老板：Because you have expressed interest in learning practical problem, , I am considering a mini exercise project that will probably take you a week or two to complete.
我真是能给自己找事情干啊TAT
我真是能给自己找事情干啊TAT
Supervised classification: trained with dataset with feature value and known classification - to partition the feature space in a way that separate the known classes
vs.
Unsupervised classification: trained with dataset with feature value but without know classification - find partition that result in district clusters of data points
vs.
Unsupervised classification: trained with dataset with feature value but without know classification - find partition that result in district clusters of data points
Mahalanobis distance:
1. find multivariate outliers
2. compare two dataset's similarity
https://www.youtube.com/watch?v=spNpfmWZBmg
1. find multivariate outliers
2. compare two dataset's similarity
https://www.youtube.com/watch?v=spNpfmWZBmg
YouTube
23: Mahalanobis distance
Multivariate distance with the Mahalanobis distance. Using eigenvectors and eigenvalues of a matrix to rescale variables.
你校我问到的别的美本，不管是东北的东南的中部的，手里都握着UMN的offer-bio/chem/neuroscience（但都没去），我怀疑UMN就是贵校的终极备胎
使用时空可控的光交联配体小分子探针特异性地靶向DNA G4（一种特殊的四链 DNA二级结构）并且不干扰G4-蛋白相互作用
https://mp.weixin.qq.com/s/ND0j34jwYNeSy7cR28z6yA
https://mp.weixin.qq.com/s/ND0j34jwYNeSy7cR28z6yA
https://mp.weixin.qq.com/s/-uxDWR14PPAp9AeGZDTctA
碱基编辑器的两大类是胞嘧啶碱基编辑器 (CBE)，将 C•G 转换为 T•A，以及腺嘌呤碱基编辑器 (ABE)，将 A•T 转换为 G•C。CBE 和 ABE 可以高效率和产品纯度（所有编辑的等位基因中仅包含所需编辑的部分）安装转换突变，但通常无法有效安装转换突变，包括 C•G 到 G•C。
碱基编辑器的两大类是胞嘧啶碱基编辑器 (CBE)，将 C•G 转换为 T•A，以及腺嘌呤碱基编辑器 (ABE)，将 A•T 转换为 G•C。CBE 和 ABE 可以高效率和产品纯度（所有编辑的等位基因中仅包含所需编辑的部分）安装转换突变，但通常无法有效安装转换突变，包括 C•G 到 G•C。
Image registration: is the process of transforming different sets of data into one coordinate system
https://en.wikipedia.org/wiki/Expansion_microscopy#cite_note-:0-2
Expansion microscopy (ExM) is a sample preparation tool for biological samples that allows investigators to identify small structures by expanding them using a polymer system. The premise is to introduce a polymer network into cellular or tissue samples, and then physically expand that polymer network using chemical reactions to increase the size of the biological structures. Current research allows for the expansion of samples up to 16x larger than their initial size. This technique has been found useful in various laboratory settings, such as analyzing biological molecules. ExM allows researchers to use standard equipment in identifying small structures, but requires following of procedures in order to ensure clear results.
卧槽还有这种有意思的玩意儿
Expansion microscopy (ExM) is a sample preparation tool for biological samples that allows investigators to identify small structures by expanding them using a polymer system. The premise is to introduce a polymer network into cellular or tissue samples, and then physically expand that polymer network using chemical reactions to increase the size of the biological structures. Current research allows for the expansion of samples up to 16x larger than their initial size. This technique has been found useful in various laboratory settings, such as analyzing biological molecules. ExM allows researchers to use standard equipment in identifying small structures, but requires following of procedures in order to ensure clear results.
卧槽还有这种有意思的玩意儿
Wikipedia
Expansion microscopy
utilizing polymers to examine small biological samples
pronucleus: the haploid nucleus of either the egg or sperm, both present in the fertilized egg prior to their fusion
During mitosis, there are five stages of cell division: Prophase, Prometaphase, Metaphase, Anaphase, and Telophase
原来现在细胞分裂已经是五个阶段了吗
原来现在细胞分裂已经是五个阶段了吗