🔆#معلومة

✅Benefit from adding GP IIb/IIIa inhibitors to aspirin therapy is greatest among those with highest-risk features (those with elevated biomarkers,
those with diabetes, those undergoing revascularization) and in those not receiving adequate pretreatment with P2Y12 inhibitor.




🟡 Reference: #ACCP

🟡#PharmaDr_Khalid
🟡@WikipharmaDr 🟡

Choosing the antihypertensive drugs based on specific comorbidities , age , sex, race

🅾️ملاحظة بخصوص ال
GP IIb/IIIa inhibitors

✅the smaller-molecule agents eptifibatide and tirofiban depend on renal clearance;
✔️adjustment of the infusion is recommended to decrease the risk of bleeding;
✔️monitor SCr (CrCl).

✅ All GP IIb/IIIa inhibitors can cause thrombocytopenia;
✔️monitor hemoglobin (Hgb),hematocrit (Hct), and Plt.
✔️When administered with UFH, rates of thrombocytopenia
with either tirofiban or eptifibatide are no greater than with UFH alone.


🟡 Reference: #ACCP

🟡#PharmaDr_Khalid
🟡@WikipharmaDr 🟡

🅾️الجرع التي تستخدم في ال ACS

✅Eptifibatide
(Integrilin)
📌PCI: 180 mcg/kg IVB × 2 (10 min apart); 2 mcg/kg/min initiated after first bolus for 18–24 hrc;

📌ACS without PCI: Of uncertain benefit in patients adequately
pretreated with a P2Y12 receptor inhibitor; bolus used as above..

♨️If CrCl < 50 mL/min,
reduce infusion by 50%;
avoid in patients on
hemodialysis; not studied in patients with SCr > 4 mg/

✅Tirofiban
(Aggrastat)
✔️PCI: 25 mcg/kg IVB over 3 min; then 0.15 mcg/kg/min for 18 hr

♨️If CrCl ≤ 60 mL/min,
reduce infusion by 50%


🟡 Reference: #ACCP

🟡#PharmaDr_Khalid
🟡@WikipharmaDr 🟡

⭕️ما هي الأدويةالتي نختارها ك first choice أو ك خطوة أولى في علاج ال ADHF يترافق معه إرتفاع في الضغط
hypertension crisis
وإيضا Acute MI ❓

✅نبدأ بواحد من ال
loop diuretics

✅ثم الnitroglycerin
the drug of choice
for patients with ADHF and active ischemia
✅ ال (nitroprusside)
can also be used as an alternative to
inotropes in patients with elevated systemic vascular resistance (SVR) and low CO.


🟡#ACPP_2021
🟡#PharmaDr_Khalid
🟡@WikipharmaDr 🟡

📮Patients are our partners in health care, and our efforts may be for naught without their informed participation in the process.
🙂🙂

⭕️معالجة ال Constipation عند المرأة الحامل :
✅Cause: Decreased peristalsis
✅Nonmedical treatment ➡️Increase high-fiber foods.
➡️Increase fluid intake to eight 8-oz glasses of water a day.
➡️ Increase exercise.
✅ Symptomatic relief
➡️ Stool softeners (check that prenatal vitamin does not already contain docusate)
➡️ Bulk laxatives: Not absorbed.
➡️Stimulants: Not recommended as first-line therapy.
➡️Avoid mineral oil: Impairs vitamin K absorption and could cause hypoprothrombinemia.

🔖#ACCP_2022
🟡#PharmaDr_Khalid
🟡@WikipharmaDr 🟡

⭕️ عند معالجة ال TB يجب أن نعلم عندما يكون هناك
( drug resistance )
لدواء ال isoniazid
نستخدم هذه الأدوية للمعالجة:
✅rifampin, pyrazinamide, ethambutol, and moxifloxacin or levofloxacin)
لمدة شهرين ثم نكمل لمدة سبعة أشهر بال :
✅rifampin (or rifabutin) plus ethambutol plus
moxifloxacin (or levofloxacin) ..


أما عندما تكون المقاومة لدواء ال (rifampin )

يجب أن نستخدم هذه الأدوية :
✅isoniazid, pyrazinamide, and ethambutol
لمدة (9–12 )شهر
أو بإمكاننا إضافة ال (streptomycin) لأول شهرين من أجل نقصرة فترة المعالجة لتسعة أشهر فقط ..


🔰#ACCP2022

🟡#PharmaDr_Khalid
🟡@WikipharmaDr 🟡

⭕️Ferric citrate is FDA approved as a phosphate binder and may be useful for oral iron supplementation in patients with CKD