مساء الخير يا شباب دلوقتي هنزل ليكم أهم notes على درس neonatal cholestasis
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■ Notes on neonatal cholestasis :-
● cholestasis in infancy is defined as
♤ a direct/ Conjugated bilirubin > 1mg if total is < 5mg /dl
♤ a direct / conjugated bilirubin >20% of the total , if total s.bilirubin was > 5 mg/dl
● The most common metabolic syndrome is alpha 1 antitrpsin deficiency
● the most common treatable causes of cholestasis is BA
● BA is the most common single cause of chronic cholestasis in infants & children
● BA is presented with deep yellow urine , pale colored stool & hepatomegly
● intra-operative cholangiography is goldstandard for diagnosis of BA
● kasai operation ( KPE) is the best choice of surgery for ttt of BA should be performed before 60 days
● Dubin johnson s & rotor s are congenital diseases with direct hyperbilirubinemia with normal liver functions
● AGS is diagnosed by 3 of 5 major criteria are required
● Direct bilirubin can pass urine , while indirect urine does not pass
● Bacterial sepsis should be considered in a sick cholestatic baby with elevated total & direct serum bilirubin & slight or modest elevation of transaminases
● ALP & GGT are elevated in biliary tract obstruction
● TTT of glactosemia is elemental formula AA based )
● should restrict proteins with patients with LCF
● cholestasis in infancy is defined as
♤ a direct/ Conjugated bilirubin > 1mg if total is < 5mg /dl
♤ a direct / conjugated bilirubin >20% of the total , if total s.bilirubin was > 5 mg/dl
● The most common metabolic syndrome is alpha 1 antitrpsin deficiency
● the most common treatable causes of cholestasis is BA
● BA is the most common single cause of chronic cholestasis in infants & children
● BA is presented with deep yellow urine , pale colored stool & hepatomegly
● intra-operative cholangiography is goldstandard for diagnosis of BA
● kasai operation ( KPE) is the best choice of surgery for ttt of BA should be performed before 60 days
● Dubin johnson s & rotor s are congenital diseases with direct hyperbilirubinemia with normal liver functions
● AGS is diagnosed by 3 of 5 major criteria are required
● Direct bilirubin can pass urine , while indirect urine does not pass
● Bacterial sepsis should be considered in a sick cholestatic baby with elevated total & direct serum bilirubin & slight or modest elevation of transaminases
● ALP & GGT are elevated in biliary tract obstruction
● TTT of glactosemia is elemental formula AA based )
● should restrict proteins with patients with LCF
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" Clinical Notes " pinned «■ Notes on neonatal cholestasis :- ● cholestasis in infancy is defined as ♤ a direct/ Conjugated bilirubin > 1mg if total is < 5mg /dl ♤ a direct / conjugated bilirubin >20% of the total , if total s.bilirubin was > 5 mg/dl ● The most common metabolic…»
All the followings are symptoms of wilson disease except ?
Anonymous Quiz
3%
Majority of cases are diagnosed between 5-35 years old
1%
Hepatomegly & splenomegly
43%
Hypocalcemia
3%
Labile mood & irritablity
51%
All of the above are true
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All the following are causes of constipation except ?
Anonymous Quiz
1%
Hirshsprung disease
1%
DM
10%
Hypokalemia
10%
DI ( Diabetes inspidous)
9%
Hyperparathyriodism
69%
Hyperthyroidism
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■ مساء الخير يا شباب ، توضيح بالنسبة للسؤال الأول بتاع symptoms of wilson disease انه cu يزيد بيروح يترسب من ضمن الأماكن Parathyroid فيعمل hypofunction ليها فبالتالي انخفض نسبة PTH فبالتالي يقل Ca فيعمل hypocalcemia
♤ السؤال الثاني ال hyperthyroidism يعني free T3 & T4 عاليين و من ضمن الحاجات ال بتزود intestinal motility فالعيان يدخل ف diarrhea مش constipation .
