Yesterday, the International Scientific Conference on "New Materials and Helio-technologies" kicked off in the Institute of Material Sciences, Parkent region. The conference drew scientists from around the world, including South Korea, Switzerland, the US, Germany, China, Italy, France, Kazakhstan, Azerbaijan, Belarus, and Russia. Prof. Anvar Zakhidov delivered an amazing plenary talk on Carbon nanostructures and their applications, followed by insightful presentations from Prof. Gurdial Blugan and Dr. N. Sena Yüzbasi on Silicon oxycarbide-tin nanocomposites for high performance anode materials for Li-ion batteries and high-performance ceramics. We also discussed potential collaborations with Prof. Jingxiang Low on CO2 conversion. My student Davron Abduvokhidov presented his first talk on bio-nanosensors. Though Prof. Masaharu Shiratani couldn't attend the event, he did send a short video message. All in all, it was an enlightening conference.

[UZ] "Plazma qishloq xo'jaligi - kompyuter simulyatsiyasi yordamida fundamental tadqiqotlar" bo'yicha loyihamiz 2021 yilda muvaffaqiyatli moliyalashtirildi! 🎉

Loyihamizning rejasiga muvofiq, Materialshunoslik institutida modellashtirish guruhimizni tashkil qildik. Biz bu jamoani “Fanlararo kompyuter modellashtirish guruhi” deb nomlaganmiz. 💻🔬

Bizning guruhimiz hujayralardagi molekulyar darajadagi mexanizmlarni, masalan, membrana o'tkazuvchanligi, oqsil-oqsil bilan bog'lanish, oqsil-dori ta'siri va oqsil-DNK o'zaro ta'sirini o'rganishga bag'ishlangan. Bundan tashqari, biz molekulyar dinamika va zichlik funktsional nazariyasi kabi ilg'or usullardan foydalangan holda moddaning turli xossalarini, jumladan bionanosensorlar va fotokatalizatorlarni o'rganamiz.

Hamkorlik bizning tadqiqotimizning asosiy falsafasidir va biz turli fanlardan boshqa tadqiqotchilar, olimlar va muassasalar bilan hamkorlik qilshga tayyormiz. Birgalikda biz ilm-fanning sirli olamiga chuqurroq kirib borishimiz mumkin.

Agar siz biz bilan hamkorlik qilishni xohlasangiz yoki davom etayotgan tadqiqotlarimiz haqida ko'proq ma'lumot olishni istasangiz, biz bilan bog'laning. Keling, kuchlarni birlashtiraylik va tadqiqot darajasini oshiraylik!

[EN] Our project on "Plasma Agriculture - fundamental studies by computer simulations" was successfully funded in 2021! 🎉

In line with our project goals, we have established our modeling group at the Institute of Material Sciences. We have named this team the "Interdisciplinary Computer Modeling Group." 💻🔬

Our group is dedicated to unraveling the molecular-level mechanisms occurring within living cells, such as membrane permeability, protein-protein binding, protein-drug interactions, and protein-DNA interactions. In addition, we explore various aspects of material sciences, including bionanosensors and photocatalysts, using cutting-edge techniques such as molecular dynamics and density functional theory.

Collaboration is our main research philosophy, and we warmly welcome partnerships with fellow researchers, scientists, and institutions from diverse disciplines. Together, we can delve deeper into the fascinating world of science.

If you are interested in collaborating with us or would like to learn more about our ongoing research, please don't hesitate to reach out. Let's join forces and make the world of research better!

