🇨🇦 MCCQE1,2 | #Case_193 | #answer
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✅ C

🔎 Explanation

Asymptomatic persons between 50 and 80 years of age should be screened for colon cancer. A single fecal occult blood test (FOBT) performed in the office after a digital rectal examination is an inadequate screen, with significant false negative and false-positive rates. Annual six-sample FOBT (two samples from three different bowel movements) improves colon cancer detection but can still have false-negative results. If any of the six samples tests positive for occult blood, colonoscopy is recommended

🇨🇦 MCCQE1,2 | #Case_194
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Five days ago you prescribed amoxicillin for 10 days, to a 34-year-old female with purulent nasal drainage and tenderness over her maxillary sinuses. She returns today with worsening symptoms. Which one of the following would be the best choice for continued therapy?

a) Change to a high-dose amoxicillin regimen
b) Complete the prescribed regimen of amoxicillin
c) Discontinue amoxicillin and initiate antihistamines
d) Discontinue amoxicillin and start azithromycin
e) Discontinue amoxicillin and start levofloxacin

🇨🇦 MCCQE1,2 | #Case_194 | #answer
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✅ E

🔎 Explanation

First-line therapy consists of amoxicillin. A macrolide or trimethoprim-sulfamethoxazole combination should be used for patients with beta-lactam allergy. Second-line agents include amoxicillin-clavulanic acid combinations or fluoroquinolones (choice E) with enhanced Gram-positive activity. Failure of response after 72 hours of antibiotic treatment indicates antibiotic resistance and the antibiotic should be changed to another class or a second-line agent. When antibiotics are used, a 10-day course is considered sufficient.

⚠ While high-dose amoxicillin (choice A) is recommended as a first-line therapy, it is not recommended for treatment failures.

⚠ An alternative treatment strategy is indicated for patients who fail to show some response to empiric antimicrobial therapy after three to five days (choice B).

⚠ Given the symptoms of an infectious etiology, antihistamines (choice C) alone are not appropriate.

⚠ Azithromycin (choice D) should be used for patients with beta-lactam allergy

🇨🇦 MCCQE1,2 | #Case_195
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A 36-year-old woman comes to her gynecologist because of a three-month history of amenorrhea. Until this time, her menstrual periods had been regular. She also complains of decreased sex drive, worsening over the past couple of months. The patient denies any other symptoms. She has no significant medical history, although she started seeing a psychiatrist five months ago after a brief hospitalization during which she was diagnosed with major depressive disorder, severe, with psychotic features. Her depressive symptoms are resolving. Which of the following medications is most likely responsible for the patient's presenting complaints during her visit to her gynecologist?

a) Fluoxetine
b) Quetiapine
c) Risperidone
d) Trazodone
e) Venlafaxine

🇨🇦 MCCQE1,2 | #Case_195 | #answer
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✅ C

🔎 Explanation

Risperidone is an atypical antipsychotic agent. Conventional antipsychotics are clearly associated with elevations in plasma prolactin concentrations due to blockade in the tuberoinfundibular dopaminergic pathway. Dopamine binds to pituitary lactotrophs to inhibit the release of prolactin. Conventional antipsychotics block dopamine receptors, which releases this inhibition. The newer atypical antipsychotics have minimal, if any effect on plasma prolactin concentrations, except for risperidone, which is associated with elevated prolactin. Antipsychotic-induced hyperprolactinemia may cause side effects including amenorrhea and infertility, sexual dysfunction, galactorrhea, and weight gain. Given this patient's non-contributory medical history and lack of other symptoms, the onset of her complaints correlates with the initiation of treatment for psychotic depression. A morning plasma prolactin level should be obtained.

⚠ Fluoxetine (choice A) is a selective serotonin reuptake inhibitor (SSRI). It does not cause significant elevations in serum prolactin. Although SSRIs are commonly associated with sexual side effects, including diminished libido, but especially delayed orgasm, they are not associated with amenorrhea.

