Forwarded from W_INTEL WIRE (Tier1 OSINT Feed)
Ivermectin Inhibiting Colorectal Cancer.pdf
3 MB
Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth
Cell cycle progression is one of the critical signaling mechanisms of homeostasis maintenance in healthy tissues and normal cells. Induction of cell arrest in cancer cells is a valuable strategy for anticancer drug development. Several studies support that ivermectin leads to cell cycle arrest phase in some cancer cells. In addition, ivermectin could also cause cholangiocarcinoma cell arrest at the S phase. The present study demonstrated that ivermectin induced S-phase arrest in SW480 and SW1116 cells.
In conclusion, we have demonstrated that ivermectin may regulate the expression of crucial molecules in the apoptosis pathway by increasing ROS production and inhibiting the cell cycle in the S phase to inhibit colorectal cancer cells. Therefore, current results indicate that ivermectin might be a new potential anticancer drug for treating human colorectal cancer and other cancers.
@wokeinteldrops
@EXOINTEL
Cell cycle progression is one of the critical signaling mechanisms of homeostasis maintenance in healthy tissues and normal cells. Induction of cell arrest in cancer cells is a valuable strategy for anticancer drug development. Several studies support that ivermectin leads to cell cycle arrest phase in some cancer cells. In addition, ivermectin could also cause cholangiocarcinoma cell arrest at the S phase. The present study demonstrated that ivermectin induced S-phase arrest in SW480 and SW1116 cells.
In conclusion, we have demonstrated that ivermectin may regulate the expression of crucial molecules in the apoptosis pathway by increasing ROS production and inhibiting the cell cycle in the S phase to inhibit colorectal cancer cells. Therefore, current results indicate that ivermectin might be a new potential anticancer drug for treating human colorectal cancer and other cancers.
@wokeinteldrops
@EXOINTEL
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Global science must stand up for Iran’s imprisoned scholars
Iranian researchers are at risk as never before. Governments are urging quiet diplomacy. But a new book shows why public campaigns matter.
The importance of publicity is an overriding message. Moore-Gilbert’s family in Australia was advised by its government not to go public about her case, because this could complicate negotiations for her release. But those who avoid publicity become a lower priority for their governments. Moore-Gilbert recalls a phone call with her father in which he said the government was advising staying quiet. In response, she said, “Dad, listen to me — I don’t have much time. You need to go to the media. Tell them what’s happening to me. Tell them I’ve been arrested and that I’m being kept in solitary and denied visits from the embassy.”
https://www.nature.com/articles/d41586-022-00995-7
Iranian researchers are at risk as never before. Governments are urging quiet diplomacy. But a new book shows why public campaigns matter.
The importance of publicity is an overriding message. Moore-Gilbert’s family in Australia was advised by its government not to go public about her case, because this could complicate negotiations for her release. But those who avoid publicity become a lower priority for their governments. Moore-Gilbert recalls a phone call with her father in which he said the government was advising staying quiet. In response, she said, “Dad, listen to me — I don’t have much time. You need to go to the media. Tell them what’s happening to me. Tell them I’ve been arrested and that I’m being kept in solitary and denied visits from the embassy.”
https://www.nature.com/articles/d41586-022-00995-7
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Particle’s surprise mass threatens to upend the standard model
Data from an old experiment find that the mass of the W boson is higher than theory predicts, hinting at future breakthroughs.
The measurement “is extremely exciting and a truly monumental result in our field”, says Florencia Canelli, an experimental particle physicist at the University of Zurich in Switzerland. If it is confirmed by other experiments, it could be the first major breach in the standard model of particle physics, a theory that has been spectacularly successful since it was introduced in the 1970s. The standard model is known to be incomplete, however, and any hint of how it might fail could point the way to its replacement, and to the existence of new elementary particles. “We believe there is a strong clue in this particular measurement about what nature might have in store for us,” says Ashutosh Kotwal, an experimental particle physicist at Duke University in Durham
https://www.nature.com/articles/d41586-022-01014-5
Data from an old experiment find that the mass of the W boson is higher than theory predicts, hinting at future breakthroughs.
The measurement “is extremely exciting and a truly monumental result in our field”, says Florencia Canelli, an experimental particle physicist at the University of Zurich in Switzerland. If it is confirmed by other experiments, it could be the first major breach in the standard model of particle physics, a theory that has been spectacularly successful since it was introduced in the 1970s. The standard model is known to be incomplete, however, and any hint of how it might fail could point the way to its replacement, and to the existence of new elementary particles. “We believe there is a strong clue in this particular measurement about what nature might have in store for us,” says Ashutosh Kotwal, an experimental particle physicist at Duke University in Durham
https://www.nature.com/articles/d41586-022-01014-5
Contractor who accused Karnataka Minister of corruption ends life in Udupi
A few weeks ago, Mr. Patil had written to Prime Minister Narendra Modi claiming to have invested ₹4 crore on building roads in his village based on oral instructions of Mr. Eshwarappa. He accused the Minister of lies, corruption and irregularities, and urged Mr. Modi to direct Mr. Eshwarappa to settle his bills.
