Forwarded from Rasheed Al_Shalabi
10 causes of autoimmune :-
😞( 3 decrease)
- ⬇ -ve selection decrease Tcell education
- ⬇ T cell reg (Foxp3)
- ⬇ Fasl and Fas suppress apoptosis
😞( 3 increase)
- ⬆ TH17 leads to SLE , Asthma , RF ,MS
- ⬆ sequestered Ag (by trauma)
- ⬆ estrogen enhance B cell activaion , suppress T cell regu
😞( 3 alteration لخبطيشن )
- alteration of auto-antegen by drug as pencillin
-cross reaction as RF
- polyclonal activation of B cell (as EBV infection)
😞( the last one )
- genetic
3+3+3+1🙄 10
😞( 3 decrease)
- ⬇ -ve selection decrease Tcell education
- ⬇ T cell reg (Foxp3)
- ⬇ Fasl and Fas suppress apoptosis
😞( 3 increase)
- ⬆ TH17 leads to SLE , Asthma , RF ,MS
- ⬆ sequestered Ag (by trauma)
- ⬆ estrogen enhance B cell activaion , suppress T cell regu
😞( 3 alteration لخبطيشن )
- alteration of auto-antegen by drug as pencillin
-cross reaction as RF
- polyclonal activation of B cell (as EBV infection)
😞( the last one )
- genetic
3+3+3+1🙄 10