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Rational Use of Medicines Free Course

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"Drugs And their active Metabolite"

1). Rifampicin - Desacetylated metabolite
2).Thioridazine - Mesoridazine
3). Quinidine - 3- hydroxy quinone.
4). propanolol - N- deisopropyl met.
5). Naloxsne - 6 hydroxy Naloxane.
6). Morphine - Nor morphine
7).Guanethidine - N- OXIDE
8). CODEINE - MORPHINE,. Nor Morphine
9). Amytryptylline - Nortryptalline

10).Carbimazole - Thiamazole

"Drug Of Choice"

1. Clonidine withdrawal
👉Phentolamine

2.Primary open angle glaucoma
👉Latanoprost

3. Breast cancer
👉Tamoxifen

4. Endometriosis
👉Danazol

5.Thyroid storm
👉Propylthiouracil

6.Acute Hyperkalemia
👉Calcium Gluconate

7.Severe Digitalis toxicity
👉DIGIBIND

8.Acute migraine
👉Sumatriptan

9.Kala azar
👉Liposomal amphotericin B

10.Iron poisoning
👉Desferrioxamine

11.VRSA
👉Linezolid

12.Alcohol poisoning
👉Fomepizole

13.Diabetic ketoacidosis
👉IVF

"TABLETS AND CAPSULES MACHINE"

1. Rotosort:-
👉 for filled / unfilled capsule sorting machine and for de-dusting.

2. Rotofill:-
👉 to fill pellets in hard gelatin capsule

3. Rotoweigh:-
👉 A high speed capsule weighing machine.

4. Accogel:-
👉 filling of dry powder in soft gelatin capsule.

5. Accofill:-
👉fill exact powder dose in hard gelatin capsule

6. Wurster:-
👉for coating.

7. Osaka:-
👉capsule filling machine (powder, granules)

8. Zanasi:-
👉 filling (powder, pellets, tablets)

9. Lily / parke-davis :-
👉 capsule filling (powder)

10. Farmatic, holfiger & kary-liquid filling in HGC .

11. Erweka:-
👉 De-dusting and polishing capsule machine.

12. Seidender :-
👉Uses a Belt for visual inspection.

13. Vericap 1200:-
👉capsule weighing machine.

01. Immunoglobulin is? (2 light, 2 heavy, disulfide)
02. Which of following not causing enzyme induction? (Sulfonamide)
03. Detector used in IR? (Thermocouple)
04. Function of microvilli is? (Increase surface area)
05. pH of 0.005M HCL?
06. pH of pKa 5.4 is?
07. IR range of CO (acid chloride)
08. Neostigmin does not cross BBB? (Polar)
09. Drugs which cross BBB are? (lipophilic drugs)
10. Which is most commonly used HPLC? (Reverse Phase)
11. Phenolphthalein is? (Acid base indicator)
12. Drug assayed by acid-base back titration? (Aspirin)
13. Which of following is titrated using strong base? (Refer IP for titrations,
this can be considered as important)
14. Amiloride and Spiranolactone differs in?
15. Statin mechanism? (Reduce cholesterol)
16. Which of following is not related with enalapril (It is not an AT1
antagonist)
17. Equation of Angle of Repose.
18. Character of liposome is?
19. Eye drops and parentral differ in?
20. Colchicines is used in Gout.
______

1. Which is cytotoxic from following marine? (bryostatin)
2. To avoid crystallization of syrup which substance is added? (polyhydric alcohols)
3. Particle size of fluid energy mill is? (1-30micrometer)
4. Use of Gallic acid? (Antioxidant)
5. HLB of o/w emulsion. (3-8)
6. Range of Visible light? (400-800nm options were in micro so read questions carefully
before attaining )
7. Source of IR (Nerst glower)
8. Hydrogen bonding determined by which method? (Raman)
9. Most intense peak in MASS spectra? (Base peak)
10. How to determine non-UV active structure? (derivatization)
11. Energy comparison of UV, IR n NMR. Means put them in ascending order of their energies.
(NMR least<IR<UV highest)
12. Reference standard used in NMR? (TMS)
13. In IR calibration which substance is used? (Air)
14. What does RS means in IP? (Reference standard)
15. Sparingly soluble? (30 to 100 parts)
16. Cough is S/E of? (captopril)
17. Capsule '000' size capacity?
18. Green bones are made up of which type of gelatin? (type B)
19. Vehicle used in SGC?
20. Which property not related to polymorphism? (chemical assay)
21. Ostwald ripening is related with? (suspension)
22. Osmotic pressure of blood is?
23. Duration of nasal delivery
24. Duration of mucoadhesive delivery
25. Largest cotton producing country
26. Free trade port in India? (Kandla)
27. Amoebiasis is caused by? (E.histolytica)
28. In clock 12'o clock is north east then at 1:30pm what would be direction? (East)
29. In monosubstituted cyclohexane which structure will be stable?
30. Stereochemistry of Alanine
31. Linkage in amylase
32. Teratogenic vitamin? (A)
33. In cyclic carbohydrates stereochemistry is known as? (anomer)
34. Propranolol is contraindicated in? (Asthma)
35. Highest first pass metabolism of following?
a. propranolol (ans) b. digoxin c. Phenobarbital d. phenytoin
36. Which of this is cardiotoxic (Adriamycin)
37. M/A of paclitaxol is?
38. Therapeutic index denotes (Margin of safety)
39. Selective ï ¡ 1 blocker is? (Prazosin)
40. Activity of receptor (drug selectivity and selective antagonist action of drug)
41. Receptors are made up of? (protein)
42. Cytokinins are?
43. Morphine act through ï receptor.
44. Nicotinic receptor work through which messenger system?
45. Example of Neurodegenerative disorder. (Alzheimer's Disease)
46. Action of Ach? (Hastens G.I. emptying)
47. Name of Indian Ginseng? (Withania Somnifera)
48. Father of Chemotherapy? (Paul Ehrlich)
49. Out of following which is not containing bacteria?
a. Soil b. Ice c. Dust d. Blood (ans) (blood is sterile unless infected)
50. Drug approved by US FDA for alopecia? (Minoxidil)