♤ السؤال الثاني ال hyperthyroidism يعني free T3 & T4 عاليين و من ضمن الحاجات ال بتزود intestinal motility فالعيان يدخل ف diarrhea مش constipation .
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All the followings may be seen in cholestasis, except ?
Anonymous Quiz
82%
Deficiency of Vit B6
8%
Pruritis
4%
Clay-pale coloured stool
6%
Fat malabsorption
Which of the following should be avoided with an infant with galactosemia ?
Anonymous Quiz
78%
Milk
14%
Wheat
4%
Rice
4%
Egg
Cholestasis can diagnosed properly by all the followings except ?
Anonymous Quiz
9%
Liver biopsy
7%
Liver enzymes
79%
Asciatic tap
5%
Abdominal sonar
Cholestasis is not characterized by ?
Anonymous Quiz
14%
Vit E deficiency
74%
Increased sr albumin
6%
Increased total sr bilirubin
6%
Dark colored urine
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What is ur diagnosis in previous case ?
Anonymous Quiz
82%
BA
16%
Neonatal hepatitis
2%
Choledochol cyst
0%
Hypothyroidism
All the followings are true about BA except one ?
Anonymous Quiz
3%
It presents about 25-45 % of NC
4%
It presents with hepatmegly & dark colored urine
1%
It treated by kasai operation
92%
Liver biopsy is the goldstandred to diagnose BA
All of the followings are true about Dubin-Johnson syndrome except ?
Anonymous Quiz
15%
Total sr bilirubin usually ranges from 1.5 - 6 mg/dl
9%
Normal liver function tests
8%
A direct hyperbilirubinemia
68%
Black pigemnt of the kidney is characteristic
One of major criteria are correct in Alagille syndrome ?
Anonymous Quiz
16%
Acute cholestasis
21%
Stenosis of proximal pulmonary artey branch
47%
Deep set eyes
16%
Anterior embryotoxon
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■ Notes on Neonatal cholestasis :
https://t.me/med_Notes2/552
■ MCQ on Neonatal cholestasis :
https://t.me/med_Notes2/560
https://t.me/med_Notes2/552
■ MCQ on Neonatal cholestasis :
https://t.me/med_Notes2/560
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" Clinical Notes "
■ Notes on neonatal cholestasis :-
● cholestasis in infancy is defined as
♤ a direct/ Conjugated bilirubin > 1mg if total is < 5mg /dl
♤ a direct / conjugated bilirubin >20% of the total , if total s.bilirubin was > 5 mg/dl
● The most common metabolic…
● cholestasis in infancy is defined as
♤ a direct/ Conjugated bilirubin > 1mg if total is < 5mg /dl
♤ a direct / conjugated bilirubin >20% of the total , if total s.bilirubin was > 5 mg/dl
● The most common metabolic…
" Clinical Notes "
All the following are causes of constipation except ?
السؤال ده يا جماعة توضيحه :
● مبدئياً hypokalemia قالها الدكتور أسامة في شرحه لموضوع constipation و فعلا هي من ضمن أسباب و من أشهر الأسباب اللي بتعمل و تاني حاجة مكتوبة في الباطنة
● توضيح من زميلنا :
من ال complications of GE ال hypokalemia اللي من ضمنها paralytic illeus فطبيعي جدا تبقى بتعمل constipation ، ال hyperkalemia اللي ممكن تعمل diarrhea أو constipation
● مبدئياً hypokalemia قالها الدكتور أسامة في شرحه لموضوع constipation و فعلا هي من ضمن أسباب و من أشهر الأسباب اللي بتعمل و تاني حاجة مكتوبة في الباطنة
● توضيح من زميلنا :
من ال complications of GE ال hypokalemia اللي من ضمنها paralytic illeus فطبيعي جدا تبقى بتعمل constipation ، ال hyperkalemia اللي ممكن تعمل diarrhea أو constipation
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مساء الخير يا شباب هنزل ليكم أهم ال note على درس Gastroenteritis اللي ممكن يجي منها ف mcq
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