✳️ Prevalence and Prognosis of Mild Inflammatory Bowel Disease: A Population-based Cohort Study, 1997–2020.
▶️ Conclusions : Approximately one-fourth of individuals with mild UC within 1 year after diagnosis and one-half of those with mild CD progressed to moderate-severe disease over time. Young age at diagnosis increased the probability of progression, whereas increasing duration of mild disease decreased the probability.
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▶️ Conclusions : Approximately one-fourth of individuals with mild UC within 1 year after diagnosis and one-half of those with mild CD progressed to moderate-severe disease over time. Young age at diagnosis increased the probability of progression, whereas increasing duration of mild disease decreased the probability.
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CGH December 2025
✳️ Effect of glucagon-like peptide-1 receptor agonists on histologic MASH: A meta-analysis of randomized controlled trials.
▶️ Conclusions:
In patients with noncirrhotic MASH, GLP-1RAs appear to be associated with both MASH resolution without fibrosis worsening and ≥1-stage fibrosis regression without MASH worsening.
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▶️ Conclusions:
In patients with noncirrhotic MASH, GLP-1RAs appear to be associated with both MASH resolution without fibrosis worsening and ≥1-stage fibrosis regression without MASH worsening.
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AASLD February 2026
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✳️ Clinically significant portal hypertension (CSPH) can be diagnosed without elastography by identifying gastroesophageal varices on endoscopy, portosystemic collaterals or hepatofugal flow on imaging, or clinical decompensation (ascites, variceal bleeding). These findings are sufficient to establish the diagnosis of CSPH, which is defined as hepatic venous pressure gradient (HVPG) ≥10 mm Hg.
▶️ Conventional imaging modalities including ultrasound, CT, and MRI can identify surrogate markers of CSPH such as portosystemic collaterals (periesophageal varices, recanalized umbilical vein, splenorenal shunt), dilated portal vein (>12 mm), splenomegaly (≥13 cm), and ascites. Doppler ultrasound demonstrating hepatofugal flow within the portal system is also considered adequate to diagnose CSPH.
▶️ Thrombocytopenia , platelet count alone has insufficient accuracy to exclude CSPH and cannot eliminate the need for endoscopic assessment to detect varices requiring treatment.
▶️ Blood-based scores such as APRI and FIB-4 have limited diagnostic accuracy for CSPH, with sensitivities of 56% and 54% and specificities of 68% and 73%, respectively. The liver stiffness-spleen size-to-platelet ratio (values >2.65 corresponding to >80% risk of CSPH) has shown promise but requires further validation.
▶️ In the absence of elastography, combining clinical findings, laboratory markers (particularly platelet count), and imaging evidence provides the best available approach to assess for CSPH, though many patients will remain in a diagnostic "gray zone" requiring further evaluation.
▶️ Conventional imaging modalities including ultrasound, CT, and MRI can identify surrogate markers of CSPH such as portosystemic collaterals (periesophageal varices, recanalized umbilical vein, splenorenal shunt), dilated portal vein (>12 mm), splenomegaly (≥13 cm), and ascites. Doppler ultrasound demonstrating hepatofugal flow within the portal system is also considered adequate to diagnose CSPH.
▶️ Thrombocytopenia , platelet count alone has insufficient accuracy to exclude CSPH and cannot eliminate the need for endoscopic assessment to detect varices requiring treatment.
▶️ Blood-based scores such as APRI and FIB-4 have limited diagnostic accuracy for CSPH, with sensitivities of 56% and 54% and specificities of 68% and 73%, respectively. The liver stiffness-spleen size-to-platelet ratio (values >2.65 corresponding to >80% risk of CSPH) has shown promise but requires further validation.
▶️ In the absence of elastography, combining clinical findings, laboratory markers (particularly platelet count), and imaging evidence provides the best available approach to assess for CSPH, though many patients will remain in a diagnostic "gray zone" requiring further evaluation.
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Barrett s Esophagus- J of Gastro and Hepatol - 2025.pdf
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REVIEW ARTICLE -Barrett's Esophagus
Journal of Gastroenterology and Hepatology November 2025
Target Trial Emulation of Beta‐Blockers After Diagnosis ofColorectal Polyps—Beneficial in Women 2025
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✳️Associations between demographic, clinical and dietary factors and flares in inflammatory bowel disease: the PRognostic effect of Environmental factors in Crohn’s and Colitis (PREdiCCt) prospective cohort study
▶️ Conclusion: Higher habitual meat intake was associated with increased risk of objective flare in UC, suggesting diet may contribute to flare susceptibility in specific patient groups.
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▶️ Conclusion: Higher habitual meat intake was associated with increased risk of objective flare in UC, suggesting diet may contribute to flare susceptibility in specific patient groups.
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BMJ Jan 2025
Acute-on-chronic liver failure (ACLF): pathophysiological mechanisms and clinical management.
Nature 2025
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✳️ The Top Five Recommendations Physicians and Patients Should question include:
▶️ Don't order serum ammonia to diagnose or manage hepatic encephalopathy (HE).
▶️ Don't routinely transfuse fresh frozen plasma, vitamin K, or platelets to reverse abnormal tests of coagulation in patients with cirrhosis prior to abdominal paracentesis, endoscopic variceal band ligation, or any other minor invasive procedures.
▶️ Don't order HFE genotyping based on serum ferritin values alone to diagnose hereditary hemochromatosis.
▶️ Don't perform computed tomography (CT) or magnetic resonance imaging (MRI) routinely to monitor benign focal liver lesions.
▶️ Don't repeat hepatitis C viral load testing in an individual who has established chronic infection, outside of anti- viral treatment.
▶️ Don't order serum ammonia to diagnose or manage hepatic encephalopathy (HE).
▶️ Don't routinely transfuse fresh frozen plasma, vitamin K, or platelets to reverse abnormal tests of coagulation in patients with cirrhosis prior to abdominal paracentesis, endoscopic variceal band ligation, or any other minor invasive procedures.
▶️ Don't order HFE genotyping based on serum ferritin values alone to diagnose hereditary hemochromatosis.
▶️ Don't perform computed tomography (CT) or magnetic resonance imaging (MRI) routinely to monitor benign focal liver lesions.
▶️ Don't repeat hepatitis C viral load testing in an individual who has established chronic infection, outside of anti- viral treatment.
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