Physical Therapy versus Glucocorticoid Injection for #Osteoarthritis of the Knee
https://2medical.news/2020/04/19/physical-therapy-versus-glucocorticoid-injection-for-osteoarthritis-of-the-knee/
..We enrolled 156 patients with a mean age of 56 years; 78 patients were assigned to each group. Baseline characteristics, including severity of pain and level of disability, were similar in the two groups. The mean (±SD) baseline WOMAC scores were 108.8±47.1 in the glucocorticoid injection group and 107.1±42.4 in the physical therapy group. At 1 year, the mean scores were 55.8±53.8 and 37.0±30.7, respectively …
https://2medical.news/2020/04/19/physical-therapy-versus-glucocorticoid-injection-for-osteoarthritis-of-the-knee/
..We enrolled 156 patients with a mean age of 56 years; 78 patients were assigned to each group. Baseline characteristics, including severity of pain and level of disability, were similar in the two groups. The mean (±SD) baseline WOMAC scores were 108.8±47.1 in the glucocorticoid injection group and 107.1±42.4 in the physical therapy group. At 1 year, the mean scores were 55.8±53.8 and 37.0±30.7, respectively …
Association between #statin use and incidence or progression of #osteoarthritis: Meta-analysis of observational studies
https://2medical.news/2020/05/04/association-between-statin-use-and-incidence-or-progression-of-osteoarthritis-meta-analysis-of-observational-studies/
..A total of 11 studies (679807 participants) were identified from the systematic literature search. No significant association between statin use and incidence (OR = 1.010; 95% CI: 0.968 to 1.055; P = 0.638) or progression (OR = 1.076; 95% CI: 0.824 to 1.405; P = 0.589) of OA was found in our meta-analysis. The meta-analysis according to the symptomatic or radiological OA also found no …
https://2medical.news/2020/05/04/association-between-statin-use-and-incidence-or-progression-of-osteoarthritis-meta-analysis-of-observational-studies/
..A total of 11 studies (679807 participants) were identified from the systematic literature search. No significant association between statin use and incidence (OR = 1.010; 95% CI: 0.968 to 1.055; P = 0.638) or progression (OR = 1.076; 95% CI: 0.824 to 1.405; P = 0.589) of OA was found in our meta-analysis. The meta-analysis according to the symptomatic or radiological OA also found no …
The Association of Pain Sensitization and Conditioned Pain Modulation to Pain Patterns in #Knee #Osteoarthritis
https://2medical.news/2020/09/11/the-association-of-pain-sensitization-and-conditioned-pain-modulation-to-pain-patterns-in-knee-osteoarthritis/
To examine the cross‐sectional association of ascending pain mechanisms (APM), implicated in pain sensitization (PS), and descending pain modulation with pain patterns and unpredictability of pain The Multicenter Osteoarthritis (OA) Study is a longitudinal cohort of older adults with or at risk of knee OA. Peripheral and central APM were assessed using quantitative sensory tests (QST); pressure pain thresholds (PPTs) using a handheld pressure algometer …
https://2medical.news/2020/09/11/the-association-of-pain-sensitization-and-conditioned-pain-modulation-to-pain-patterns-in-knee-osteoarthritis/
To examine the cross‐sectional association of ascending pain mechanisms (APM), implicated in pain sensitization (PS), and descending pain modulation with pain patterns and unpredictability of pain The Multicenter Osteoarthritis (OA) Study is a longitudinal cohort of older adults with or at risk of knee OA. Peripheral and central APM were assessed using quantitative sensory tests (QST); pressure pain thresholds (PPTs) using a handheld pressure algometer …
Effectiveness of #Curcuma longa Extract for the Treatment of Symptoms and Effusion–Synovitis of Knee #Osteoarthritis
https://2medical.news/2020/09/17/effectiveness-of-curcuma-longa-extract-for-the-treatment-of-symptoms-and-effusion-synovitis-of-knee-osteoarthritis/
To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion–synovitis in patients with symptomatic knee osteoarthritis and knee effusion–synovitis.. ..2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks. Measurements: The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion–synovitis volume on magnetic resonance imaging …
https://2medical.news/2020/09/17/effectiveness-of-curcuma-longa-extract-for-the-treatment-of-symptoms-and-effusion-synovitis-of-knee-osteoarthritis/
To determine the efficacy of Curcuma longa extract (CL) for reducing knee symptoms and effusion–synovitis in patients with symptomatic knee osteoarthritis and knee effusion–synovitis.. ..2 capsules of CL (n = 36) or matched placebo (n = 34) per day for 12 weeks. Measurements: The 2 primary outcomes were changes in knee pain on a visual analogue scale (VAS) and effusion–synovitis volume on magnetic resonance imaging …
#Acupuncture of different treatment frequencies in knee #osteoarthritis: a pilot randomised controlled trial
https://2medical.news/2020/10/27/acupuncture-of-different-treatment-frequencies-in-knee-osteoarthritis-a-pilot-randomised-controlled-trial/
