For the first time in more than 2.5 years, OpenAI models took a larger share of OpenRouter user spending than Anthropic models last week.

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🔥 An AI that helps you actually solve what's going on in your life

Most tools in this space are the same base model with a system prompt on top, nothing wrong with that, just worth being upfront about it.

iXo is built the same way, on leading frontier models, with one deliberate design choice: instead of one-shot prompting, it runs a structured, ongoing intake across separate life domains, work, finances, health, relationships, building a persistent context model, then reasoning across that instead of a single prompt window.

Practical effect: it surfaces the actual cause behind a problem, not just a plausible-sounding answer, a symptom in one area (say, focus at work) traced back to its real cause in another (say, sleep). No diagnosis, no decisions made for you, it surfaces the connection, you decide what to do with it.

📌 It's live now as a web app, nothing to install, just a tab. Access is limited while it rolls out, with a mobile app and a couple of connected devices said to be next.

TRY NOW

❗️6 OpenAI employees left in 2021 to build Anthropic. 5 years later, six of them just debuted on the Forbes 400 with an estimated net worth of $15.5 billion each.

Daniela Amodei, Dario Amodei, Tom Brown, Jack Clark, Jared Kaplan and Sam McCandlish are now worth $93B combined.

Forbes estimates each owns around 1.6% of Anthropic, which was valued at $965 billion in May.

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🗣 Satya Nadella talks about how in Quincy, Washington, a 400/500 MW data center has contributed to a rural town over many years.

The tax revenues have gone up 12X, continued economic growth, new infrastructure, and public infra such as a school, hospital, town center, and aquatic center.

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💊 Insilico wants to build “longevity vaccines” with AI

Insilico Medicine has launched a new research initiative aimed at using AI and programmable RNA to target some of the earliest cellular drivers of aging.

Instead of treating diseases after damage has accumulated, the company wants to use a single, self-limiting treatment to help the body’s own immune system identify and eliminate problematic cells.

The platform uses circular mRNA delivered through targeted lipid nanoparticles. The genetic instructions would temporarily equip a patient’s own T cells to recognize and clear specific cell populations, including senescent cells, fibrotic cells and autoreactive immune cells.

Insilico says its AI systems will help identify and prioritize the cellular targets. The first focus is immune-system rejuvenation by removing senescent lymphocytes, with metabolic dysfunction and other age-related conditions also being explored.

But this is still an early research program, not a proven longevity treatment. Insilico has not yet disclosed program-specific safety or efficacy data or a clinical trial timeline.

Source.

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🗣 Anthropic CEO Dario Amodei:

“Even if we froze the [AI] technology in place, which we’re not doing, we’re making use of maybe only 5% or 10% of its possible value.”

“The technology will keep getting better.”

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As recently as Dec 2024, the typical AI researcher thought AI wouldn't solve a Millennium math problem until 2054.

Source.

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Private AI community ❗️

We are gathering founders, researchers, investors and others working in AI for discussions & networking with like-minded people.

👽 Want to join? Send a short intro about yourself to @rational.

We’ll invite those who are genuinely a strong fit

❗️Google deepmind opened the deepmind institute.

The consequences of AGI are being examined, for even by Google DeepMind standards, we are close to AGI.

Source.

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Just a quick reminder: This is the definition of AGI by Google Deepmind’s definition.

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