Mr. Patil, national secretary of Hindu Yuva Vahini, had told The Hindu that he had to offer ₹15 lakh in bribes in the Rural Development Department to get payment for his bills.
https://www.thehindu.com/news/national/karnataka/contractor-who-accused-kse-of-corruption-is-missing/article65313670.ece
A few weeks ago, Mr. Patil had written to Prime Minister Narendra Modi claiming to have invested ₹4 crore on building roads in his village based on oral instructions of Mr. Eshwarappa. He accused the Minister of lies, corruption and irregularities, and urged Mr. Modi to direct Mr. Eshwarappa to settle his bills.
Mr. Patil, national secretary of Hindu Yuva Vahini, had told The Hindu that he had to offer ₹15 lakh in bribes in the Rural Development Department to get payment for his bills.
https://www.thehindu.com/news/national/karnataka/contractor-who-accused-kse-of-corruption-is-missing/article65313670.ece
Russian buildup in eastern Ukraine seen in satellite photos
Russia invaded Ukraine on Feb. 24, drawing condemnation from the United States and many other countries around the world. The Russian offensive was initially spread widely, with forces advancing on the Ukrainian capital Kyiv in the north, cities such as Mariupol in the south and the Donbas and other regions in the east.
Things have changed in the past week or so, however; Ukrainian fighters have pushed Russian forces out of Kyiv and other northern areas, and the invaders have deployed more troops and military hardware to the south and, especially, the east.
https://www.space.com/russian-buildup-eastern-ukraine-satellite-photos
Russia invaded Ukraine on Feb. 24, drawing condemnation from the United States and many other countries around the world. The Russian offensive was initially spread widely, with forces advancing on the Ukrainian capital Kyiv in the north, cities such as Mariupol in the south and the Donbas and other regions in the east.
Things have changed in the past week or so, however; Ukrainian fighters have pushed Russian forces out of Kyiv and other northern areas, and the invaders have deployed more troops and military hardware to the south and, especially, the east.
https://www.space.com/russian-buildup-eastern-ukraine-satellite-photos
WSA Enlil model runs suggest that a CME (associated with a C1 flare at 11/0521 UTC from now plage Region 2987) will likely impact Earth on 14 Apr. A G2 (Moderate) Geomagnetic Storm Watch has been issued for 14 Apr 2022, and a G1 (Minor) Geomagnetic Storm Watch has been issued for 15 Apr 2022 as CME effects persist into the 15th. Visit https://swpc.noaa.gov for continuing updates and forecasts.
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Forwarded from Ice Age Farmer
China's corn planting facing delays as lockdowns leave farmers stuck in cities
Planting of corn in one of China’s major producing areas could be delayed as many of the region’s millions of farmers struggle to return home from temporary city jobs because of strict coronavirus lockdowns.
Any delay to planting could hit output in the world’s No. 2 corn producer, where corn prices are already hovering at record levels, and government support for soybeans also threatens to reduce growing of the grain.
China’s northeastern provinces, its bread basket, have endured weeks of restrictions on movement, with the toughest measures in Jilin province where COVID-19 cases soared in early March.
With the critical time for sowing grain fast approaching, some farmers remain stuck and are getting increasingly worried, despite recent government pledges to tackle the issue.
“I need to tend my land immediately, but I can’t go back. I am so anxious,” a farmer surnamed Wang told Reuters on Tuesday from Changchun, the capital of Jilin.
The problem highlights the challenge for China in balancing its strict zero-COVID policy with its high priority on food security.
Fertiliser supplies to the region have also been disrupted by the transport curbs, and farmers are already facing record prices of the crop nutrient as well as diesel and other costs.
#china #corn
https://www.reuters.com/article/health-coronavirus-china-farming-idINL3N2WA256
Planting of corn in one of China’s major producing areas could be delayed as many of the region’s millions of farmers struggle to return home from temporary city jobs because of strict coronavirus lockdowns.
Any delay to planting could hit output in the world’s No. 2 corn producer, where corn prices are already hovering at record levels, and government support for soybeans also threatens to reduce growing of the grain.
China’s northeastern provinces, its bread basket, have endured weeks of restrictions on movement, with the toughest measures in Jilin province where COVID-19 cases soared in early March.
With the critical time for sowing grain fast approaching, some farmers remain stuck and are getting increasingly worried, despite recent government pledges to tackle the issue.
