Recommendations for Management of Clinically Significant Drug-Drug #Interactions With #Statins and Select Agents Used in Patients With Cardiovascular Disease: A Scientific Statement From the American Heart Association
http://circ.ahajournals.org/content/early/2016/10/17/CIR.0000000000000456
http://circ.ahajournals.org/content/early/2016/10/17/CIR.0000000000000456
#Statins Shown to Reduce Risk of Death in People with Alcoholic #Cirrhosis
https://www.aasld.org/events-professional-development/liver-meeting/press/statins-shown-reduce-risk-death-people-alcoholic-cirrhosis
This study -- along with other similar studies -- strongly supports the hypothesis that these patients may benefit from statins, and a randomized study with placebo is the next natural step in the investigation of statins and cirrhosis
https://www.aasld.org/events-professional-development/liver-meeting/press/statins-shown-reduce-risk-death-people-alcoholic-cirrhosis
This study -- along with other similar studies -- strongly supports the hypothesis that these patients may benefit from statins, and a randomized study with placebo is the next natural step in the investigation of statins and cirrhosis
Comparative effect of #statins on the risk of incident #Alzheimer disease
http://n.neurology.org/content/early/2017/12/15/WNL.0000000000004818
Over the 18-year study period, we identified 465,085 statin users, including 7,669 patients who developed AD during 2,891,268 person-years of follow-up (incidence rate 2.65 95% CI 2.59–2.71 per 1,000 person-years). Compared to synthetic, fungus-derived statins were associated with an increased risk of AD (HR 1.09, 95% CI 1.03–1.15). Lipophilic statins also were associated with higher AD risk (HR 1.18, 95% CI 1.09–1.27) compared to hydrophilic statins, while statin potency did not modify the risk of AD (adjusted HR 1.03, 95% CI 0.98–1.08). The risk was further reduced in sensitivity analyses.
Conclusion Fungus-derived and lipophilic statins were not associated with decreased incidence of AD compared to synthetic and hydrophilic statins. The modest variations in the risk of incident AD observed between statin characteristics needs to be evaluated in future studies on their possible heterogeneous neuroprotective effect
http://n.neurology.org/content/early/2017/12/15/WNL.0000000000004818
Over the 18-year study period, we identified 465,085 statin users, including 7,669 patients who developed AD during 2,891,268 person-years of follow-up (incidence rate 2.65 95% CI 2.59–2.71 per 1,000 person-years). Compared to synthetic, fungus-derived statins were associated with an increased risk of AD (HR 1.09, 95% CI 1.03–1.15). Lipophilic statins also were associated with higher AD risk (HR 1.18, 95% CI 1.09–1.27) compared to hydrophilic statins, while statin potency did not modify the risk of AD (adjusted HR 1.03, 95% CI 0.98–1.08). The risk was further reduced in sensitivity analyses.
Conclusion Fungus-derived and lipophilic statins were not associated with decreased incidence of AD compared to synthetic and hydrophilic statins. The modest variations in the risk of incident AD observed between statin characteristics needs to be evaluated in future studies on their possible heterogeneous neuroprotective effect
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The role of #metformin and #statins in the incidence of epithelial ovarian #cancer in type 2 diabetes: a cohort and nested case–control study
https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/1471-0528.15151
In all, 303 women were diagnosed with ovarian cancer during the follow up. Compared with other forms of oral anti‐diabetic medication, metformin (HR 1.02, 95% CI: 0.72–1.45) was not found to be associated with the incidence of ovarian cancer. Neither was there evidence for statins to affect the incidence (HR 0.99, 95% CI: 0.78–1.25). In nested case–control analysis the results were essentially similar.
Conclusions
No evidence of an association between the use of metformin or statins and the incidence of ovarian cancer in women with T2D was found.
The role of #metformin and #statins in the incidence of epithelial ovarian #cancer in type 2 diabetes: a cohort and nested case–control study
https://obgyn.onlinelibrary.wiley.com/doi/abs/10.1111/1471-0528.15151
In all, 303 women were diagnosed with ovarian cancer during the follow up. Compared with other forms of oral anti‐diabetic medication, metformin (HR 1.02, 95% CI: 0.72–1.45) was not found to be associated with the incidence of ovarian cancer. Neither was there evidence for statins to affect the incidence (HR 0.99, 95% CI: 0.78–1.25). In nested case–control analysis the results were essentially similar.
Conclusions
No evidence of an association between the use of metformin or statins and the incidence of ovarian cancer in women with T2D was found.
