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After Republicans called for the removal of migrants from dangerous countries, following an Afghan migrant shooting two soldiers, Democrats are replying that the group-oriented approach should be used to deport all White men
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BREAKING: BREAKING: Pastor John Amanchukwu called Candace Owens “evil” and “demonic”at an official TPUSA event while asking her husband to ask her to stop. Many conservatives are divided because they note ‘the pastor failed to call her a liar.’
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JUST IN - U.S. President Donald Trump on Venezuela: We’ll be starting to stop them on land soon
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.POTUS announces that U.S. Army Specialist Sarah Beckstrom of Summersville, West Virginia, one of the National Guardsmen savagely attacked yesterday in Washington, D.C., has just passed away.
May God be with her family
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May God be with her family
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“CAMBELLS SOUP EXECUTIVE”… caught on camera saying the “CHICKEN” is really from a “3-D PRINTER”!
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I don't think people understand how bad the Nucleus Genomics situation is. Unless the report Herasight published on them in July is completely made up, Nucleus has spent the past four years selling borderline fraudulent reports to thousands of customers.
When you're selling polygenic tests, whether for embryos or adults, the number one question is whether your genetic predictors work.
There's a straightforward way to test this: you run the predictor on a bunch of genomes you haven't seen before and check whether your predictions line up with reality. If you look at all the people who you said had a 50% risk of diabetes, did 50% of them have diabetes? If so, your model is well calibrated. If not, you've done something wrong.
If your predictors are slightly miscalibrated for one disease, that's not the end of the world. Maybe you didn't account for assortative mating properly or maybe you didn't have a large enough training set for people of subsaharan ancestry, or whatever. It's not great, but it's understandable.
But if you're miscalibrated on every disease, there's something fundamentally wrong with your approach.
So what happens when we assess Nucleus's calibration scores? What happens when we compare the risk they say people have with the risk they actually have?
The answer is they're systematically overconfident about almost every single disease their report covers. And half of the predictors basically don't work at all!
Every single one of those red bars should match the blue bar next ot them. The fact that all but one fail to do this indicates Nucleus has been systematically misleading its customers about their genetic risk.
This is not some small detail. Predicting genetic disease is Nucleus's core value proposition and they've spent almost their entire history lying about how well they can do it. They've sold thousands of these reports.
This doesn't happen by accident. The only way a company ends up with a report this misleading is by either being so incompetent that they don't even realize they're misleading people, or by lying on purpose to make their product look more informative than it is.
About five months ago, Nucleus hired Stephan Cordogan, a statistical geneticist, to work on making their predictors actually good. Stephan seems to have done what Nucleus should have done a long time ago: he trained actually good predictors and validated them against proper data sets like families in UK Biobank.
That's good. Unless they're misleading people again, they've got 9 properly validated disease predictors that actually work. But there are still two problems:
First, Nucleus is still offering a bunch of non-validated predictors in their embryo and adult reports. Maybe they magically validated all these without telling anyone, but if not, they are STILL misleading people.
Second, they have taken zero accountability for selling a borderline fraudulent report for the company's entire history.
It is simply not acceptable for a company to lie to every customer that walks in the door for four years, give them misleading medical information, and then expect they can sweep it under the rug. Especially when they are now entering a higher stakes field in which they'll be telling parents information that will be used to decide which embryo becomes their child!
This is textbook unethical business behavior and anyone financially supporting this sham should be publicly shamed for their lack of dilligence.
I don't understand how Silicon Valley VCs are this technically incompetent. Did anyone ask Nucleus why they hadn't published a single validation paper before investing in them? Do you guys all just outsource your thinking to the people who screen candidates for the Thiel Fellowship?
It is not enough for a founder to be a charismatic, or a good salesman. If you fund people who are willing to lie to get ahead, it will blow up in your face every time.
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When you're selling polygenic tests, whether for embryos or adults, the number one question is whether your genetic predictors work.
There's a straightforward way to test this: you run the predictor on a bunch of genomes you haven't seen before and check whether your predictions line up with reality. If you look at all the people who you said had a 50% risk of diabetes, did 50% of them have diabetes? If so, your model is well calibrated. If not, you've done something wrong.
If your predictors are slightly miscalibrated for one disease, that's not the end of the world. Maybe you didn't account for assortative mating properly or maybe you didn't have a large enough training set for people of subsaharan ancestry, or whatever. It's not great, but it's understandable.
But if you're miscalibrated on every disease, there's something fundamentally wrong with your approach.
So what happens when we assess Nucleus's calibration scores? What happens when we compare the risk they say people have with the risk they actually have?