Dars 16: Mesitilen (1,3,5-trimetilbenzol - ham deb ataladi) bu gidrofob modda. Suv bilan fazaviy ajralishini modellashtirish yordamida tadqiq qilish. ATB (automatic topology builder - https://atb.uq.edu.au/) - MD uchun force field parametrlarni hosil qilib beradi. Serverdan foydalanish uchun ro'yxatdan o'tish kerak. ATB server bazasidagi hamma molekulalarni ta'sir potensiallarini tog'ridan to'g'ri olib foydalanib bo'lmaydi. Molekulalarni izlab topganizda Termodynamic Integration method bilan erkin energiyasini hisoblab qo'yganlari bor. Siz tajribada hisoblangan Gibbs energiyasi bilan solishtirib ko'rasiz, qay biriniki yaqin bo'lsa modellashtirish uchun aynan o'sha parametrlarni foydalanasiz. Shunda modellashtirish natijalari aniqroq chiqadi. Username: m.maxkamov@imssolar.uz; Password: Sho2hdDS

[EN] Today, I had the opportunity to give a talk at the Institute of the Chemistry of Plant Substances on "The Power of Computer Simulations to Understand the Molecular Level Mechanisms that Occur at the Cellular Level" and it was amazing! I'm thrilled to have received such a positive response from the audience, including researchers expressing their interest and asking many questions. After the talk, we discussed possible future collaboration with the lab members of Azimova Shaxnoz Sadikovna, who have extracted various compounds and tested them for cell viability. Some of the compounds showed promising results against cancer cell lines, but we still have a lot of work to do to reveal the exact mechanisms behind this. Hopefully, our collaboration will be fruitful!
#Science #CancerResearch #Collaboration

[UZ] 🔬🖥 Kompyuter simulyatsiyalari yordamida hayot sirlarini o'rganish! 🔬🖥
Kompyuter simulyatsiyalari bizning hujayralarimizda sodir bo'ladigan murakkab biofizik va biokimyoviy jarayonlar haqidagi tushunchamizda inqilob qilganini bilasizmi? 🧬
Ilmiy tadqiqotlarning maftunkor dunyosida kompyuter modellashtirish hayot sirlarini ochishda hal qiluvchi rol o'ynaydi. 🌱 Keling, kompyuter simulyatsiyalari nima uchun bunchalik muhimligini va ular bizga nima uchun kerakligini ko'rib chiqamiz:
1️⃣ Murakkab tizimlarni tushunarliroq qildi: Hujayraning ichki ishi juda murakkab yo'llar bilan o'zaro ta'sir qiluvchi son-sanoqsiz molekulalarni o'z ichiga oladi. Kompyuter modellashtirish orqali olimlar molekulalarning qanday harakatlanishi, bog'lanishi va o'zgarishi haqida vizual va miqdoriy tushunchani ta'minlab, ushbu o'zaro ta'sirlarni simulyatsiya qilishlari mumkin. Bu molekulyar darajadagi hayotning yashirin dinamikasini ochib beradigan virtual mikroskopga o'xshaydi!
2️⃣ Ko'rinmaydigan narsalarni o'rganish: Hujayra ichida sodir bo'ladigan ko'plab jarayonlarni eksperimental kuzatish qiyin. Kompyuter simulyatsiyalari bizga bu erishib bo'lmaydigan olamlarni ko'rib chiqishga imkon beradi, bu esa oqsillarning konformatsiyasi, DNK replikatsiyasi va ferment katalizi kabi hodisalar haqida tushuncha beradi. Ushbu jarayonlarni vizualizatsiya qilish orqali biz topilmalarimizni tasdiqlash uchun muhim mexanizmlarni va dizayn tajribalarini ochishimiz mumkin.
3️⃣ Dorilarni dizaynlashda yo'l ko'rsatish: Kompyuter simulyatsiyalari yangi dori vositalarini yaratishda muhim rol o'ynaydi. Virtual skrining va molekulyar dokingi orqali olimlar potentsial dori molekulalari tanadagi aniq maqsadlar bilan qanday o'zaro ta'sir qilishini taxmin qilishlari mumkin. Bu istiqbolli nomzodlarni samarali aniqlash, dori vositalarini topish jarayonida vaqt va resurslarni tejash imkonini beradi.
4️⃣ Biologik muhandislikni optimallashtirish: Kompyuter modellari ishlab chiqilgan biologik tizimlarni loyihalash va optimallashtirishda yordam beradi. Metabolik yo'llardan to sintetik gen ketma-ketligiga qadar simulyatsiyalar ushbu murakkab tizimlarning xatti-harakatlarini bashorat qilishi mumkin, bu esa yanada samarali va ishonchli bioinjeneriya mahsulotlarini ishlab chiqishga yordam beradi.
5️⃣ Tajribalar va nazariyalarni birlashtirish: Kompyuter simulyatsiyalari eksperimental ma'lumotlar va nazariy asoslar o'rtasida ko'prik bo'lib xizmat qiladi. Eksperimental natijalarni hisoblash modellariga integratsiyalashgan holda, olimlar o'z nazariyalarini takomillashtirishlari va eksperimental ravishda sinovdan o'tkazilishi mumkin bo'lgan bashoratlarini amalga oshirishlari mumkin. Bu sinergiya ilmiy taraqqiyotni tezlashtiradi va hayot haqidagi tushunchamizni kengaytiradi.
Xulosa qilib aytganda, kompyuter simulyatsiyasi hujayralarning iishlashi haqida bilim olishga intilishda ajralmas vositaga aylandi. Ular bizga ko'rinmas narsalarni o'rganishga, murakkab narsalarni tadqiq qilishga va yangi kashfiyotlar uchun yo'l ochishga imkon beradi.
Shunday qilib, keling, kompyuter modellashtirishning kuchini va uning hayotning murakkabliklarini tushunishni rivojlantirishga qo'shgan ajoyib hissasini olqishlaylik! 🌟
[EN] 🔬🖥 Exploring the Secrets of Life with Computer Simulations! 🔬🖥
Did you know that computer simulations have revolutionized our understanding of the intricate biophysical and biochemical processes that occur within our cells? 🧬
In the fascinating world of scientific research, computer modeling plays a crucial role in unraveling the mysteries of life. 🌱 Let's delve into why computer simulations are so important and why we need them:
1️⃣ Complex Systems Made Understandable: The inner workings of a cell involve countless molecules interacting in highly complex ways. Through computer modeling, scientists can simulate these interactions, providing a visual and quantitative understanding of how molecules move, bind, and transform. It's like a virtual microscope revealing the hidden dynamics of life at the molecular level!