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#Statins and Multiple Noncardiovascular Outcomes: Umbrella Review of Meta-analyses of Observational Studies and Randomized Controlled Trials
http://annals.org/aim/article-abstract/2706169/statins-multiple-noncardiovascular-outcomes-umbrella-review-meta-analyses-observational-studies
This review explored 278 unique non-CVD outcomes from 112 meta-analyses of observational studies and 144 meta-analyses of RCTs. For observational studies, no convincing (class I) evidence, 2 highly suggestive (class II) associations (decreased cancer mortality in patients with cancer and decreased exacerbation in patients with chronic obstructive #pulmonary disease), 21 suggestive (class III) associations, and 42 weak (class IV) associations were identified. One outcome from the RCTs (decreased all-cause mortality in patients with chronic kidney disease) attained a sufficient amount of evidence with no hints of bias. For adverse events, observational studies showed suggestive evidence that statins increase the risk for diabetes and myopathy. Among the RCTs, no statistically significant effects were found on myopathy, myalgia, or rhabdomyolysis.
The absence of convincing evidence of an association between statins and non-CVD outcomes supports leaving the current recommendations unchanged
#Statins and Multiple Noncardiovascular Outcomes: Umbrella Review of Meta-analyses of Observational Studies and Randomized Controlled Trials
http://annals.org/aim/article-abstract/2706169/statins-multiple-noncardiovascular-outcomes-umbrella-review-meta-analyses-observational-studies
This review explored 278 unique non-CVD outcomes from 112 meta-analyses of observational studies and 144 meta-analyses of RCTs. For observational studies, no convincing (class I) evidence, 2 highly suggestive (class II) associations (decreased cancer mortality in patients with cancer and decreased exacerbation in patients with chronic obstructive #pulmonary disease), 21 suggestive (class III) associations, and 42 weak (class IV) associations were identified. One outcome from the RCTs (decreased all-cause mortality in patients with chronic kidney disease) attained a sufficient amount of evidence with no hints of bias. For adverse events, observational studies showed suggestive evidence that statins increase the risk for diabetes and myopathy. Among the RCTs, no statistically significant effects were found on myopathy, myalgia, or rhabdomyolysis.
The absence of convincing evidence of an association between statins and non-CVD outcomes supports leaving the current recommendations unchanged
!!
Finding the Balance Between Benefits and Harms When Using #Statins for Primary Prevention of #cardiovascular Disease: A Modeling Study
http://annals.org/aim/article-abstract/2717730/finding-balance-between-benefits-harms-when-using-statins-primary-prevention
Younger men had net benefit at a lower 10-year risk for CVD than older men (14% for ages 40 to 44 years vs. 21% for ages 70 to 75 years). In women, the risk required for net benefit was higher (17% for ages 40 to 44 years vs. 22% for ages 70 to 75 years). Atorvastatin and rosuvastatin provided net benefit at lower 10-year risks than simvastatin and pravastatin
Statins provide net benefits at higher 10-year risks for CVD than are reflected in most current guidelines. In addition, the level of risk at which net benefit occurs varies considerably by age, sex, and statin type
Finding the Balance Between Benefits and Harms When Using #Statins for Primary Prevention of #cardiovascular Disease: A Modeling Study
http://annals.org/aim/article-abstract/2717730/finding-balance-between-benefits-harms-when-using-statins-primary-prevention
Younger men had net benefit at a lower 10-year risk for CVD than older men (14% for ages 40 to 44 years vs. 21% for ages 70 to 75 years). In women, the risk required for net benefit was higher (17% for ages 40 to 44 years vs. 22% for ages 70 to 75 years). Atorvastatin and rosuvastatin provided net benefit at lower 10-year risks than simvastatin and pravastatin
Statins provide net benefits at higher 10-year risks for CVD than are reflected in most current guidelines. In addition, the level of risk at which net benefit occurs varies considerably by age, sex, and statin type
!!
Lipophilic #Statins and Risk for #Hepatocellular Carcinoma and Death in Patients With Chronic Viral Hepatitis: Results From a Nationwide Swedish Population
https://annals.org/aim/article-abstract/2748619/lipophilic-statins-risk-hepatocellular-carcinoma-death-patients-chronic-viral-hepatitis
..Compared with matched nonusers, 10-year HCC risk was significantly lower among lipophilic statin users (8.1% vs. 3.3%; absolute risk difference [RD], −4.8 percentage points [95% CI, −6.2 to −3.3 percentage points]; adjusted subdistribution hazard ratio [aHR], 0.56 [CI, 0.41 to 0.79]) but not hydrophilic statin users (8.0% vs. 6.8%; RD, −1.2 percentage points [CI, −2.6 to 0.4 percentage points]; aHR, 0.95 [CI, 0.86 to 1.08)..
