Easy module 3rd year

1. Cyclosporine and Tacrolimus primarily work by inhibiting:
A) mTOR protein
B) Phosphatase activity (Calcineurin)
C) IMP Dehydrogenase
D) CD 52 markers

2. Which intracellular protein does Tacrolimus bind to?
A) CD3
B) FKBP
C) CD 80
D) Purine receptors

3. What is the main downstream effect of inhibiting Calcineurin?
A) Increase in IL-2 production
B) Inhibition of IL-2 production
C) Direct lysis of B-cells
D) Stimulation of the cell cycle

4. According to your notes, the primary side effects of Cyclosporine are:
A) Hypotension and Anemia
B) HTN (Hypertension) and Nephrotoxicity
C) GIT upset and Pain
D) Neutropenia and Cell arrest

5. Everolimus and Sirolimus are classified as:
A) Calcineurin inhibitors
B) Cytotoxic agents
C) Antiproliferative (mTOR inhibitors)
D) Monoclonal antibodies

6. The mechanism of Sirolimus involves stopping the:
A) Phosphatase activity
B) Purine synthesis
C) Cell cycle (via mTOR)
D) CD 80-86 interaction

7. Mycophenolate exerts its effect by inhibiting which enzyme?
A) Calcineurin
B) IMP Dehydrogenase
C) mTOR
D) Phosphatase

8. Inhibition of IMP Dehydrogenase by Mycophenolate leads to the inhibition of:
A) Pyrimidines
B) Purines
C) IL-2 receptors
D) CD3 proteins

9. Which of the following is a common side effect of Mycophenolate?
A) Hypertension
B) GIT upset (N, V, D) and Pain
C) Nephrotoxicity
D) Weight gain

10. Azathioprine is specifically labeled in your notes as a:
A) Monoclonal Antibody
B) Calcineurin inhibitor
C) Cytotoxic agent
D) mTOR inhibitor

11. The final result of Azathioprine administration is:
A) Increase in T-cells
B) Cell arrest and No T or B cells
C) Activation of Macrophages
D) Lysis of CD 52

12. Azathioprine and Mycophenolate share which side effects?
A) HTN and Nephrotoxicity
B) Neutropenia and Anemia
C) Direct CD3 inhibition
D) mTOR activation

13. "Same A/E (Adverse Effects) as Mycophenolate" refers to which drug in your notes?
A) Tacrolimus
B) Azathioprine
C) Basiliximab
D) Sirolimus

14. Which MAB targets the CD 80-86 costimulatory signals?
A) Alemtuzumab
B) Muromonab
C) Abatacept (Belatacept)
D) Daclizumab

15. The primary result of Abatacept (Belatacept) action is:
A) Lysis of Macrophages
B) No T-cell activation
C) Inhibition of IMP Dehydrogenase
D) Nephrotoxicity

16. Alemtuzumab works by causing the lysis of:
A) CD3 only
B) CD 80-86
C) CD 52
D) IL-2 receptors

17. Alemtuzumab affects which of the following cell types?
A) T-cells only
B) T-cells, B-cells, and Macrophages
C) Red blood cells
D) Only Macrophages

18. Muromonab specifically targets which protein marker?
A) CD 52
B) CD3
C) CD 80
D) FKBP

19. Which combination of drugs acts as "Anti-IL2"?
A) Cyclosporine and Tacrolimus
B) Basiliximab and Daclizumab
C) Everolimus and Sirolimus
D) Mycophenolate and Azathioprine

20. According to your notes, Basiliximab and Daclizumab belong to the category of:
A) Cytotoxic agents
B) mTOR inhibitors
C) Monoclonal Antibodies (MAB)
D) Calcineurin inhibitors

Answer Key
* B | 2. B | 3. B | 4. B | 5. C | 6. C | 7. B | 8. B | 9. B | 10. C | 11. B | 12. B | 13. B | 14. C | 15. B | 16. C | 17. B | 18. B | 19. B | 20. C

🔥4❤3

670 views18:34