Incredible mask-off moment

British MP Alex Wilkinson says that X is a "major problem" because you can voice immigration concerns online

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FLASHBACK: Organizing my old files. My Grandfather saved everything. He was a B-25 pilot during WWII in the Pacific theater. His radioman was Charleston Heston. We lost him a few years ago, he was 98

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For decades, many scientists assumed that serial cloning — the repeated cloning of clones — could theoretically continue indefinitely. A landmark 20-year experiment has now demonstrated that this is not the case. Researchers found that successive rounds of somatic cell nuclear transfer lead to the progressive accumulation of genetic mutations, eventually creating insurmountable barriers to further cloning.

The study, conducted by Teruhiko Wakayama and colleagues at the University of Yamanashi in Japan, began in 2005 using cells from a single female mouse. Over nearly two decades, the team produced more than 1,200 cloned mice across 58 generations. Early generations appeared healthy, with cloning success rates even improving slightly in the first 25–26 rounds. However, from around the 27th generation onward, success rates began to decline steadily. By the 57th generation, the average success rate had fallen to just 0.6%. All mice from the 58th generation died within a day of birth due to severe genomic instability.

Whole-genome sequencing revealed that each round of cloning introduced new mutations at a rate approximately three times higher than in naturally mated mice. These included an accumulation of single-nucleotide variants and large structural abnormalities, such as chromosomal losses and translocations. Unlike sexual reproduction, which benefits from natural DNA repair and recombination mechanisms during meiosis, cloning bypasses these processes, allowing deleterious mutations to build up unchecked — akin to the progressive degradation seen in repeated photocopying.

Importantly, while the late-generation cloned mice still appeared phenotypically normal and had typical lifespans up to the 57th generation, the accumulated genetic load proved fatal when attempting the 58th round. The study underscores that, without the introduction of genetic diversity through sexual reproduction, long-term serial cloning in mammals is ultimately unsustainable.

These findings have significant implications for biotechnology. They highlight fundamental limits for applications such as de-extinction efforts, long-term agricultural cloning, and conservation breeding programs. While cloning remains a powerful tool for producing genetically identical animals, the research serves as a clear reminder that current techniques cannot indefinitely replace the evolutionary safeguards provided by sexual reproduction.

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Slavery was a pretty universal practice

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Neat:

Another PSM study found lower risk of Alzheimer's with versus without statins.

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BREAKING: The Italian Navy is considering Turkish TB3 drones after their strong performance during NATO’s Steadfast exercise in the Baltic Sea.

Italy’s aircraft carrier Cavour is structurally similar to Turkey’s TCG Anadolu, making integration relatively straightforward.

Analysts say growing defense ties reflect a shifting relationship between Italy and Turkey.

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DEVELOPING: White people who are moving into South Central Los Angeles has been getting filmed by locals due them having a hard time believing that the one of the most urban parts of America is now being.’gentrified’ for decades South Central has been dominated by the Black and Hispanic community,

I lived in South Central for a summer in 2017, that place is so different from the rest of the U.S. that spotting a White woman with a baby stroller is news.

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DEVELOPING: The police who are tasked at watching over the Haulover Florida Nude Beach were spotted looking visibly uncomfortable with their task

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BREAKING: El Salvador President Bukele destroyed the nation’s anti-Christian monuments and turned them into manhole covers

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JUST IN: Humans across the internet have been left speechless after learning just how complex and detailed computer chips are, this footage displays the engineering under a microscope, ‘it is the closest thing to alien nobody is aware of.’

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These are some of the most evil people around

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BREAKING: John Thune is REFUSING to call back the Senate from their 2 week vacation in order to get DHS funded, saying it’d just be a “show vote”

No, the show vote was you passing a bad bill at 3am just so you could go home.

GET BACK TO DC AND WORK!

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JUST IN - Thousands of paratroopers from the U.S. Army's 82nd Airborne Division arrive in the Middle East — Reuters

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Never let them tell you Japan needs immigrants

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NEW: claudeai ANNOUNCES “COMPUTER USE IS NOW IN CLAUDE CODE” - “CLAUDE CAN OPEN YOUR APPS, CLICK THROUGH YOUR UI, AND TEST WHAT IT BUILT, RIGHT FROM THE CLI”

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Every morning in 2026

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When you tell her you’re a “macro strategist focused on asymmetric risk” instead of a “degenerate gambler”

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BREAKING: The President of Syria has said he is willing to cooperate with the mass repatriation of Syrian refugees from Germany and Europe

It is time for them to go home.

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