In a nationwide viral hepatitis cohort, lipophilic statins were associated with significantly reduced HCC incidence and mortality. An association between hydrophilic statins and reduced risk for HCC was not found. Further research is needed to determine whether lipophilic statin therapy is feasible for prevention of HCC.
Lipophilic #Statins and Risk for #Hepatocellular Carcinoma and Death in Patients With Chronic Viral Hepatitis: Results From a Nationwide Swedish Population
https://annals.org/aim/article-abstract/2748619/lipophilic-statins-risk-hepatocellular-carcinoma-death-patients-chronic-viral-hepatitis
..Compared with matched nonusers, 10-year HCC risk was significantly lower among lipophilic statin users (8.1% vs. 3.3%; absolute risk difference [RD], −4.8 percentage points [95% CI, −6.2 to −3.3 percentage points]; adjusted subdistribution hazard ratio [aHR], 0.56 [CI, 0.41 to 0.79]) but not hydrophilic statin users (8.0% vs. 6.8%; RD, −1.2 percentage points [CI, −2.6 to 0.4 percentage points]; aHR, 0.95 [CI, 0.86 to 1.08)..
In a nationwide viral hepatitis cohort, lipophilic statins were associated with significantly reduced HCC incidence and mortality. An association between hydrophilic statins and reduced risk for HCC was not found. Further research is needed to determine whether lipophilic statin therapy is feasible for prevention of HCC.
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#Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database
Among the 3900 patients aged 80 years and older, 2 years of statin prescriptions resulted in a lower risk of the composite outcome (adjusted HR = 0.81; 95% confidence interval [CI] = 0.66‐0.99) and of all‐cause mortality (adjusted HR = 0.84; 95% CI = 0.73‐0.97). During 4.5 years of median follow‐up, the NNT for prevention of the primary outcome was 59; and for mortality, the NNT was 36. Correcting for 36.2% deaths during the first 2 years increased the NNT on the primary outcome to 93 and to 61 on all‐cause mortality.
CONCLUSION
Our data support statin initiation after a first #MI in patients aged 80 years and older if continued for at least 2 years. Especially in patients with a low risk of 2‐year mortality, statins should be considered.
https://onlinelibrary.wiley.com/doi/full/10.1111/jgs.16227
#Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database
Among the 3900 patients aged 80 years and older, 2 years of statin prescriptions resulted in a lower risk of the composite outcome (adjusted HR = 0.81; 95% confidence interval [CI] = 0.66‐0.99) and of all‐cause mortality (adjusted HR = 0.84; 95% CI = 0.73‐0.97). During 4.5 years of median follow‐up, the NNT for prevention of the primary outcome was 59; and for mortality, the NNT was 36. Correcting for 36.2% deaths during the first 2 years increased the NNT on the primary outcome to 93 and to 61 on all‐cause mortality.
CONCLUSION
Our data support statin initiation after a first #MI in patients aged 80 years and older if continued for at least 2 years. Especially in patients with a low risk of 2‐year mortality, statins should be considered.
https://onlinelibrary.wiley.com/doi/full/10.1111/jgs.16227
Wiley Online Library
Statins After Myocardial Infarction in the Oldest: A Cohort Study in the Clinical Practice Research Datalink Database
OBJECTIVE
To explore the effect of initiating statins for secondary prevention after a first myocardial infarction (MI) in patients aged 80 years and older.
DESIGN
Retrospective cohort study.
SE...
To explore the effect of initiating statins for secondary prevention after a first myocardial infarction (MI) in patients aged 80 years and older.
DESIGN
Retrospective cohort study.
SE...