The answer is they're systematically overconfident about almost every single disease their report covers. And half of the predictors basically don't work at all!
Every single one of those red bars should match the blue bar next ot them. The fact that all but one fail to do this indicates Nucleus has been systematically misleading its customers about their genetic risk.
This is not some small detail. Predicting genetic disease is Nucleus's core value proposition and they've spent almost their entire history lying about how well they can do it. They've sold thousands of these reports.
This doesn't happen by accident. The only way a company ends up with a report this misleading is by either being so incompetent that they don't even realize they're misleading people, or by lying on purpose to make their product look more informative than it is.
About five months ago, Nucleus hired Stephan Cordogan, a statistical geneticist, to work on making their predictors actually good. Stephan seems to have done what Nucleus should have done a long time ago: he trained actually good predictors and validated them against proper data sets like families in UK Biobank.
That's good. Unless they're misleading people again, they've got 9 properly validated disease predictors that actually work. But there are still two problems:
First, Nucleus is still offering a bunch of non-validated predictors in their embryo and adult reports. Maybe they magically validated all these without telling anyone, but if not, they are STILL misleading people.
Second, they have taken zero accountability for selling a borderline fraudulent report for the company's entire history.
It is simply not acceptable for a company to lie to every customer that walks in the door for four years, give them misleading medical information, and then expect they can sweep it under the rug. Especially when they are now entering a higher stakes field in which they'll be telling parents information that will be used to decide which embryo becomes their child!
This is textbook unethical business behavior and anyone financially supporting this sham should be publicly shamed for their lack of dilligence.
I don't understand how Silicon Valley VCs are this technically incompetent. Did anyone ask Nucleus why they hadn't published a single validation paper before investing in them? Do you guys all just outsource your thinking to the people who screen candidates for the Thiel Fellowship?
It is not enough for a founder to be a charismatic, or a good salesman. If you fund people who are willing to lie to get ahead, it will blow up in your face every time.
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TRUMP ADMIN TO SEEK DEATH PENALTY FOR AFGHAN SHOOTER, ORDERS REVIEW OF ALL GREEN CARDS FROM 19 COUNTRIES
The Trump administration announced it will seek the death penalty for Rahmanullah Lakanwal after National Guard member Sarah Beckstrom, 20, died from her injuries.
Trump:
"We have no greater national security priority than ensuring that we have full control over the people that enter and remain in our country.
For the most part, WE DON'T WANT THEM!"
USCIS Director Joe Edlow:
"At the direction of POTUS, I have directed a full scale, rigorous reexamination of every Green Card for every alien from every country of concern."
The 19 countries include Afghanistan, Iran, Haiti, Venezuela, Somalia, Cuba, Libya, Yemen, Sudan, and others.
DHS is also reviewing all asylum cases approved under the Biden administration.
A U.S. official told CNN the suspect was "clean on all checks" before coming to the U.S.
Clean on all checks.
A 20-year-old soldier is dead.
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The Trump administration announced it will seek the death penalty for Rahmanullah Lakanwal after National Guard member Sarah Beckstrom, 20, died from her injuries.
Trump:
"We have no greater national security priority than ensuring that we have full control over the people that enter and remain in our country.
For the most part, WE DON'T WANT THEM!"
USCIS Director Joe Edlow:
"At the direction of POTUS, I have directed a full scale, rigorous reexamination of every Green Card for every alien from every country of concern."
The 19 countries include Afghanistan, Iran, Haiti, Venezuela, Somalia, Cuba, Libya, Yemen, Sudan, and others.
DHS is also reviewing all asylum cases approved under the Biden administration.
A U.S. official told CNN the suspect was "clean on all checks" before coming to the U.S.
Clean on all checks.
A 20-year-old soldier is dead.
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DoomPosting
.POTUS announces that U.S. Army Specialist Sarah Beckstrom of Summersville, West Virginia, one of the National Guardsmen savagely attacked yesterday in Washington, D.C., has just passed away. May God be with her family 🄳🄾🄾🄼🄿🤖🅂🅃🄸🄽🄶
Sarah gave her life so that everyone else could spend time with their families.
Don't let Sarah's sacrifice be in vain
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Don't let Sarah's sacrifice be in vain
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Brooklyn mother says NYPD officers - including Sgt. Ardolino — used excessive force on her 15-year-old asthmatic son, leaving him injured and hospitalized.
She’s calling for accountability and for the public to share the incident. NYPD has not yet commented.
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She’s calling for accountability and for the public to share the incident. NYPD has not yet commented.
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