This 16-week randomised controlled trial (8-week treatment followed by 8-week follow-up) evaluated the symptomatic improvement in patients with knee osteoarthritis on 3 sessions per week of acupuncture (TSWA) compared to 1 session per week of acupuncture (OSWA). Sixty participants were randomised to either the TSWA or the OSWA group in a 1:1 ratio. The primary outcome was response rate, defined as the percentage of participants …
https://2medical.news/2020/10/27/acupuncture-of-different-treatment-frequencies-in-knee-osteoarthritis-a-pilot-randomised-controlled-trial/
This 16-week randomised controlled trial (8-week treatment followed by 8-week follow-up) evaluated the symptomatic improvement in patients with knee osteoarthritis on 3 sessions per week of acupuncture (TSWA) compared to 1 session per week of acupuncture (OSWA). Sixty participants were randomised to either the TSWA or the OSWA group in a 1:1 ratio. The primary outcome was response rate, defined as the percentage of participants …
The Effect of Flat Flexible Versus Stable Supportive #Shoes on Knee #Osteoarthritis Symptoms
https://2medical.news/2021/01/14/the-effect-of-flat-flexible-versus-stable-supportive-shoes-on-knee-osteoarthritis-symptoms/
Experts recommend that persons with knee osteoarthritis wear stable supportive shoes; however, evidence suggests that flat flexible shoes may be more beneficial.. ..Of 164 participants recruited, 161 (98%) completed 6-month primary outcomes. No evidence was found that flat flexible shoes were superior to stable supportive shoes in primary outcomes. Evidence did show a between-group difference in change in pain favoring stable supportive shoes (mean difference, …
https://2medical.news/2021/01/14/the-effect-of-flat-flexible-versus-stable-supportive-shoes-on-knee-osteoarthritis-symptoms/
Experts recommend that persons with knee osteoarthritis wear stable supportive shoes; however, evidence suggests that flat flexible shoes may be more beneficial.. ..Of 164 participants recruited, 161 (98%) completed 6-month primary outcomes. No evidence was found that flat flexible shoes were superior to stable supportive shoes in primary outcomes. Evidence did show a between-group difference in change in pain favoring stable supportive shoes (mean difference, …
Efficacy and safety of #antidepressants for the treatment of back pain and #osteoarthritis: systematic review and meta-analysis
https://2medical.news/2021/01/24/efficacy-and-safety-of-antidepressants-for-the-treatment-of-back-pain-and-osteoarthritis-systematic-review-and-meta-analysis/
.. 33 trials (5318 participants) were included. Moderate certainty evidence showed that serotonin-noradrenaline reuptake inhibitors (SNRIs) reduced back pain (mean difference −5.30, 95% confidence interval −7.31 to −3.30) at 3-13 weeks and low certainty evidence that SNRIs reduced osteoarthritis pain (−9.72, −12.75 to −6.69) at 3-13 weeks. Very low certainty evidence showed that SNRIs reduced sciatica at two weeks or less (−18.60, −31.87 to −5.33) …
https://2medical.news/2021/01/24/efficacy-and-safety-of-antidepressants-for-the-treatment-of-back-pain-and-osteoarthritis-systematic-review-and-meta-analysis/
.. 33 trials (5318 participants) were included. Moderate certainty evidence showed that serotonin-noradrenaline reuptake inhibitors (SNRIs) reduced back pain (mean difference −5.30, 95% confidence interval −7.31 to −3.30) at 3-13 weeks and low certainty evidence that SNRIs reduced osteoarthritis pain (−9.72, −12.75 to −6.69) at 3-13 weeks. Very low certainty evidence showed that SNRIs reduced sciatica at two weeks or less (−18.60, −31.87 to −5.33) …
Association between current medication use and progression of radiographic #knee #osteoarthritis: data from the Osteoarthritis Initiative
https://2medical.news/2021/02/02/association-between-current-medication-use-and-progression-of-radiographic-knee-osteoarthritis-data-from-the-osteoarthritis-initiative/
Use of specific medications may accelerate the progression of radiographic knee osteoarthritis (RKOA). Our aim was to examine the effect of medication use on the progression of RKOA. Methods We used longitudinal data from the Osteoarthritis Initiative (OAI); an observational study of risk factors for knee OA. At baseline, we selected participants with RKOA (KL grade ≥2) and excluded those with a history of knee-related …
https://2medical.news/2021/02/02/association-between-current-medication-use-and-progression-of-radiographic-knee-osteoarthritis-data-from-the-osteoarthritis-initiative/
Use of specific medications may accelerate the progression of radiographic knee osteoarthritis (RKOA). Our aim was to examine the effect of medication use on the progression of RKOA. Methods We used longitudinal data from the Osteoarthritis Initiative (OAI); an observational study of risk factors for knee OA. At baseline, we selected participants with RKOA (KL grade ≥2) and excluded those with a history of knee-related …
Effect of High-Intensity Strength #Training on #Knee Pain and Knee Joint Compressive Forces Among Adults With Knee #Osteoarthritis
https://2medical.news/2021/02/18/effect-of-high-intensity-strength-training-on-knee-pain-and-knee-joint-compressive-forces-among-adults-with-knee-osteoarthritis/