“I need to tend my land immediately, but I can’t go back. I am so anxious,” a farmer surnamed Wang told Reuters on Tuesday from Changchun, the capital of Jilin.
The problem highlights the challenge for China in balancing its strict zero-COVID policy with its high priority on food security.
Fertiliser supplies to the region have also been disrupted by the transport curbs, and farmers are already facing record prices of the crop nutrient as well as diesel and other costs.
#china #corn
https://www.reuters.com/article/health-coronavirus-china-farming-idINL3N2WA256
Reuters
China's corn planting facing delays as lockdowns leave farmers stranded
Planting of corn in one of China's major producing areas could be delayed as many of the region's millions of farmers struggle to return home from temporary city jobs because of strict coronavirus lockdowns.
Forwarded from Ice Age Farmer
U.S. Treasury Secretary Janet Yellen will convene a meeting of top international financial officials next week to address a global food-security crisis, with the heads of institutions including the IMF urging action to address dire consequences of record price surges caused by Russia’s invasion of Ukraine.
But they won’t tel you to grow a garden. They won’t hand out seeds - which are cheaper than C19 test kits. What a farce.
https://www.bloomberg.com/news/articles/2022-04-13/yellen-to-convene-global-food-crisis-gathering-as-costs-surge
But they won’t tel you to grow a garden. They won’t hand out seeds - which are cheaper than C19 test kits. What a farce.
https://www.bloomberg.com/news/articles/2022-04-13/yellen-to-convene-global-food-crisis-gathering-as-costs-surge
Bloomberg.com
Yellen Plans Global Food-Crisis Summit as IMF, UN Urge Action
U.S. Treasury Secretary Janet Yellen will convene a meeting of top international financial officials next week to address a global food-security crisis, with the heads of institutions including the IMF urging action to address dire consequences of record…
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Forwarded from MoD Russia
🗓 Top News Today
▫️ 1,026 Ukrainian servicemen of the 36th Marine Brigade have voluntarily laid down their arms and surrendered as a result of a successful offensive by the Russian Armed Forces and Donetsk People's Republic militia units. Among them, the Ukrainian Armed Forces have surrendered 162 officers, as well as 47 servicewomen.
❗️ The Russian Defence Ministry sees attempts of sabotage and strikes by Ukrainian forces against facilities on Russian Federation territory. If such cases continue, the Russian Armed Forces will strike at decision-making centres, including in Kiev, from which the Russian army has so far refrained.
▫️ A commercial seaport in Mariupol city has been completely liberated from Nazi Azov fighters. All hostages held by the Nazis on the ships in the port, including foreigners, have been released. The remnants of the Ukrainian and Azov Nazi units in the city have been blockaded and deprived of the opportunity to break out of their encirclement.
📹 The Russian Defence Ministry has published footage of army aviation crews destroying Ukrainian air defence positions and armoured vehicles and destroying a battery of 152 mm D-20 howitzers of the Ukrainian armed forces. Video of Russian military engineers securing spring sowing operations in Kharkov Region has also been published.
❗️ Neo-Nazis blocked more than 450 civilians, including children, women with babies, the elderly and seriously ill people connected to life-support machines, cancer patients and insulin-dependent people, in Nikolo-Vasilevskoe monastery in Volnovakha district of the Donetsk People's Republic.
#MoD #Russia #Ukraine
@mod_russia_en
▫️ 1,026 Ukrainian servicemen of the 36th Marine Brigade have voluntarily laid down their arms and surrendered as a result of a successful offensive by the Russian Armed Forces and Donetsk People's Republic militia units. Among them, the Ukrainian Armed Forces have surrendered 162 officers, as well as 47 servicewomen.
❗️ The Russian Defence Ministry sees attempts of sabotage and strikes by Ukrainian forces against facilities on Russian Federation territory. If such cases continue, the Russian Armed Forces will strike at decision-making centres, including in Kiev, from which the Russian army has so far refrained.
▫️ A commercial seaport in Mariupol city has been completely liberated from Nazi Azov fighters. All hostages held by the Nazis on the ships in the port, including foreigners, have been released. The remnants of the Ukrainian and Azov Nazi units in the city have been blockaded and deprived of the opportunity to break out of their encirclement.
📹 The Russian Defence Ministry has published footage of army aviation crews destroying Ukrainian air defence positions and armoured vehicles and destroying a battery of 152 mm D-20 howitzers of the Ukrainian armed forces. Video of Russian military engineers securing spring sowing operations in Kharkov Region has also been published.
❗️ Neo-Nazis blocked more than 450 civilians, including children, women with babies, the elderly and seriously ill people connected to life-support machines, cancer patients and insulin-dependent people, in Nikolo-Vasilevskoe monastery in Volnovakha district of the Donetsk People's Republic.
#MoD #Russia #Ukraine
@mod_russia_en
