GPAT/NIPER study point
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Discussion of major subjects of GPAT/NIPER
Discussion of pyq of both GPAT /NIPER
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5. What is the primary route of drug elimination in the body?
Anonymous Quiz
5%
A) Lungs
78%
B) Kidneys
11%
C) Skin
6%
D) Saliva
6. Which of the following pharmacokinetic parameters represents the volume of distribution?
Anonymous Quiz
5%
A) Ke
83%
B) Vd
6%
C) Cl
5%
D) AUC
👍3
7. The elimination rate constant (Ke) is calculated using which equation?
Anonymous Quiz
45%
A) Ke = 0.693/t1/2
20%
B) Ke = AUC × Dose
30%
C) Ke = Cl × Vd
5%
D) Ke = Tmax × Cmax
👍3
8. The half-life (t1/2) of a drug is dependent on which of the following?
Anonymous Quiz
5%
A) Drug formulation
16%
B) Route of administration
77%
C) Clearance and volume of distribution
2%
D) Body temperature
👍2
10. Which of the following parameters is used to determine drug clearance (Cl)?
Anonymous Quiz
10%
A) Cl = Ke × AUC
50%
B) Cl = Vd × Ke
26%
C) Cl = AUC / Dose
14%
D) Cl = t1/2 × AUC
👍2
13. Which factor influences the bioavailability of a drug?
Anonymous Quiz
11%
A) Metabolism in the liver
7%
B) Water solubility
5%
C) Drug particle size
76%
D) All of the above
14. Which pharmacokinetic model considers actual physiological processes?
Anonymous Quiz
19%
A) One-compartment model
31%
B) Two-compartment model
45%
C) Physiological model
5%
D) Non-compartment model
15. Which drug administration route avoids first-pass metabolism?
Anonymous Quiz
14%
A) Oral
70%
B) Intravenous
11%
C) Rectal
5%
D) Subcutaneous
👏2
16. Which pharmacokinetic process primarily follows first-order kinetics?
Anonymous Quiz
50%
A) Drug absorption
30%
B) Drug elimination
13%
C) Drug distribution
6%
D) Drug metabolism
👍2
17. What is the primary advantage of intravenous infusion over bolus injection?
Anonymous Quiz
4%
A) Slower drug clearance
39%
B) Higher bioavailability
54%
C) Maintains a steady drug concentration
3%
D) Increased drug metabolism
👍2
19. The area under the curve (AUC) is mainly used to assess which pharmacokinetic property?
Anonymous Quiz
45%
A) Bioavailability
29%
B) Drug elimination rate
11%
C) Drug-protein binding
15%
D) Volume of distribution
👍1
20. Which parameter determines how quickly a drug is removed from the body?
Anonymous Quiz
53%
A) Clearance (Cl)
20%
B) Volume of distribution (Vd)
11%
C) Absorption rate constant (Ka)
15%
D) Half-life (t1/2)
👍1
23. In extravascular drug administration, what determines the absorption rate?
Anonymous Quiz
17%
A) Bioavailability
63%
B) Absorption rate constant (Ka)
16%
C) Volume of distribution
4%
D) Renal clearance
1👍1
24. What is the key factor affecting first-pass metabolism?
Anonymous Quiz
26%
A) Gastric emptying rate
49%
B) Liver enzyme activity
13%
C) Renal clearance
12%
D) Drug solubility
25. Which pharmacokinetic model is commonly used for IV infusion drug administration?
Anonymous Quiz
33%
A) One-compartment model
41%
B) Two-compartment model
20%
C) Physiological model
6%
D) Non-compartmental model