Cracks in the US private credit market are intensifying:
Blue Owl Capital shares dropped -22.7% in February, posting their worst month on record.
This marks the 7th consecutive monthly decline, the longest streak in history.
Meanwhile, short interest in Blue Owl is up to 14.7%, an all-time high.
S&P Global puts short interest even higher, at 17.9%, up from 14.3% last week.
Blue Owl was also the most borrowed stock among all US equities on Wednesday, with over 19 million shares on loan.
All while financing rates to borrow the stock are up +266% MoM, signaling aggressive demand for shorts.
The private credit selloff is accelerating.
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Blue Owl Capital shares dropped -22.7% in February, posting their worst month on record.
This marks the 7th consecutive monthly decline, the longest streak in history.
Meanwhile, short interest in Blue Owl is up to 14.7%, an all-time high.
S&P Global puts short interest even higher, at 17.9%, up from 14.3% last week.
Blue Owl was also the most borrowed stock among all US equities on Wednesday, with over 19 million shares on loan.
All while financing rates to borrow the stock are up +266% MoM, signaling aggressive demand for shorts.
The private credit selloff is accelerating.
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A new shot literally regrows knee cartilage.
Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).
The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.
In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.
This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.
The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.
Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.
Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.
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Researchers at Stanford Medicine have identified a novel strategy to regenerate articular cartilage in knees and potentially prevent or treat osteoarthritis (OA).
The method targets 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an age-related enzyme—or "gerozyme"—that accumulates in aging tissues and drives degeneration.
In aged mice, small-molecule inhibitors of 15-PGDH, delivered systemically or via intra-articular injection, promoted cartilage thickening and regeneration of functional hyaline articular cartilage.
This occurred without recruiting stem or progenitor cells; instead, existing chondrocytes underwent transcriptional reprogramming to a youthful state, with reduced populations of inflammatory and hypertrophic/degradative cells and expanded matrix-producing articular chondrocytes.
The inhibitors also reversed natural age-related cartilage thinning, improved joint function, and—when administered after simulated ACL injuries—strongly mitigated post-traumatic OA progression and associated pain.
Human OA cartilage explants from total knee replacements responded similarly in vitro, showing decreased degradation markers and evidence of new articular cartilage formation.
Given that an oral 15-PGDH inhibitor has already completed Phase 1 safety trials for age-related muscle atrophy, the findings open a path toward disease-modifying, regenerative therapies that could delay or obviate the need for joint replacement surgery.
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Palantir founder Peter Thiel met with Japanese PM Sanae Takaichi to discuss “future prospects in the field of innovative technologies” in Japan and America
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BREAKING: Turkish Foreign Ministry:
We strongly condemn the UAV attacks carried out today in Azerbaijan’s Nakhchivan Autonomous Republic.
We once again emphasize that attacks targeting third countries in the region and increasing the risk of the war spreading must come to an end as soon as possible.
Türkiye will continue to stand by Azerbaijan, as it always has.
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We strongly condemn the UAV attacks carried out today in Azerbaijan’s Nakhchivan Autonomous Republic.
We once again emphasize that attacks targeting third countries in the region and increasing the risk of the war spreading must come to an end as soon as possible.
Türkiye will continue to stand by Azerbaijan, as it always has.
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R.I.P. Dubai
DUBAI IS URGING RESIDENTS TO TAKE SHELTER.
THE CITY IS UNDER HEAVY BOMBARDMENT.
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DUBAI IS URGING RESIDENTS TO TAKE SHELTER.
THE CITY IS UNDER HEAVY BOMBARDMENT.
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Omarchy Linux Rejects "Retarded" California Age Verification Law
DHH: "Omarchy has no plans to do anything in response to this retarded California law."
Plus: Fedora "not aware" of age verification laws, & Ubuntu is "reviewing it internally".
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DHH: "Omarchy has no plans to do anything in response to this retarded California law."
Plus: Fedora "not aware" of age verification laws, & Ubuntu is "reviewing it internally".
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Desperate Planned Parenthood now selling Botox, lip fillers and laughing gas to make cash after Trump slashed funding by $100M
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In Russia, former First Deputy Defense Minister Ruslan Tsalikov has been detained
Tsalikov has been charged with 12 counts of embezzlement and money laundering, as well as two counts of accepting bribes.
He faces up to 20 years in prison.
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Tsalikov has been charged with 12 counts of embezzlement and money laundering, as well as two counts of accepting bribes.
He faces up to 20 years in prison.
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Iran's National Security chief is threatening to kill and capture American ground troops.
"The valiant children of Imam Khomeini and Imam Khamenei are waiting for you to expose those corrupt American officials with a few thousand killed and captured.
The land of Iran is no place for the hellish dance of demons."
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"The valiant children of Imam Khomeini and Imam Khamenei are waiting for you to expose those corrupt American officials with a few thousand killed and captured.
The land of Iran is no place for the hellish dance of demons."
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FOLLOWUP (0.77, took 0.6s):
'Maybe Israel is trying to make some kind of complication between Iran and Turkey'
Iran's envoy to Indonesia, Mohammad Boroujerdi speaks to RT about alleged attacks in Turkey
'THEY want to escalate the problem for Iran with its neighbors'
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'Maybe Israel is trying to make some kind of complication between Iran and Turkey'
Iran's envoy to Indonesia, Mohammad Boroujerdi speaks to RT about alleged attacks in Turkey
'THEY want to escalate the problem for Iran with its neighbors'
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Iran's advanced missiles soar through the skies over the Israeli regime, showcasing their awe-inspiring maneuverability before obliterating terrorist targets
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The cost of shipping crude oil from the US to Asia is skyrocketing:
It now costs over $29 million to hire a supertanker to take 2 million barrels of crude from the US Gulf Coast to China, the highest on record.
Shipping rates have DOUBLED in just two weeks.
This means shipping alone costs ~$14.50 per barrel, or a record ~20% of the oil price at current WTI levels of ~$75.
The cost of a supertanker as a percentage of the WTI crude oil price has quadrupled since August, when it was ~5%.
This comes as the ongoing war in the Middle East has effectively shut down traffic through the Strait of Hormuz, forcing Asian buyers to turn to US barrels.
Many supertanker bookings to load crude from the US Gulf Coast have already been canceled over the last 24 hours as costs become unsustainable.
Oil supply chains are under historic stress.
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It now costs over $29 million to hire a supertanker to take 2 million barrels of crude from the US Gulf Coast to China, the highest on record.
Shipping rates have DOUBLED in just two weeks.
This means shipping alone costs ~$14.50 per barrel, or a record ~20% of the oil price at current WTI levels of ~$75.
The cost of a supertanker as a percentage of the WTI crude oil price has quadrupled since August, when it was ~5%.
This comes as the ongoing war in the Middle East has effectively shut down traffic through the Strait of Hormuz, forcing Asian buyers to turn to US barrels.
Many supertanker bookings to load crude from the US Gulf Coast have already been canceled over the last 24 hours as costs become unsustainable.
Oil supply chains are under historic stress.
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