Thigh muscle weakness is associated with knee discomfort and osteoarthritis disease progression. Little is known about the efficacy of high-intensity strength training in patients with knee osteoarthritis or whether it may worsen knee symptoms. Objective To determine whether high-intensity strength training reduces knee pain and knee joint compressive forces more than low-intensity strength training and more than attention control in patients with knee osteoarthritis. Design, …
https://2medical.news/2021/02/18/effect-of-high-intensity-strength-training-on-knee-pain-and-knee-joint-compressive-forces-among-adults-with-knee-osteoarthritis/
Thigh muscle weakness is associated with knee discomfort and osteoarthritis disease progression. Little is known about the efficacy of high-intensity strength training in patients with knee osteoarthritis or whether it may worsen knee symptoms. Objective To determine whether high-intensity strength training reduces knee pain and knee joint compressive forces more than low-intensity strength training and more than attention control in patients with knee osteoarthritis. Design, …
Effect of Telephone #Cognitive Behavioral Therapy for Insomnia in Older Adults With #Osteoarthritis Pain
https://2medical.news/2021/02/24/effect-of-telephone-cognitive-behavioral-therapy-for-insomnia-in-older-adults-with-osteoarthritis-pain/
Scalable delivery models of cognitive behavioral therapy for insomnia (CBT-I), an effective treatment, are needed for widespread implementation, particularly in rural and underserved populations lacking ready access to insomnia treatment. Objective To evaluate the effectiveness of telephone CBT-I vs education-only control (EOC) in older adults with moderate to severe osteoarthritis pain. Design, Setting, and Participants This is a randomized clinical trial of 327 participants 60 …
https://2medical.news/2021/02/24/effect-of-telephone-cognitive-behavioral-therapy-for-insomnia-in-older-adults-with-osteoarthritis-pain/
Scalable delivery models of cognitive behavioral therapy for insomnia (CBT-I), an effective treatment, are needed for widespread implementation, particularly in rural and underserved populations lacking ready access to insomnia treatment. Objective To evaluate the effectiveness of telephone CBT-I vs education-only control (EOC) in older adults with moderate to severe osteoarthritis pain. Design, Setting, and Participants This is a randomized clinical trial of 327 participants 60 …
The Value of Total #Knee Replacement in Patients With Knee #Osteoarthritis and a Body Mass Index of 40 kg/m2 or Greater A Cost-Effectiveness Analysis
https://2medical.news/2021/03/24/the-value-of-total-knee-replacement-in-patients-with-knee-osteoarthritis-and-a-body-mass-index-of-40-kg-m2-or-greater-a-cost-effectiveness-analysis/
Total knee replacement (TKR) is an effective and cost-effective strategy for treating end-stage knee osteoarthritis. Greater risk for complications among TKR recipients with a body mass index (BMI) of 40 kg/m2 or greater has raised concerns about the value of TKR in this population. Objective: To assess the value of TKR in recipients with a BMI of 40 kg/m2 or greater using a cost-effectiveness analysis. …
https://2medical.news/2021/03/24/the-value-of-total-knee-replacement-in-patients-with-knee-osteoarthritis-and-a-body-mass-index-of-40-kg-m2-or-greater-a-cost-effectiveness-analysis/
Total knee replacement (TKR) is an effective and cost-effective strategy for treating end-stage knee osteoarthritis. Greater risk for complications among TKR recipients with a body mass index (BMI) of 40 kg/m2 or greater has raised concerns about the value of TKR in this population. Objective: To assess the value of TKR in recipients with a BMI of 40 kg/m2 or greater using a cost-effectiveness analysis. …
Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain and function
https://2medical.news/2021/11/10/long-term-mortality-of-patients-with-osteoarthritis-after-joint-replacement-prognostic-value-of-pre-and-postoperative-pain-and-function/
https://2medical.news/2021/11/10/long-term-mortality-of-patients-with-osteoarthritis-after-joint-replacement-prognostic-value-of-pre-and-postoperative-pain-and-function/
2Medical.News
Long-term mortality of patients with #osteoarthritis after #joint replacement: Prognostic value of pre- and postoperative pain…
To investigate whether osteoarthritis (OA)–specific assessment values (i.e. Western Ontario and McMaster University Osteoarthritis Index [WOMAC]) and generic pain and function (visual analog scale …
An #osteoarthritis pathophysiological continuum revealed by molecular #biomarkers
https://2medical.news/2024/05/02/an-osteoarthritis-pathophysiological-continuum-revealed-by-molecular-biomarkers/
https://2medical.news/2024/05/02/an-osteoarthritis-pathophysiological-continuum-revealed-by-molecular-biomarkers/
2Medical.News
An #osteoarthritis pathophysiological continuum revealed by molecular #biomarkers
We aimed to identify serum biomarkers that predict knee osteoarthritis (OA) before the appearance of radiographic abnormalities in a cohort of 200 women. As few as six serum peptides, corresponding…