⚠ Quetiapine (choice B) is an atypical antipsychotic agent that is not associated with significant or persistent elevations in plasma prolactin concentrations, unlike risperidone.

⚠ Trazodone (choice D) is an older antidepressant agent that is commonly used for insomnia associated with
depression. Although it may cause sexual side effects, it does not interfere with menstruation.

⚠ Venlafaxine (choice E) is a serotonin and norepinephrine reuptake inhibitor that may cause sexual side effects, but does not cause amenorrhea

🇨🇦 MCCQE1,2 | #Case_196
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A 5-year-old boy develops the acute onset of testicular pain. There is no fever or history of trauma. You are considering both testicular torsion and orchitis. Which of the following is false?

a) The pain of orchitis is relieved by gently elevating the testicle
b) Orchitis is more common in childhood than torsion
c) Irreversible damage may occur as a result of testicular torsion
d) When orchitis is diagnosed in prepubertal males, antibiotics are most commonly unnecessary
e) The incidence of orchitis has diminished since the introduction of the measles/mumps/rubella (MMR) vaccine

🇨🇦 MCCQE1,2 | #Case_196 | #answer
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✅ B

🔎 Explanation

Torsion is much more common than orchitis in childhood and this should be kept in mind when considering the diagnosis of testicular pain.

⚠A. Elevation of the testicle results in pain relief in epididymitis and orchids but not improve torsional pain

⚠C. Only a few hours remain for intervention before irreversible damage occurs.

⚠D. In this patient orchitis is most likely caused by viral infections, which would not respond to antibiotic treatment.(In mumps orchitis, 4 out of 5 cases occur in prepubertal males (younger than 10 years). In bacterial orchitis, most cases are associated with epididymitis (epididymo-orchitis), and they occur in sexually active males older than 15 years or in men older than 50 years with benign prostatic hypertrophy)

⚠E. As mumps is a primary cause of orchitis, the widespread use of this vaccine has decreased the number of cases of orchitis.

🇨🇦 MCCQE1,2 | #Case_197
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For several years, a hypertensive 65-year-old female has been treated with hydrochlorothiazide, 25 mg/day; atenolol (Tenormin), 100 mg/day; and hydralazine (Apresoline), 50 mg 4 times/day. Her blood pressure has been well controlled on this regimen. Over the past 2 months she has experienced malaise, along with diffuse joint pains that involve symmetric sites in the fingers, hands, elbows, and knees. A pleural friction rub is noted on examination. Laboratory testing shows that the patient has mild anemia and leucopenia, with a negative rheumatoid factor and a positive antinuclear antibody (ANA) titer of 1:640. Which one of the following would be the most appropriate initial treatment?

a) Discontinue the thiazide diuretic and switch to a loop diuretic such as furosemide (Lasix)
b) Discontinue the hydralazine
c) Begin treatment with prednisone, 40 mg/day orally
d) Treat with hydroxychloroquine (Plaquenil), 400 mg/day
e) Obtain renal function studies and anticipate that a renal biopsy will be needed

🇨🇦 MCCQE1,2 | #Case_197 | #answer
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✅ B

🔎 Explanation

There are many drugs that can induce a syndrome resembling systemic lupus erythematosus, but the most common offender is procainamide, followed by hydralazine. There is a genetic predisposition for this drug-induced lupus, determined by drug acetylation rates. Polyarthritis and pleuropericarditis occur in half of patients, but fortunately, CNS and renal involvement are rare. While all patients with this condition have positive ANAs and most have antibodies to histones, antibodies to double-stranded DNA and decreased complement levels are rare, which distinguishes drug-induced lupus from idiopathic lupus. The best initial management is to withdraw the drug, and most patients improve in a few weeks. For those with severe
symptoms, a short course of corticosteroids is indicated. Once the offending drug is discontinued, symptoms seldom last beyond 6 months.

