We propose that MT plus-end-associated centralspindlin recruits a cortical pool of Dm ECT2 upon physical contact to activate RhoA
https://elifesciences.org/articles/38968
https://elifesciences.org/articles/38968
eLife
Microtubule plus-ends act as physical signaling hubs to activate RhoA during cytokinesis
MT plus-end-mediated recruitment of a cortical pool of ECT2 trigger RhoA activation upon contact, which results in localized contractility during cytokinesis.
elective disruption of microtubule organization revealed that both astral and central spindle microtubules can recruit RhoA at the equatorial cortex.
https://pubmed.ncbi.nlm.nih.gov/16352658/
https://pubmed.ncbi.nlm.nih.gov/16352658/
PubMed
Centralspindlin regulates ECT2 and RhoA accumulation at the equatorial cortex during cytokinesis - PubMed
During determination of the cell division plane, an actomyosin contractile ring is induced at the equatorial cell cortex by signals from the mitotic apparatus and contracts to cause cleavage furrow progression. Although the small GTPase RhoA is known to regulate…
It can be used to simulate forces that can be exerted at a cellular or a subcellular level
what we can have is filments and associated molecules, like molecular motors or cross linkers that interact with these filaments and exert forces even at a nanometer scale and we can see how these forces propagate over tens of micrometers
it simulates filaments based on connected segments, and you have some associated molecules which can interact with these cytoskeletal elements.
https://www.embl.org/training/self-paced-learning/simulating-cytoskeleton-cytosim/#:~:text=Cytosim%20is%20an%20accessible%20simulation,up%20to%20a%20few%20cells.
what we can have is filments and associated molecules, like molecular motors or cross linkers that interact with these filaments and exert forces even at a nanometer scale and we can see how these forces propagate over tens of micrometers
it simulates filaments based on connected segments, and you have some associated molecules which can interact with these cytoskeletal elements.
https://www.embl.org/training/self-paced-learning/simulating-cytoskeleton-cytosim/#:~:text=Cytosim%20is%20an%20accessible%20simulation,up%20to%20a%20few%20cells.
www.embl.org
Simulating the Cytoskeleton Using Cytosim
Cytosim is an accessible simulation software – developed by EMBL scientists – to simulate realistic individual elements of the cytoskeletal network.
To position the division plane, the microtubule-rich mitotic spindle communicates with the cell cortex via Rho GTPase-mediated signal transduction pathways to locally activate the assembly and constriction of the actomyosin contractile ring at the cell equator
水水的摸鱼日常
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245201/#R19
Active myosin-II binds to diaphanous-related formin-generated actin filaments and drives constriction of these filaments, much like the sliding filament model defining the contraction of muscle cells.
a calcium ionophore can induce calcium oscillation in oocytes and initiate the fertilization process.
Forwarded from 每个女孩都是最美的女孩
赶在今天结束的尾巴发了proposal（
其实按计划应该需要再通读（改）一遍但真的literally从早改到晚看了一天脑子已经一个字都不能过了
只能说，可能还是有写遣词造句不太满意，但整个逻辑链应该在我力所能及的范围给改到了我能认可的程度。
希望不是一个过几年回头看会觉得丢脸的文章（笑（指的就是你！我申请时写的PS/RS!
除开proposal之外，做了几次（分别是对lab和对同事）pratice talk，很多地方也都还没满意，也收到了很多非常非常有价值的建议，至少大概知道了改的方向。明天下午约了人继续practice talk，希望talk也能被完善到一个可以让我就算面对非常mean的committee member（呜呜说的就是某老板）也能很自信的讲出来的程度（当然如果被问到了确实没预料到的问题就再说吧（望天
其实按计划应该需要再通读（改）一遍但真的literally从早改到晚看了一天脑子已经一个字都不能过了
只能说，可能还是有写遣词造句不太满意，但整个逻辑链应该在我力所能及的范围给改到了我能认可的程度。
希望不是一个过几年回头看会觉得丢脸的文章（笑（指的就是你！我申请时写的PS/RS!
除开proposal之外，做了几次（分别是对lab和对同事）pratice talk，很多地方也都还没满意，也收到了很多非常非常有价值的建议，至少大概知道了改的方向。明天下午约了人继续practice talk，希望talk也能被完善到一个可以让我就算面对非常mean的committee member（呜呜说的就是某老板）也能很自信的讲出来的程度（当然如果被问到了确实没预料到的问题就再说吧（望天
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