2️⃣ Exploring the Unseen: Many processes occurring inside a cell are challenging to observe experimentally. Computer simulations allow us to peek into these inaccessible realms, providing insights into phenomena such as protein folding, DNA replication, and enzyme catalysis. By visualizing these processes, we can uncover essential mechanisms and design experiments to validate our findings.
3️⃣ Guiding Drug Discovery: Computer simulations play a vital role in the development of new drugs. Through virtual screening and molecular docking, scientists can predict how potential drug molecules interact with specific targets in the body. This enables efficient identification of promising candidates, saving time and resources in the drug discovery process.
4️⃣ Optimizing Biological Engineering: Computer models aid in the design and optimization of engineered biological systems. From metabolic pathways to synthetic gene circuits, simulations can predict the behavior of these complex systems, guiding the construction of more efficient and reliable bioengineered products.
5️⃣ Bridging Experiments and Theory: Computer simulations serve as a bridge between experimental data and theoretical frameworks. By integrating experimental results into computational models, scientists can refine their theories and make predictions that can be tested experimentally. This synergy accelerates scientific progress and expands our understanding of life.
In a nutshell, computer simulations have become indispensable tools in the pursuit of knowledge about the inner workings of cells. They allow us to explore the invisible, decipher the intricate, and pave the way for groundbreaking discoveries.
So, let's appreciate the power of computer modeling and its incredible contributions to advancing our understanding of life's complex tapestry! 🌟
#SimulationScience #ComputationalBiology #UnravelingLife #ScientificInquiry

Genomic Innovation in Rice: Transforming Black, Brown, and Red Varieties With CRISPR
https://scitechdaily.com/genomic-innovation-in-rice-transforming-black-brown-and-red-varieties-with-crispr/