🇨🇦 MCCQE1,2 | #Case_198
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A 60-year-old male indicates that he occasionally brings up what appears to be undigested food long after his meal. He also admits that he sometimes chokes on food, and that his wife says he has bad breath. The most likely diagnosis is:

a) Achalasia
b) Esophageal reflux
c) Cancer of esophagus
d) Zenker’s diverticulum
e) Large cervical bone spur

🇨🇦 MCCQE1,2 | #Case_198 | #answer
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✅ D

🔎 Explanation

The combination of halitosis, late regurgitation of undigested food, and choking suggests Zenker’s diverticulum. Patients may also have dysphagia and weight loss. The diagnosis is usually made with a barium swallow. The treatment is surgical

🇨🇦 MCCQE1,2 | #Case_199
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A 39-year-old automobile mechanic presents because of the new onset of wheezing. His medications are propranolol, enalapril, hydrochlorothiazide, ranitidine and occasional pseudoephedrine for symptoms of allergic rhinitis. On physical examination, he appears comfortable. His blood pressure is 134/88 mm Hg, pulse is 68/min, and respirations are 18/min. On lung examination, soft expiratory wheezes are heard throughout both lung fields. Which of the following medications is most likely contributing to his wheezing?

a) Enalapril
b) Hydrochlorothiazide
c) Propranolol
d) Pseudoephedrine
e) Ranitidine

🇨🇦 MCCQE1,2 | #Case_199 | #answer
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✅ C

🔎 Explanation

Propranolol, like other nonspecific beta blockers, may cause bronchospasm by blocking the beta receptors in the bronchial tree. Beta stimulation in the lungs produces bronchodilation, and its blockade leads to bronchoconstriction. In fact, propranolol is contraindicated in patients with known asthma or chronic obstructive pulmonary disease (COPD)

🇨🇦 MCCQE1,2 | #Case_200
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A 39-year-old man is brought to the emergency department by his same sex partner because of confusion, diplopia and mild right arm weakness. On examination the patient is somewhat agitated and shows confusion for recent events. There is decreased pupillary response on the left with some paresis of lateral gaze on the right. Temperature is 38.3°C (101.0°F). Peripheral leukocyte count is increased.
The most appropriate next step in evaluation of his neurologic signs and symptoms is:

a) Bilateral carotid arteriography
b) CT scan of the head
c) Electroencephalography
d) Lumbar puncture
e) Serum test for HIV antibodies

🇨🇦 MCCQE1,2 | #Case_200 | #answer
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✅ B

🔎 Explanation

The patient is described as a homosexual male with both subacute and acute neurologic abnormalities. Furthermore, the neurologic signs and symptoms described clearly indicate focal findings as would be seen with a mass lesion. In a homosexual man, one would suspect the possibility of toxoplasmosis, and a CT scan of the head should be performed. Toxoplasmosis would be revealed as multiple ring-enhancing lesions.

⚠ Bilateral carotid angiography and an electroencephalogram are not indicated at this time.

⚠ A lumbar puncture would in fact be contraindicated given the possibility of a mass lesion and possible increased intracranial pressure.

⚠ While order a serum test for HIV antibodies may be appropriate it will not be most useful in evaluating his current signs and symptoms

🇨🇦 MCCQE1,2 | #Case_201
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An 80-year-old male presents with the chief complain of a “bone spur”, describing mid-heel pain that worsens as the day progresses. The pain is not relieved with ibuprofen. Examination reveals tenderness in the central aspect of the heel and a radiograph of the foot is unremarkable. The most likely diagnosis is:

a) Multiple myeloma
b) Fat-pad atrophy
c) Tarsal tunnel syndrome
d) S1 radiculopathy
e) Plantar fasciitis

🇨🇦 MCCQE1,2 | #Case_201 | #answer
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✅ B

🔎 Explanation

Fat-pad atrophy is a common cause of heel pain in the geriatric patient, and in contrast to plantar fasciitis, causes pain as the day progresses.

⚠ Plantar fasciitis classically presents as morning pain.

⚠ Tarsal tunnel syndrome causes neuropathic pain in the distribution of the posterior tibial nerve, radiating into the plantar aspect of the foot toward the toes.

