Medical cannabis is widely used, but strong evidence supports only a few benefits.
In a comprehensive analysis of over 2,500 studies, UCLA Health researchers evaluated the scientific evidence behind medical cannabis. Their findings are straightforward: despite its surging popularity, cannabis has robust clinical backing for only a limited range of conditions.
Published in JAMA, the review spanned research from 2010 to 2025, incorporating randomized trials, meta-analyses, and clinical guidelines. Although many individuals use cannabis for chronic pain, anxiety, and insomnia, the supporting evidence for these applications is generally weak or conflicting. Over half of medical cannabis users cite chronic pain as their primary reason, but existing guidelines do not endorse it as a primary treatment option.
Strong evidence exists mainly for specific FDA-approved cannabinoid drugs, which effectively treat chemotherapy-induced nausea and vomiting, appetite loss in HIV/AIDS, and rare pediatric epilepsy syndromes like Dravet syndrome.
The study also drew attention to frequently downplayed risks. Prolonged use of high-THC cannabis, particularly among adolescents, is associated with elevated rates of psychotic symptoms and anxiety disorders. Roughly 29% of medical users develop cannabis use disorder. Frequent consumption has further been tied to heightened chances of heart attack, stroke, and coronary heart disease.
The researchers noted that widespread public support has far outstripped the available science. While cannabis can benefit certain patients in targeted scenarios, it is far from a universal remedy. They recommend that doctors assess patients for mental health and cardiovascular vulnerabilities and engage in candid, evidence-driven discussions.
The reality of cannabis in medicine is far more nuanced than common portrayals suggest. Clarifying its genuine benefits—and its limitations—is increasingly crucial.
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In a comprehensive analysis of over 2,500 studies, UCLA Health researchers evaluated the scientific evidence behind medical cannabis. Their findings are straightforward: despite its surging popularity, cannabis has robust clinical backing for only a limited range of conditions.
Published in JAMA, the review spanned research from 2010 to 2025, incorporating randomized trials, meta-analyses, and clinical guidelines. Although many individuals use cannabis for chronic pain, anxiety, and insomnia, the supporting evidence for these applications is generally weak or conflicting. Over half of medical cannabis users cite chronic pain as their primary reason, but existing guidelines do not endorse it as a primary treatment option.
Strong evidence exists mainly for specific FDA-approved cannabinoid drugs, which effectively treat chemotherapy-induced nausea and vomiting, appetite loss in HIV/AIDS, and rare pediatric epilepsy syndromes like Dravet syndrome.
The study also drew attention to frequently downplayed risks. Prolonged use of high-THC cannabis, particularly among adolescents, is associated with elevated rates of psychotic symptoms and anxiety disorders. Roughly 29% of medical users develop cannabis use disorder. Frequent consumption has further been tied to heightened chances of heart attack, stroke, and coronary heart disease.
The researchers noted that widespread public support has far outstripped the available science. While cannabis can benefit certain patients in targeted scenarios, it is far from a universal remedy. They recommend that doctors assess patients for mental health and cardiovascular vulnerabilities and engage in candid, evidence-driven discussions.
The reality of cannabis in medicine is far more nuanced than common portrayals suggest. Clarifying its genuine benefits—and its limitations—is increasingly crucial.
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NEW - Spanish police carry out a raid at the IRTA-CReSA state-funded laboratory near Barcelona, as part of an investigation into the origin of the recent African swine fever outbreak
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BREAKING: Photos from Epstein’s estate released by House Democrats — Bill Gates poses for a photograph with a woman whose face has been redacted
(Photo released by Democrats on the House Oversight Committee on Thursday, December 18.)
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(Photo released by Democrats on the House Oversight Committee on Thursday, December 18.)
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Crypto trading is experiencing a structural shift:
For years, serious liquidity lived off-chain on centralized exchanges, such as Coinbase and Binance.
Now, decentralized exchanges are becoming MORE efficient.
For example, a $1 million Solana, $SOL, trade on Solana decentralized exchanges (DEXs) now moves price just ~5 basis points, per JupiterExchange.
By comparison, Coinbase sees price swings of ~12 basis points, more than DOUBLE what Solana DEXs are seeing.
Institutional-grade execution is rapidly moving on-chain.
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For years, serious liquidity lived off-chain on centralized exchanges, such as Coinbase and Binance.
Now, decentralized exchanges are becoming MORE efficient.
For example, a $1 million Solana, $SOL, trade on Solana decentralized exchanges (DEXs) now moves price just ~5 basis points, per JupiterExchange.
By comparison, Coinbase sees price swings of ~12 basis points, more than DOUBLE what Solana DEXs are seeing.
Institutional-grade execution is rapidly moving on-chain.
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Outrage in Sweden after judge refuses to deport Mahmoud Shakir to Iraq for raping a 100-y-old woman while visiting her in her home as a caretaker
Judge Mohamed Ali says no to deportation because “Shakir is well-established in Sweden & has good contact with his Swedish daughter”
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Judge Mohamed Ali says no to deportation because “Shakir is well-established in Sweden & has good contact with his Swedish daughter”
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When my cousin who I told to go all in on crypto sees me across the table at Christmas dinner
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BREAKING: Bitcoin falls -$3,000 in 30 minutes as $140 million in levered long positions are liquidated in a matter of minutes.
Liquidations are back, again.
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Liquidations are back, again.
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JUST IN - White House announces that the Kennedy Center for the Performing Arts will "unanimously" be renamed to the Trump-Kennedy Center for the Performing Arts
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BBC: we are pushing misandrist narratives and persecuting boys in school while lying about the extent of misogny.
Commentary on LinkedIn:
It must be the dads.
Showing yet again, misandry is societal, systemic, normalised.
No evidence of misogny, just assumptions.
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Commentary on LinkedIn:
It must be the dads.
Showing yet again, misandry is societal, systemic, normalised.
No evidence of misogny, just assumptions.
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Harvard is investigating two students for their roles in drawing scrutiny to the relationship between former Harvard president Larry Summers and Jeffrey Epstein
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We are seeing MASSIVE swings in markets right now:
Between 11:55 AM ET and 12:25 PM ET, the S&P 500 erased -$450 billion in market cap.
23 minutes later and $320 billion in market cap has been added back.
That's a $720 BILLION swing in market cap in under 1 hour.
Capitalize on volatility.
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Between 11:55 AM ET and 12:25 PM ET, the S&P 500 erased -$450 billion in market cap.
23 minutes later and $320 billion in market cap has been added back.
That's a $720 BILLION swing in market cap in under 1 hour.
Capitalize on volatility.
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