----RA---
RF not specific,
ACCP 98%specific مهم
--JIA--
Rf usual
postive with polyarthritis
20% uevitis ANA postive mostly with oligoarthritis less than 5 joint
Seronegative dis all RF negative
Usual assocciated with HLA -B27
1-Ankalosing spondylitis
assocciated with
HLA -B27 positve 90%
لكن ايضا نحتاج لclinical feature
2-Reactive arthritis
assocciated or not with
HLA B27
Clinical: diarrhea( infection) ,STD
arthritis
If arthritis+ conjuctvitis , urethritis become Reiter syndrome
3-entropathic arthritis
assocciated with inflammtory bowel dis
(chron, ulcerative colitis)
4-psoriatic arthritis
assocciated with
envionmental(psoriasis and steptopharyngial ) and gentic factor ( HLA -B27,38 ,39,57)
diagnosis clinical by Caspar. C
*
SLA
ANA senstive 95%
AdsDNA specific95%
A smooth muscle A most specif
anti-Ro (neonatal )
⬇️C3,C4
****
Drug induce Lupus- antihiston A
Normal C3,C4
****
Antiphosphlipid syndrome
ANA not specific
anticarodiolipin -specific
Lupus anticoagulant-specific
B2 globulin
***
Scleroderma (systemic sclrosis)
ANA not specific
DCSS --ant Scl-70 A
LCSS(CREST)_anticenteromere
Skin biopsy ..
**
Sjogren syndrome
ANA , RF -- Not specific
Anti_RO
Anti- La antibody -specific
diagnosis by lip biopsy
****
Polymyositis --muscle biopsy
dermatomyositis--
Gottron papules pathgnmonics.
Muscle biopsy
*
Behcet syndrome
assocciated with HLA 51
Pthargy test
**
Vasculitis
RF ,ANA-- NOT specific
ANCA -- very important
*ANCA -C ,PR3 -wegener dis
ANCA- P Churg-Strauss s
Negative ANCA _ microscopic p
RF not specific,
ACCP 98%specific مهم
--JIA--
Rf usual
postive with polyarthritis
20% uevitis ANA postive mostly with oligoarthritis less than 5 joint
Seronegative dis all RF negative
Usual assocciated with HLA -B27
1-Ankalosing spondylitis
assocciated with
HLA -B27 positve 90%
لكن ايضا نحتاج لclinical feature
2-Reactive arthritis
assocciated or not with
HLA B27
Clinical: diarrhea( infection) ,STD
arthritis
If arthritis+ conjuctvitis , urethritis become Reiter syndrome
3-entropathic arthritis
assocciated with inflammtory bowel dis
(chron, ulcerative colitis)
4-psoriatic arthritis
assocciated with
envionmental(psoriasis and steptopharyngial ) and gentic factor ( HLA -B27,38 ,39,57)
diagnosis clinical by Caspar. C
*
SLA
ANA senstive 95%
AdsDNA specific95%
A smooth muscle A most specif
anti-Ro (neonatal )
⬇️C3,C4
****
Drug induce Lupus- antihiston A
Normal C3,C4
****
Antiphosphlipid syndrome
ANA not specific
anticarodiolipin -specific
Lupus anticoagulant-specific
B2 globulin
***
Scleroderma (systemic sclrosis)
ANA not specific
DCSS --ant Scl-70 A
LCSS(CREST)_anticenteromere
Skin biopsy ..
**
Sjogren syndrome
ANA , RF -- Not specific
Anti_RO
Anti- La antibody -specific
diagnosis by lip biopsy
****
Polymyositis --muscle biopsy
dermatomyositis--
Gottron papules pathgnmonics.
Muscle biopsy
*
Behcet syndrome
assocciated with HLA 51
Pthargy test
**
Vasculitis
RF ,ANA-- NOT specific
ANCA -- very important
*ANCA -C ,PR3 -wegener dis
ANCA- P Churg-Strauss s
Negative ANCA _ microscopic p
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Pregnant (Amoxicillin, Augmentin, Cephalexin, Nitrofurantoin,
Cefuroxime, Cefpodoxime, TMP/SMX category C)
علاج الcystitis وهمين للي عدهم G6PD
AACCC+N
Cefuroxime, Cefpodoxime, TMP/SMX category C)
علاج الcystitis وهمين للي عدهم G6PD
AACCC+N