Meta-analysis of Effectiveness of #Statins in Patients with Severe #COVID-19
https://2medical.news/2020/09/02/meta-analysis-of-effectiveness-of-statins-in-patients-with-severe-covid-19/
..Our Pubmed search yielded 274 potential studies. After deduplication and application of the eligibility criteria, four studies with a total of 8,990 COVID-19 patients were included for meta-analysis. Except for Yan et al. which is of moderate quality (5/9), other studies are of good quality (at least 7/9). Study characteristics are provided in Table 1. The pooled analysis revealed a significantly reduced hazard for fatal …
https://2medical.news/2020/09/02/meta-analysis-of-effectiveness-of-statins-in-patients-with-severe-covid-19/
..Our Pubmed search yielded 274 potential studies. After deduplication and application of the eligibility criteria, four studies with a total of 8,990 COVID-19 patients were included for meta-analysis. Except for Yan et al. which is of moderate quality (5/9), other studies are of good quality (at least 7/9). Study characteristics are provided in Table 1. The pooled analysis revealed a significantly reduced hazard for fatal …
Evaluation of Time to Benefit of #Statins for the Primary Prevention of Cardiovascular Events in Adults Aged 50 to 75 Years A Meta-analysis
https://2medical.news/2020/11/20/evaluation-of-time-to-benefit-of-statins-for-the-primary-prevention-of-cardiovascular-events-in-adults-aged-50-to-75-years-a-meta-analysis/
Guidelines recommend targeting preventive interventions toward older adults whose life expectancy is greater than the intervention’s time to benefit (TTB). The TTB for statin therapy is unknown To conduct a survival meta-analysis of randomized clinical trials of statins to determine the TTB for prevention of a first major adverse cardiovascular event (MACE) in adults aged 50 to 75 years.. Eight trials randomizing 65 383 adults (66.3% …
https://2medical.news/2020/11/20/evaluation-of-time-to-benefit-of-statins-for-the-primary-prevention-of-cardiovascular-events-in-adults-aged-50-to-75-years-a-meta-analysis/
Guidelines recommend targeting preventive interventions toward older adults whose life expectancy is greater than the intervention’s time to benefit (TTB). The TTB for statin therapy is unknown To conduct a survival meta-analysis of randomized clinical trials of statins to determine the TTB for prevention of a first major adverse cardiovascular event (MACE) in adults aged 50 to 75 years.. Eight trials randomizing 65 383 adults (66.3% …
Drug-specific and dosage effects of #statins and the risk of #cancer: a population-based cohort study in South Korea
https://2medical.news/2021/02/08/drug-specific-and-dosage-effects-of-statins-and-the-risk-of-cancer-a-population-based-cohort-study-in-south-korea/
This study aimed to investigate whether the drug-specific and dosage effects of statin use were associated with a lower risk of cancer in adults in South Korea. We evaluated the adult population registered in the 2010 sample cohort database of South Korea. Subjects were divided into the statin group (those who had been prescribed continuous oral statin over 1 year) and the control group (those …
https://2medical.news/2021/02/08/drug-specific-and-dosage-effects-of-statins-and-the-risk-of-cancer-a-population-based-cohort-study-in-south-korea/
This study aimed to investigate whether the drug-specific and dosage effects of statin use were associated with a lower risk of cancer in adults in South Korea. We evaluated the adult population registered in the 2010 sample cohort database of South Korea. Subjects were divided into the statin group (those who had been prescribed continuous oral statin over 1 year) and the control group (those …
Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection
https://2medical.news/2021/10/24/association-of-statins-and-28-day-mortality-in-patients-hospitalized-with-sars-cov-2-infection/
https://2medical.news/2021/10/24/association-of-statins-and-28-day-mortality-in-patients-hospitalized-with-sars-cov-2-infection/
2Medical.News
Association of #Statins and 28-Day Mortality in Patients Hospitalized with #SARS CoV-2 Infection
Statins may be protective in SARS-CoV-2 infection. The aim of this study was to evaluate the effect of in-hospital statin use on 28-day mortality and ICU admission among patients with SARS-CoV-2 st…
#Statins and cognitive decline in patients with #Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study
https://2medical.news/2024/01/12/statins-and-cognitive-decline-in-patients-with-alzheimers-and-mixed-dementia-a-longitudinal-registry-based-cohort-study/
https://2medical.news/2024/01/12/statins-and-cognitive-decline-in-patients-with-alzheimers-and-mixed-dementia-a-longitudinal-registry-based-cohort-study/
2Medical.News
#Statins and cognitive decline in patients with #Alzheimer’s and mixed dementia: a longitudinal registry-based cohort study
BackgroundDisturbances in brain cholesterol homeostasis may be involved in the pathogenesis of Alzheimer’s disease (AD). Lipid-lowering medications could interfere with neurodegenerative processes …
#Statins and risks of #dementia among patients with heart failure: a population-based retrospective cohort study in Hong Kong
https://2medical.news/2024/02/03/statins-and-risks-of-dementia-among-patients-with-heart-failure-a-population-based-retrospective-cohort-study-in-hong-kong/
https://2medical.news/2024/02/03/statins-and-risks-of-dementia-among-patients-with-heart-failure-a-population-based-retrospective-cohort-study-in-hong-kong/
2Medical.News
#Statins and risks of #dementia among patients with heart failure: a population-based retrospective cohort study in Hong Kong
Heart failure (HF) and dementia frequently co-exist with shared pathological mechanisms and risk factors. Our study aims to investigate the association between statin therapy and the risks of demen…