نجي الان لل
2]medium size vasculitis:-
-the both are histologically the same:- ايش نشوف في السلايد
Necrotizing vasculitis or fibrionid necrosis or both
🔸necrotizing > means pus (agreggate of neutrophils)
🔸fibrinoid necrosis> amorphus - structurless fibrin mass

# Clinically:-
1]PAN:-
-يصيب اي عمر ولكن ليس الاطفال.
-multi systemic disease affect all organs :- kidney -GIT - skin ... except lung.
- there is heamaturia - proteinurea -GIT bleeding -skin rash & lymphadenopathy.

2]Kawasaki:-
-affect neonate .
-Mucocutaneous lymph node syndrome:-
1)mucocutaneous rash.
2)lymphadenopathy.
3)fever.

🔴 في الشرائح لا نستطيع التفريق بين النوعين الا clinically
Child >> kawasaki
30 years >> PAN

🔹Disease:-
polyarteritis nodosa or Kwasaki.

🔹features:-
-general features of vasculitis observed
-necrotizing vasculitis and fibrinoid necrosis.

🔹Disease:-
polyarteritis nodosa or kawasaki

🔹features:-
appears of general features of vasculitis
fibrinoid necrosis (واضحه اكثر)
and necrotizing vasculitis

نجي الان لاخر جزء في ال vasculitis 🤓
3) small size vasculitis:-
هنا العكس
They are the same at clinical features but they are different histologically "-"
هنا نتوقع بيكون معانا
more systemic disease even the lung is effected

1] wegener's granulomatosis:-
نستطيع تمييزها ب:-
necrotizing granuloma
يعني في
granuloma(epitheloid cells)
وفي وسطها
neutrophil infiltration (pus)

We can't see the blood vessel wall.

-it affect upper and lower RT, kidney.
-the arteioles - capillaries and the surrounding C.T. are also affected.

🔴 necrosis is occur>> perforation of nasal septum - perforation of septum between oral and nasal cavities

2] microscobic polyangitis:-
يشبه ال PAN الذي يصيب ال medium size
-we can see necrotizing vasculitis or fibrinoid necrosis (but rare)

*specific feature:-
Leukocyto clastic fragmentation vasculitis
وهذه العلامه ما تظهر الا في هذا النوع وتعني انه احنا بنشوف مثلا النيتروفل مقسمه مثلا lobe مع شوية cytoplasm وكذا يعني fragments 😐

3] churg streuss syndrome:-
Specific feature:- esinophilia
سواء كان داخل ال tissue
Or at the blood

🔹Disease:-
Wegener's disease

🔹features:-
we can't see the blood vessel wall (there's distruction of the wall and invasion to the surrounding tissue)

*specific feature:-
necrotizing granuloma ( epitheloid cells and neutrophil at the middle)

🔹Disease:-
Wegener's disease

🔹features:-
necrotizing granuloma ( neutropil at the middle)

🔴 الفرق بين الصورتين
انه في الصورة الاولى كانت بداية اكون ال granuloma
اما الثانيه قد تكونت ال granuloam وال neutrophil فيها اكثر

🔹Disease:-
microscopic polyangitis

🔹features:-
leukocyto clastic fragmentation vasculitis( we can see the fragmented leukocyte)

🔹Disease:-
Microscopic polyangitis

🔹features:-
leukocyto clastic fragmentation vascullitis ( infiltrated by fragmented neutrophil)

بعد ما خلصنا من موضوع ال vasculitis
ذكر الدكتور بعض الامراض نذكر بعض الملاحظات عليها 😊😊
Specific vascular disease
مثل:-
🔹Aneurysm:-
Abnormal permanent segmental dilatation of the arterial wall.
-Causes:-
1)Congenital :- Berry aneurysm
2) acquired :- infection - trauma
-it's asymptomatic.
-if rupture lead to death

🔹Arteiolo sclerosis= hypertention
فيها نوعين :-
*Hyaline (amorphous mass):- caused by benign hypertention.
*Hyperplastic (onion shaped):- caused by malignant hypertention.

🔹Raynaud's disease:-
-mechanism :- sever vaso spasm >> vasoconistriction
- it called Raynaiud's phenomen if there is underling cause like SLE.

🔹Atherosclerosis :-
Atheroma:- mass compsed of fat (cholesterol) , fibrin , leukocyte , smooth muscle
Fibrous cap:- it's stablish the atheroma by smooth muscle which migrate to intima

🔹Angiosarcoma
Malignant tumer of blood vessel we see anaplastic change of the endothelial cells with infiltration of the endothelial cells.
كما سنرى في السلايد

🔴 لم نذكر الامراض بالتفصيل سيطول شرحها 😊😊
المعذرة ع اي خطأ غير مقصود والعفو منكم
خلود الفاقوس 😊

🔹Disease:-
Abdominal aortic aneurysm

🔹feature:-
Abnormal permanent segmental dilatation of blood vessels

🔹Disease:-
Arterolosclerosis (Hypertention)

🔹features:-
hyperplastic arteriolosclerosis (Onion shaped)

🔹Disease:-
Arteriolosclerosis (Hepertention)

🔹featuers:-
Hyaline arteriolosclerosis
(Amorphous material)

🔹Disease:-
Raynaud's disease / phenomen

🔹fearures:-
-blue discoloration
-cyanosis

🔹Disease:-
Atherosclerosis

🔹featuers:-
Atheroma composed of :- fibrous cap , fibrin , leukocyte , smooth muscle - fat (cholesterol all are found in intima)

🔹Disease:-
Atherosclerosis

🔹featuers:-
Atheroma composed of :- fibrous cap , fibrin , leukocyte ,foamy cells smooth muscle - fat (cholesterol all are found in intima)

🔹Disease:-
Atherosclerosis

🔹featuers:-
-thickened intima
-Atheroma composed of :- fibrous cap , fibrin , leukocyte , smooth muscle - foamy cells , fat (cholesterol cleft)
-thrombus as a complication

Gross picture of Atherosclerosis show mass in the lumen

Gross picture of Angiosarcoma

🔹bruise-like lesion that grows over time on skin

🔹Disease:-
Angiosarcoma

🔹features:-
-endothelial cells show anaplastic changes of malignancy
-infiltration of the endothelial cells

🔹Disease:-
Angiosarcoma

🔹features:-
-the endothelial cells show anaplastic changes of malignancy.
-with high mitotic division