A large portion of all autism cases are due to or aggravated by de novo mutations—mutations harbored by the child, but neither of the parents.
This estimate, for example, was that ~35% of all autism cases and ~60% of all cases in low-risk families were due to de novo variants.
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This estimate, for example, was that ~35% of all autism cases and ~60% of all cases in low-risk families were due to de novo variants.
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JUST IN: Billionaire Mark Cuban says he sold "most" of his Bitcoin.
"Bitcoin has lost the plot."
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"Bitcoin has lost the plot."
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BREAKING: A final draft of a US-Iran agreement has been reached, per Iran's Al Arabiya.
The terms:
• An immediate ceasefire
• Free passage through the Strait of Hormuz
• Sanctions on Iran lifted gradually
• Talks on remaining issues to follow
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The terms:
• An immediate ceasefire
• Free passage through the Strait of Hormuz
• Sanctions on Iran lifted gradually
• Talks on remaining issues to follow
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I suspect math will be like Chess and Go due to verifiability. The period of fruitful collaboration between humans and AI will be short (i.e. a few years or less, not a decade). Progress in math will be jagged, with harder to formalize fields coming last, but I suspect this jaggedness will be compressed in time -- I expect superhuman performance at (nearly?) all areas of math within a few years (a few = 2-3?).
AIs will also be better at asking pure math questions than humans, and will quickly develop theories beyond human comprehension.
Human theorists will have a recreational comparative advantage over other humans in understanding these theories, but AIs will be better at communicating these theories to applied researchers. Pure mathematicians will need to become applied researchers to do productive work, until applied research is also automated.
Confidence level for prediction: 50-65% for gist, 40-50% for all above claims being correct.
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AIs will also be better at asking pure math questions than humans, and will quickly develop theories beyond human comprehension.
Human theorists will have a recreational comparative advantage over other humans in understanding these theories, but AIs will be better at communicating these theories to applied researchers. Pure mathematicians will need to become applied researchers to do productive work, until applied research is also automated.
Confidence level for prediction: 50-65% for gist, 40-50% for all above claims being correct.
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Fascinating hypothesis:
The rise of generative AI/LLMs might not be the reason for the decline in junior-level hiring. Rather, the decline is due to the concomitant rise of work-from-home.
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The rise of generative AI/LLMs might not be the reason for the decline in junior-level hiring. Rather, the decline is due to the concomitant rise of work-from-home.
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BREAKING: US oil prices erase gains and turn red on the day on reports that the US and Iran are finalizing an agreement
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A leftist student at Utah Valley University is sparking mass outrage after recording a video of herself dancing at the site of Charlie Kirk’s assassination.
Contact the university and ask what they plan to do about this.
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Contact the university and ask what they plan to do about this.
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Evidence Exonerating "Chud the Builder" discovered: (by friend of family)
Screenshots showing premeditation by Joshua Luvv to fight Dalton to launch his "twitch streaming."
Joshua Fox / Joshua Luvv Facebook comments from Jan 10, 2026 (18 weeks before the Eatherly incident)
• Fox: "I been hopping to run into the chud mf but he don't be on this side of town. But outside of him ima call them a b&tch and go about my day "
• Kudo Menace (responding): "chud just trolling us for a reaction. Don't let him bother you either. I don't think he's really racist anyway. Just click bait."
• Fox: "trying to get some traction on my end so when I start my twitch I got a little fan base "
• Fox: "oh he don't bother me I just wanna fight "
• Bishop Reemo Yeezy: "on the internet correct. In person? Neutralizing the threat" (followed by a "NO PROBLEM…" meme image)
What this establishes:
• Fox publicly stated his intent to physically seek out "the chud" months before the incident
• Even his own friend characterized the target as "just click bait" and "not really racist"
• Fox's stated motivation was Twitch traction and a fan base, not a response to any actual harm
• Fox explicitly said "I just wanna fight"
• This is documented premeditation. The encounter at the Montgomery County Courthouse was not a chance escalation. It was the outcome Fox had been openly telling people he wanted.
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Screenshots showing premeditation by Joshua Luvv to fight Dalton to launch his "twitch streaming."
Joshua Fox / Joshua Luvv Facebook comments from Jan 10, 2026 (18 weeks before the Eatherly incident)
• Fox: "I been hopping to run into the chud mf but he don't be on this side of town. But outside of him ima call them a b&tch and go about my day "
• Kudo Menace (responding): "chud just trolling us for a reaction. Don't let him bother you either. I don't think he's really racist anyway. Just click bait."
• Fox: "trying to get some traction on my end so when I start my twitch I got a little fan base "
• Fox: "oh he don't bother me I just wanna fight "
• Bishop Reemo Yeezy: "on the internet correct. In person? Neutralizing the threat" (followed by a "NO PROBLEM…" meme image)
What this establishes:
• Fox publicly stated his intent to physically seek out "the chud" months before the incident
• Even his own friend characterized the target as "just click bait" and "not really racist"
• Fox's stated motivation was Twitch traction and a fan base, not a response to any actual harm
• Fox explicitly said "I just wanna fight"
• This is documented premeditation. The encounter at the Montgomery County Courthouse was not a chance escalation. It was the outcome Fox had been openly telling people he wanted.
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NASA has released new renderings of a future lunar base designed to support astronauts living and working on the Moon during long-term science missions under the Artemis program.
The planned habitat would act as a central hub for both crewed and robotic exploration, helping scientists study the Moon and prepare for future missions to Mars. The reveal is an early preview of a larger NASA announcement expected later this month.
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The planned habitat would act as a central hub for both crewed and robotic exploration, helping scientists study the Moon and prepare for future missions to Mars. The reveal is an early preview of a larger NASA announcement expected later this month.
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A police cruiser was left dangling off the edge of the Chesapeake Bay Bridge-Tunnel in Cape Charles, Virginia after crashing Wednesday and flipping over the guardrail. The officer escaped without serious injuries
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A semi-truck traveling on Interstate 15 from California toward Las Vegas overturned after strong winds from a dust storm tipped it onto its side
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As severe thunderstorms pounded New York City on Wednesday, water poured into a Brooklyn subway station, flooding the stairways
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