #Antibiotic Therapy in Vancomycin-Resistant #Enterococcus Bacteremia
https://2medical.news/2021/01/14/impact-of-inappropriate-antibiotic-therapy-in-vancomycin-resistant-enterococcus-bacteremia/

Vancomycin-resistant Enterococcus (VRE) bacteremia has significant morbidity and mortality. Empiric antibiotic regimens for treating patients with risk factors for multidrug-resistant organisms may not have medications directed at treating VRE.. ..The inpatient, 30-day, and 1-year mortality rates from VRE bacteremia were 23%, 31%, and 59%, respectively. Only 19% patients were discharged home. Inappropriate antibiotics were prescribed in 19% patients. Appropriate antibiotics were prescribed in 81% patients …

#Antibiotic exposure during pregnancy and childhood #asthma: a national birth cohort study investigating timing of exposure and mode of delivery
https://2medical.news/2021/02/16/antibiotic-exposure-during-pregnancy-and-childhood-asthma-a-national-birth-cohort-study-investigating-timing-of-exposure-and-mode-of-delivery/

…A total of 5522 (17%) children were born to mothers exposed to antibiotics during pregnancy. In adjusted analyses, children born to exposed mothers had higher odds of asthma (OR 1.14, 95% CI 1.05 to 1.24). There was no association with antibiotic exposure in the first trimester (OR 1.02, 95% CI 0.83 to 1.26), but higher odds were observed for antibiotic exposure in the second to …

Delayed #antibiotic prescribing for #respiratory tract infections: individual patient data meta-analysis
http://2medical.news/2021/04/30/delayed-antibiotic-prescribing-for-respiratory-tract-infections-individual-patient-data-meta-analysis/

SO-25 Global rise in early-onset #colorectal cancer: An association with #antibiotic consumption?

https://2medical.news/2021/07/13/so-25-global-rise-in-early-onset-colorectal-cancer-an-association-with-antibiotic-consumption/

Effect of 7 vs 14 Days of #Antibiotic Therapy on Resolution of Symptoms Among Afebrile Men With #Urinary Tract InfectionA Randomized Clinical Trial

https://2medical.news/2021/08/06/effect-of-7-vs-14-days-of-antibiotic-therapy-on-resolution-of-symptoms-among-afebrile-men-with-urinary-tract-infectiona-randomized-clinical-trial/

Identification of #antibiotic pairs that evade concurrent resistance via a retrospective analysis of antimicrobial susceptibility test results

https://2medical.news/2021/08/14/identification-of-antibiotic-pairs-that-evade-concurrent-resistance-via-a-retrospective-analysis-of-antimicrobial-susceptibility-test-results/