⚠ Lumbar radiculopathy involves pain radiating down the leg into the heel, and is usually associated with weakness of dorsiflexion of the big toe and a decreased ankle reflex.

⚠ Multiple myeloma would be an extremely unusual cause of heel pain; heel pain associated with cancer more commonly presents nocturnally

🇨🇦 MCCQE1,2 | #Case_202
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A 32-year-old female presents with bilateral pretibial tender, mildly red nodules 2 - 4 cm in diameter. A nodule that appeared earlier resolved, leaving a “bruised” area. She had a similar problem once when she was pregnant but it resolved spontaneously. Her medications include lovastatin (Mevacor) for hyperlipidemia and a low-dose oral contraceptive prescribed 5 months earlier. Her past history and a review of systems are otherwise unremarkable. The most appropriate next step would be to:

a) Order a serum creatinine phosphokinase level
b) Obtain a cervical culture for gonorrhea
c) Discontinue her oral contraceptives
d) Discontinue lovastatin
e) Treat with glucocorticoids

🇨🇦 MCCQE1,2 | #Case_202 | #answer
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✅ C

🔎 Explanation

Erythema nodosum (EN) is a panniculitis most often appearing on the shins. In 35% - 55% of cases, no cause is found. EN has been associated with pregnancy and oral contraceptives (choice C). Other drugs including sulfonamides, bromides, iodides, and omeprazole have been associated with EN. Statins have not been associated with EN. Infectious agents associated with EN include beta-hemolytic streptococci, Mycobacterium, Yersinia, fungi, syphilis, Campylobacter, hepatitis C, and Epstein-Barr virus. Inflammatory conditions associated with EN include inflammatory bowel disease, sarcoidosis, Lofgren’s syndrome and Behçet’s syndrome. EN is usually self-limited or resolves with treatment of the underlying disorder. Glucocorticoids are usually not necessary for idiopathic EN.

🇨🇦 MCCQE1,2 | #Case_203
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A 67-year-old female presents to your department with her husband and they report that she has been experiencing mood swings with unusually frequent irritability, decreased sleep need, racing thoughts, and excitation. The patient has a 4-year history of rheumatoid arthritis and was recently started on a new medication. Which of the following is the most likely medication the patient is being treated with?

a) Gold salts
b) Methotrexate
c) Meloxicam
d) Prednisone
e) Minocycline

🇨🇦 MCCQE1,2 | #Case_203 | #answer
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✅ D

🔎 Explanation

This patient presents with psychiatric symptoms suggestive of a mania. Moods swings, irritability, decreased need to sleep, racing thoughts, excitation, and other symptoms usually associated with bipolar disorder are seen in many patients treated with prednisone (choice D) or other corticosteroids, especially with doses higher than 40 mg per day. Psychiatric side effects associated with corticosteroids are reversible with discontinuation of the drug or significant reduction in dose. Other common side effects of corticosteroids to be aware of are hypertension, hirsutism, obesity, diabetes mellitus, peptic ulcer disease, fatty liver, leukocytosis, oral candidiasis, myopathy, osteoporosis, and cataracts.

⚠ Gold salts (choice A) can cause coloring of the skin in shades of mauve to a purplish dark grey when exposed to
sunlight, if the salts are taken on a regular basis over a long period of time. They can also cause kidney damage, pruritus, and oral ulcers.

⚠ Methotrexate (choice B) can cause ulcerative stomatitis, leukopenia with immunosuppression, pneumonitis, pulmonary fibrosis, dizziness, and kidney failure.

⚠ Meloxicam (choice C) like most NSAIDs can cause peptic ulcers, tinnitus, and skin rash. However, compared to other NSAIDs its side effects profile is favourable.

⚠ Minocycline (choice E) can cause diarrhea, photosensitivity, dizziness, lupus, blue-gray skin, and like other tetracyclines it can cause discoloration of teeth, especially in children.

🔖 Key point:

High dose corticosteroids can cause psychiatric adverse effects, particularly mood changes, which are reversible with discontinuation of the drug or significant reduction in dose