The pKa of the mepivacaine is 8.7. If the pH of the infected tissue is 9.7, the fraction of the drug in the ionized form will be
Anonymous Quiz
16%
1 %
48%
10 %
31%
90 %
6%
99 %
GPAT/NIPER study point
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Which of the following drugs causes less inhibition or REM sleep[GPAT - 2016]
Anonymous Quiz
39%
Zolpidem
22%
Ethanol
28%
Lorazepam
12%
Phenobarbitone
Target receptor of bicuculline is [NIPER JEE 2020]
Anonymous Quiz
35%
GABAA
31%
NMDA receptors
26%
Glutamate receptors
8%
Nicotinic receptors
Which one of the following is a competitive antagonist at benzodiazepine site of GABA-receptor gated chloride channel [GPAT 2021]
Anonymous Quiz
13%
Muscimol
49%
Flumazenil
16%
Picrotoxin
22%
Beta-carboline (DMCM)
Inverse agonist of benzodiazepine receptor is:
Anonymous Quiz
28%
Flumazenil
33%
Phenobarbitone
19%
Gabapentin
20%
Beta carboline
Duration of action of flumazenil is:
Anonymous Quiz
19%
5 minute
54%
30 minute
21%
10 minute
6%
20 minute
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GABA -mimetic action shown by
Anonymous Quiz
31%
Barbiturates
55%
Benzodiazepines (BZD)
8%
Flumezenil
7%
Baclofen
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SEDATIVE & HYPNOTIC DRUGS .pdf
What is mechanism of action of carbamazepine [GPAT 2015]
Anonymous Quiz
37%
Inhibition of GABA transaminase
31%
Blockade of sodium channel
17%
Blockade of glutamate receptor
15%
Blockade of GABA receptors
Irreversible inhibitor of GABA aminotransferase (GABA-T)
Anonymous Quiz
23%
Diazepam
38%
Phenobarbital
15%
Felbamate
24%
Vigabatrin
Vigabatrin produces anti-epileptic activity through (GPAT - 2021)
Anonymous Quiz
22%
Potentiating GABA mediated neuronal inhibition by depressing GABA transporters
26%
Modifying synaptic release of glutamate/GABA by binding to a specific synaptic protein
48%
Inhibiting GABA transaminase enzyme which degrades GABA
4%
Potentiating post synaptic GAGA receptor effect
GPAT 2019: Which of the following anticonvulsants have both inhibition of excitatory glutamatergic synapse and facilitation of GABA mediated Cl channel opening action
Anonymous Quiz
34%
Valproate
34%
Ethosuximide
15%
Topiramate
16%
Phenytoin
Valproate and carbamazepine can be used as first line drugs for management of following type of seizures. [GPAT 2023]
Anonymous Quiz
40%
Both partial and tonic clinic seizure
44%
Both tonic clonic and status epilepticus
10%
Only febrile seizure
6%
Both febrile and status epilepticus
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Which of the following is Endogenous antiepileptic subststance?
Anonymous Quiz
13%
Adenine
26%
Thymine
42%
Adenosine
19%
Glycine