Scientists found an off-switch for high cholesterol – and it could save millions of lives.

In a major breakthrough, researchers at the University of Texas at Arlington have uncovered what could be the body’s “off switch” for managing cholesterol during inflammation—potentially opening the door to new treatments for heart disease, diabetes, and even cancer.

The key lies in an enzyme called IDO1, which activates during inflammation. Under normal conditions, immune cells called macrophages help absorb cholesterol. But when inflammation kicks in – from stress, infection, or injury – IDO1 throws a wrench in the system. It triggers the production of a chemical called kynurenine, which stops macrophages from doing their job. Cholesterol builds up. Arteries clog. Disease follows.

When scientists blocked IDO1 in lab settings, those cells regained their cholesterol-regulating ability—suggesting it may be possible to halt disease progression before it begins.

The study didn’t stop there. Scientists also identified another enzyme, nitric oxide synthase (NOS), which worsens IDO1’s effects. Targeting both IDO1 and NOS together could lead to powerful new therapies aimed at preventing inflammation-related illnesses at their source. With cardiovascular disease and diabetes among the world’s leading killers, this discovery could mark a turning point in how we treat—and even prevent—some of the deadliest modern conditions.

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The Israeli military confirmed the elimination of Esmaeil Khatib in Tehran

Khatib was appointed to the post in 2021 by Ali Khamenei after holding several key positions within the Islamic Revolutionary Guard Corps.

He headed the Ministry of Intelligence of Iran, the regime’s central intelligence body and one of its primary instruments of repression.

Khatib played a significant role in directing arrests and killings of demonstrators during recent internal protests in Iran, including the Mahsa Amini protests in 2022–2023.

He also oversaw the ministry’s operations targeting Israeli and American interests worldwide, including within Israeli territory during Operation “Roaring Lion.”

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Is the answer to the toxic food supply a return to local food networks and "household gardening" methods" still practised by millions of people in the former Soviet Union?

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F&Ck Lumumba. Free Etienne Davignon

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In the classroom, IQ is correlated with disruptiveness, and boys are more disruptive than girls; so, high-IQ boys are about as disruptive as average girls

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BREAKING:

The Norwegian Prosecutor's Office has requested more than 7 years in prison for Marius Borg Høiby.

Norwegian Crown Princess Mette-Marit’s son is on trial for multiple counts of rape, domestic violence, assault and possession of 3.5 kg (7.7 pounds) of marijuana

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2004 mfs realizing they're turning 22 this year

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Luxembourg is the world’s first nation to offer free public transport for all, tackling traffic and climate change in one bold move.

Luxembourg has pioneered a bold new era in urban mobility by becoming the first nation on Earth to eliminate fares across its entire public transport network. This groundbreaking policy covers every bus, tram, and train route nationwide, offering free rides to residents, cross-border commuters, and visitors alike.

Financed through general taxation rather than ticket sales, the initiative was designed to tackle the country's severe traffic congestion—once among the worst in Europe per capita—and to sharply cut carbon emissions from road transport. By removing the cost and hassle of tickets, Luxembourg effectively turned public transit into a basic public service, as essential and accessible as clean water or electricity.

The impact has been profound and measurable. Ridership surged as people left their cars behind, leading to noticeably less road traffic, shorter commute times, and a meaningful drop in urban air pollution. While first-class rail options remain a paid upgrade for those wanting extra comfort, the standard second-class system is now truly seamless: hop on, hop off, no barriers.

Luxembourg's experiment has demonstrated that removing financial obstacles can drive a genuine shift toward sustainable travel habits. It has also served as an inspiring model for other countries and cities grappling with sprawl, gridlock, and climate goals. In an age when radical solutions are needed to address the mobility-climate crisis, Luxembourg proves that treating public transport as a universal right is not only feasible—it can be genuinely transformative.

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NEW - Fires rage at the world's largest natural gas field South Pars, Iran, struck by Israeli-American forces, multiple phases of processing capacity critically hit and taken offline

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